CRBS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRBS_HUMAN
• UniProt AC: P22914
• Protein Name: Beta-crystallin S
• Gene Name: CRYGS
• Organism: Homo sapiens (Human).
• Sequence Length: 178
• Protein Description: Crystallins are the dominant structural components of the vertebrate eye lens..
• Protein Sequence: MSKTGTKITFYEDKNFQGRRYDCDCDCADFHTYLSRCNSIKVEGGTWAVYERPNFAGYMYILPQGEYPEYQRWMGLNDRLSSCRAVHLPSGGQYKIQIFEKGDFSGQMYETTEDCPSIMEQFHMREIHSCKVLEGVWIFYELPNYRGRQYLLDKKEYRKPIDWGAASPAVQSFRRIVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Glutathionylation	FQGRRYDCDCDCADF CCCCEEECCCCHHHH	4.09	22833525
25	Glutathionylation	GRRYDCDCDCADFHT CCEEECCCCHHHHHH	6.10	22833525
27	Glutathionylation	RYDCDCDCADFHTYL EEECCCCHHHHHHHH	5.00	22833525
83	Glutathionylation	LNDRLSSCRAVHLPS CCHHHHCCEEEECCC	2.66	22833525

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRBS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRBS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRBS_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CRBS_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 116100: Cataract 20, multiple types (CTRCT20)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Methylation

"Shotgun identification of protein modifications from proteincomplexes and lens tissue.";
MacCoss M.J., McDonald W.H., Saraf A., Sadygov R., Clark J.M.,Tasto J.J., Gould K.L., Wolters D., Washburn M., Weiss A., Clark J.I.,Yates J.R. III;
Proc. Natl. Acad. Sci. U.S.A. 99:7900-7905(2002).
Cited for: METHYLATION [LARGE SCALE ANALYSIS] AT LYS-7, SUSCEPTIBILITY TOOXIDATION, AND MASS SPECTROMETRY.
PubMed: 12060738