CYLC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CYLC2_HUMAN
• UniProt AC: Q14093
• Protein Name: Cylicin-2
• Gene Name: CYLC2
• Organism: Homo sapiens (Human).
• Sequence Length: 348
• Subcellular Localization: Cytoplasm, cytoskeleton, perinuclear theca, calyx. Sperm head cytoskeletal structure.
• Protein Description: Possible architectural role during spermatogenesis. May be involved in spermatid differentiation..
• Protein Sequence: MSLPRFQRVNFGPYDNYIPVSELSKKSWNQQHFALLFPKPQRPGTKRRSKPSQIRDNTVSIIDEEQLRGDRRQPLWMYRSLMRISERPSVYLAARRQPLKPTRTVEVDSKAAEIGKKGEDKTTQKDTTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKDSATESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEKESADSKKDAKKNAKKDAKKDAKKNAKKDEKKDAKKKGK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
49	Phosphorylation	RPGTKRRSKPSQIRD CCCCCCCCCCHHHCC	53.61	23532336
58	Phosphorylation	PSQIRDNTVSIIDEE CHHHCCCEEEECCHH	21.66	26434776
60	Phosphorylation	QIRDNTVSIIDEEQL HHCCCEEEECCHHHH	16.28	26434776
78	Phosphorylation	RRQPLWMYRSLMRIS CCCCHHHHHHHHHHH	5.86	24043423
80	Phosphorylation	QPLWMYRSLMRISER CCHHHHHHHHHHHCC	14.72	24043423
85	Phosphorylation	YRSLMRISERPSVYL HHHHHHHHCCCCHHH	19.72	24043423
87	Methylation	SLMRISERPSVYLAA HHHHHHCCCCHHHHH	23.23	-
89	Phosphorylation	MRISERPSVYLAARR HHHHCCCCHHHHHCC	29.61	29083192
91	Phosphorylation	ISERPSVYLAARRQP HHCCCCHHHHHCCCC	8.58	29083192
95	Methylation	PSVYLAARRQPLKPT CCHHHHHCCCCCCCC	31.96	-
96	Methylation	SVYLAARRQPLKPTR CHHHHHCCCCCCCCC	37.43	-
104	Phosphorylation	QPLKPTRTVEVDSKA CCCCCCCEEEECHHH	24.40	-
122	Phosphorylation	GKKGEDKTTQKDTTD HCCCCCCCCCCCCCC	46.94	30622161
123	Phosphorylation	KKGEDKTTQKDTTDS CCCCCCCCCCCCCCC	39.09	30622161
127	Phosphorylation	DKTTQKDTTDSESEL CCCCCCCCCCCHHHH	39.27	30622161
128	Phosphorylation	KTTQKDTTDSESELK CCCCCCCCCCHHHHH	47.89	30622161
130	Phosphorylation	TQKDTTDSESELKQG CCCCCCCCHHHHHHC	40.71	30622161
132	Phosphorylation	KDTTDSESELKQGKK CCCCCCHHHHHHCCC	52.78	30622161
139	Acetylation	SELKQGKKDSKKGKD HHHHHCCCCCCCCCC	74.24	18527827
143	Acetylation	QGKKDSKKGKDIEKG HCCCCCCCCCCHHHH	75.13	18527833
145	Acetylation	KKDSKKGKDIEKGKE CCCCCCCCCHHHHHH	65.50	18527839
172	Acetylation	KKDAEKGKDSATESE HHHHHCCCCCCCCCC	60.62	19809713
174	Phosphorylation	DAEKGKDSATESEDE HHHCCCCCCCCCCCC	40.34	30622161
176	Phosphorylation	EKGKDSATESEDEKG HCCCCCCCCCCCCCC	43.95	30622161
178	Phosphorylation	GKDSATESEDEKGGA CCCCCCCCCCCCCCC	46.09	30622161
182	Acetylation	ATESEDEKGGAKKDN CCCCCCCCCCCCCCC	74.99	19809719
186	Acetylation	EDEKGGAKKDNKKDK CCCCCCCCCCCCCCC	65.03	19809725
196	Phosphorylation	NKKDKKDSNKGKDSA CCCCCCCCCCCCCCC	49.69	-
202	Phosphorylation	DSNKGKDSATESEGE CCCCCCCCCCCCCCC	40.34	26074081
204	Phosphorylation	NKGKDSATESEGEKG CCCCCCCCCCCCCCC	43.95	26074081
206	Phosphorylation	GKDSATESEGEKGGT CCCCCCCCCCCCCCC	46.69	26074081
213	Phosphorylation	SEGEKGGTEKDSKKG CCCCCCCCHHCCCCC	48.83	-
230	Phosphorylation	DSKKGKDSAIELQAV CCCCCCCCHHHHHEE	34.33	27251275
278	Phosphorylation	KKDKKKPSSTDSDSK CCCCCCCCCCCCCCH	55.54	30576142
279	Phosphorylation	KDKKKPSSTDSDSKD CCCCCCCCCCCCCHH	44.77	30576142
280	Phosphorylation	DKKKPSSTDSDSKDD CCCCCCCCCCCCHHH	43.81	30576142
284	Phosphorylation	PSSTDSDSKDDVKKE CCCCCCCCHHHHHHH	41.77	28555341
297	Phosphorylation	KESKKDATKDAKKVA HHHHHHHHHHHHHHH	39.32	-
302	Acetylation	DATKDAKKVAKKDTE HHHHHHHHHHHHHHH	49.50	7428749
305	Acetylation	KDAKKVAKKDTEKES HHHHHHHHHHHHHHH	54.92	7428757
308	Phosphorylation	KKVAKKDTEKESADS HHHHHHHHHHHHHHH	58.81	28258704
310	Ubiquitination	VAKKDTEKESADSKK HHHHHHHHHHHHHHH	60.09	-
312	O-linked_Glycosylation	KKDTEKESADSKKDA HHHHHHHHHHHHHHH	48.74	30379171
316	Ubiquitination	EKESADSKKDAKKNA HHHHHHHHHHHHHHH	56.04	-
329	Ubiquitination	NAKKDAKKDAKKNAK HHHHHHHHHHHHHHH	65.72	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CYLC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CYLC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CYLC2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CYLC2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.