dbPTM

3HAO_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	3HAO_HUMAN
UniProt AC	P46952
Protein Name	3-hydroxyanthranilate 3,4-dioxygenase {ECO:0000255\|HAMAP-Rule:MF_03019}
Gene Name	HAAO {ECO:0000255\|HAMAP-Rule:MF_03019, ECO:0000312\|HGNC:HGNC:4796}
Organism	Homo sapiens (Human).
Sequence Length	286
Subcellular Localization	Cytoplasm, cytosol .
Protein Description	Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate..
Protein Sequence	MERRLGVRAWVKENRGSFQPPVCNKLMHQEQLKVMFIGGPNTRKDYHIEEGEEVFYQLEGDMVLRVLEQGKHRDVVIRQGEIFLLPARVPHSPQRFANTVGLVVERRRLETELDGLRYYVGDTMDVLFEKWFYCKDLGTQLAPIIQEFFSSEQYRTGKPIPDQLLKEPPFPLSTRSIMEPMSLDAWLDSHHRELQAGTPLSLFGDTYETQVIAYGQGSSEGLRQNVDVWLWQLEGSSVVTMGGRRLSLAPDDSLLVLAGTSYAWERTQGSVALSVTQDPACKKPLG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	Phosphorylation	VERRRLETELDGLRY EEECCCEEHHCCCEE	46.57	-
236	Phosphorylation	WLWQLEGSSVVTMGG EEEEEECCEEEEECC	15.58	27732954
237	Phosphorylation	LWQLEGSSVVTMGGR EEEEECCEEEEECCE	31.31	27732954
240	Phosphorylation	LEGSSVVTMGGRRLS EECCEEEEECCEEEE	14.14	27732954
247	Phosphorylation	TMGGRRLSLAPDDSL EECCEEEEECCCCCE	22.22	28857561
253	Phosphorylation	LSLAPDDSLLVLAGT EEECCCCCEEEEECC	30.86	28192239
270	Phosphorylation	AWERTQGSVALSVTQ EEECCCCCEEEEECC	8.39	-
274	Phosphorylation	TQGSVALSVTQDPAC CCCCEEEEECCCCHH	17.24	-
276	Phosphorylation	GSVALSVTQDPACKK CCEEEEECCCCHHCC	24.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of 3HAO_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of 3HAO_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of 3HAO_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
GDIR1_HUMAN	ARHGDIA	physical	21900206

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of 3HAO_HUMAN

Related Literatures of Post-Translational Modification