TLS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLS1_HUMAN
• UniProt AC: Q9NZ63
• Protein Name: Telomere length and silencing protein 1 homolog {ECO:0000250|UniProtKB:Q10148}
• Gene Name: C9orf78
• Organism: Homo sapiens (Human).
• Sequence Length: 289
• Protein Description: Involved in the regulation of telomeric heterochromatin assembly and control of telomere length..
• Protein Sequence: MPVVRKIFRRRRGDSESEEDEQDSEEVRLKLEETREVQNLRKRPNGVSAVALLVGEKVQEETTLVDDPFQMKTGGMVDMKKLKERGKDKISEEEDLHLGTSFSAETNRRDEDADMMKYIETELKKRKGIVEHEEQKVKPKNAEDCLYELPENIRVSSAKKTEEMLSNQMLSGIPEVDLGIDAKIKNIISTEDAKARLLAEQQNKKKDSETSFVPTNMAVNYVQHNRFYHEELNAPIRRNKEEPKARPLRVGDTEKPEPERSPPNRKRPANEKATDDYHYEKFKKMNRRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	FRRRRGDSESEEDEQ HHHHCCCCCCCCCCC		29255136
17	Phosphorylation	RRRGDSESEEDEQDS HHCCCCCCCCCCCCC		29255136
24	Phosphorylation	SEEDEQDSEEVRLKL CCCCCCCCHHHHHHH		20164059
30	Ubiquitination	DSEEVRLKLEETREV CCHHHHHHHHHHHHH		29967540
48	Phosphorylation	RKRPNGVSAVALLVG HHCCCCCHHHHHHHC		28555341
62	Phosphorylation	GEKVQEETTLVDDPF CCCCCCCCEECCCCC		25463755
63	Phosphorylation	EKVQEETTLVDDPFQ CCCCCCCEECCCCCC		25463755
71	Sulfoxidation	LVDDPFQMKTGGMVD ECCCCCCCCCCCCCC		21406390
72	Ubiquitination	VDDPFQMKTGGMVDM CCCCCCCCCCCCCCH		32015554
73	Phosphorylation	DDPFQMKTGGMVDMK CCCCCCCCCCCCCHH		25463755
80	Acetylation	TGGMVDMKKLKERGK CCCCCCHHHHHHHCC		25953088
91	Phosphorylation	ERGKDKISEEEDLHL HHCCCCCCHHHHCCC		28985074
97	Ubiquitination	ISEEEDLHLGTSFSA CCHHHHCCCCCCCCC		24816145
100	Phosphorylation	EEDLHLGTSFSAETN HHHCCCCCCCCCCCC		25159151
101	Phosphorylation	EDLHLGTSFSAETNR HHCCCCCCCCCCCCC		25159151
103	Phosphorylation	LHLGTSFSAETNRRD CCCCCCCCCCCCCCC		26074081
106	Phosphorylation	GTSFSAETNRRDEDA CCCCCCCCCCCCCCH		26074081
117	Ubiquitination	DEDADMMKYIETELK CCCHHHHHHHHHHHH		24816145
118	Phosphorylation	EDADMMKYIETELKK CCHHHHHHHHHHHHH		28796482
118	Ubiquitination	EDADMMKYIETELKK CCHHHHHHHHHHHHH		24816145
121	Phosphorylation	DMMKYIETELKKRKG HHHHHHHHHHHHCCC		20068231
124	Ubiquitination	KYIETELKKRKGIVE HHHHHHHHHCCCCCC		29967540
125	Ubiquitination	YIETELKKRKGIVEH HHHHHHHHCCCCCCC		-
127	Acetylation	ETELKKRKGIVEHEE HHHHHHCCCCCCCCH		7681437
136	Ubiquitination	IVEHEEQKVKPKNAE CCCCCHHCCCCCCHH		33845483
136	Acetylation	IVEHEEQKVKPKNAE CCCCCHHCCCCCCHH		7681447
138	Ubiquitination	EHEEQKVKPKNAEDC CCCHHCCCCCCHHHH		24816145
140	Ubiquitination	EEQKVKPKNAEDCLY CHHCCCCCCHHHHHH		33845483
147	Phosphorylation	KNAEDCLYELPENIR CCHHHHHHHCCCCCC		21945579
156	Phosphorylation	LPENIRVSSAKKTEE CCCCCCCCCCHHHHH		30576142
157	Phosphorylation	PENIRVSSAKKTEEM CCCCCCCCCHHHHHH		30576142
160	Ubiquitination	IRVSSAKKTEEMLSN CCCCCCHHHHHHHHH		29967540
161	Phosphorylation	RVSSAKKTEEMLSNQ CCCCCHHHHHHHHHH		21712546
164	Sulfoxidation	SAKKTEEMLSNQMLS CCHHHHHHHHHHHHC		21406390
185	Ubiquitination	LGIDAKIKNIISTED CCCCHHHHCCCCCHH		24816145
185	2-Hydroxyisobutyrylation	LGIDAKIKNIISTED CCCCHHHHCCCCCHH		-
194	Ubiquitination	IISTEDAKARLLAEQ CCCCHHHHHHHHHHH		33845483
194	2-Hydroxyisobutyrylation	IISTEDAKARLLAEQ CCCCHHHHHHHHHHH		-
204	Ubiquitination	LLAEQQNKKKDSETS HHHHHHHCCCCCCCC		29967540
204	2-Hydroxyisobutyrylation	LLAEQQNKKKDSETS HHHHHHHCCCCCCCC		-
205	Ubiquitination	LAEQQNKKKDSETSF HHHHHHCCCCCCCCC		24816145
208	Phosphorylation	QQNKKKDSETSFVPT HHHCCCCCCCCCCCH		28555341
210	Phosphorylation	NKKKDSETSFVPTNM HCCCCCCCCCCCHHH		28555341
211	Phosphorylation	KKKDSETSFVPTNMA CCCCCCCCCCCHHHH		28555341
215	Phosphorylation	SETSFVPTNMAVNYV CCCCCCCHHHHHHHH		26552605
221	Phosphorylation	PTNMAVNYVQHNRFY CHHHHHHHHHCCCHH		28796482
224	Ubiquitination	MAVNYVQHNRFYHEE HHHHHHHCCCHHHHH		24816145
226	Methylation	VNYVQHNRFYHEELN HHHHHCCCHHHHHHC		-
228	Phosphorylation	YVQHNRFYHEELNAP HHHCCCHHHHHHCCC		28796482
235	Ubiquitination	YHEELNAPIRRNKEE HHHHHCCCCCCCCCC		24816145
244	Ubiquitination	RRNKEEPKARPLRVG CCCCCCCCCCCCCCC		24816145
252	Ubiquitination	ARPLRVGDTEKPEPE CCCCCCCCCCCCCCC		24816145
253	Phosphorylation	RPLRVGDTEKPEPER CCCCCCCCCCCCCCC		29255136
255	Ubiquitination	LRVGDTEKPEPERSP CCCCCCCCCCCCCCC		24816145
261	Phosphorylation	EKPEPERSPPNRKRP CCCCCCCCCCCCCCC		29255136
272	Ubiquitination	RKRPANEKATDDYHY CCCCCCCCCCCHHHH		24816145
274	Phosphorylation	RPANEKATDDYHYEK CCCCCCCCCHHHHHH		26074081
277	Phosphorylation	NEKATDDYHYEKFKK CCCCCCHHHHHHHHH		28796482
279	Phosphorylation	KATDDYHYEKFKKMN CCCCHHHHHHHHHHH		28796482
281	Ubiquitination	TDDYHYEKFKKMNRR CCHHHHHHHHHHHHC		29967540
281	Acetylation	TDDYHYEKFKKMNRR CCHHHHHHHHHHHHC		27452117

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:20804422

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
FKBP9_HUMAN	FKBP9	physical	22863883
HERC4_HUMAN	HERC4	physical	22863883
LIMD1_HUMAN	LIMD1	physical	22863883
NUBP2_HUMAN	NUBP2	physical	22863883
UBR7_HUMAN	UBR7	physical	22863883
OCRL_HUMAN	OCRL	physical	26186194
CE120_HUMAN	CEP120	physical	26186194
BTBD1_HUMAN	BTBD1	physical	26186194
BTBD2_HUMAN	BTBD2	physical	26186194
SYHC_HUMAN	HARS	physical	26344197
HNRH1_HUMAN	HNRNPH1	physical	26344197
TLS1_HUMAN	C9orf78	physical	26472760
U5S1_HUMAN	EFTUD2	physical	26472760
U520_HUMAN	SNRNP200	physical	26472760
PRP8_HUMAN	PRPF8	physical	26472760
CE120_HUMAN	CEP120	physical	28514442
BTBD1_HUMAN	BTBD1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.