NXPH3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NXPH3_HUMAN
• UniProt AC: O95157
• Protein Name: Neurexophilin-3
• Gene Name: NXPH3
• Organism: Homo sapiens (Human).
• Sequence Length: 252
• Subcellular Localization: Secreted .
• Protein Description: May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity)..
• Protein Sequence: MQLTRCCFVFLVQGSLYLVICGQDDGPPGSEDPERDDHEGQPRPRVPRKRGHISPKSRPMANSTLLGLLAPPGEAWGILGQPPNRPNHSPPPSAKVKKIFGWGDFYSNIKTVALNLLVTGKIVDHGNGTFSVHFQHNATGQGNISISLVPPSKAVEFHQEQQIFIEAKASKIFNCRMEWEKVERGRRTSLCTHDPAKICSRDHAQSSATWSCSQPFKVVCVYIAFYSTDYRLVQKVCPDYNYHSDTPYYPSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	PRKRGHISPKSRPMA CCCCCCCCCCCCCCC	22.17	27282143
57	Phosphorylation	RGHISPKSRPMANST CCCCCCCCCCCCCCC	45.03	27282143
62	N-linked_Glycosylation	PKSRPMANSTLLGLL CCCCCCCCCCCCEEE	29.31	UniProtKB CARBOHYD
98	Ubiquitination	PPSAKVKKIFGWGDF CCCHHHHEECCCCCH	46.37	29967540
106	Phosphorylation	IFGWGDFYSNIKTVA ECCCCCHHHHHHHHH	12.92	19835603
107	Phosphorylation	FGWGDFYSNIKTVAL CCCCCHHHHHHHHHH	31.88	19835603
127	N-linked_Glycosylation	GKIVDHGNGTFSVHF CEEEECCCCEEEEEE	42.80	UniProtKB CARBOHYD
137	N-linked_Glycosylation	FSVHFQHNATGQGNI EEEEEEECCCCCCEE	28.54	UniProtKB CARBOHYD
143	N-linked_Glycosylation	HNATGQGNISISLVP ECCCCCCEEEEEEEC	19.56	UniProtKB CARBOHYD
200	Phosphorylation	HDPAKICSRDHAQSS CCHHHHCCCCCCCCC	44.19	-
206	Phosphorylation	CSRDHAQSSATWSCS CCCCCCCCCCCCCCC	23.79	-
209	Phosphorylation	DHAQSSATWSCSQPF CCCCCCCCCCCCCCE	21.62	-
240	Phosphorylation	VQKVCPDYNYHSDTP HHHHCCCCCCCCCCC	11.63	30576142
242	Phosphorylation	KVCPDYNYHSDTPYY HHCCCCCCCCCCCCC	9.11	30576142
248	Phosphorylation	NYHSDTPYYPSG--- CCCCCCCCCCCC---	30.05	30576142
251	Phosphorylation	SDTPYYPSG------ CCCCCCCCC------	40.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NXPH3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NXPH3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NXPH3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PALD_HUMAN	PALD1	physical	26186194
TBA4A_HUMAN	TUBA4A	physical	26186194
TBA1A_HUMAN	TUBA1A	physical	26186194
SUFU_HUMAN	SUFU	physical	26186194
LMF1_HUMAN	LMF1	physical	26186194
DCP2_HUMAN	DCP2	physical	26186194
SUFU_HUMAN	SUFU	physical	28514442
PALD_HUMAN	PALD1	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
DCP2_HUMAN	DCP2	physical	28514442
TBA1A_HUMAN	TUBA1A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.