ACAP3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACAP3_HUMAN
• UniProt AC: Q96P50
• Protein Name: Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3
• Gene Name: ACAP3
• Organism: Homo sapiens (Human).
• Sequence Length: 834
• Protein Description: GTPase-activating protein for the ADP ribosylation factor family..
• Protein Sequence: MTVEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLSQQCQGDTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKETKKQFDKVREDLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQAKKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAPALEAPRRWRVQKCLRPHSSPRAPTARRKVRLEPVLPCVAALSSVGTLDRKFRRDSLFCPDELDSLFSYFDAGAAGAGPRSLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEEGAESEESSGEADGDTEAEAWGLADVRELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTLLRLARMAEEMREAEAAPGPPGALAGSPTELQFRRCIQEFISLHLEES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Ubiquitination	VEFEECVKDSPRFRA EEHHHHHCCCHHHEE	65.24	-
48	Ubiquitination	SGMVEAGKAYVSTSR HHHHHHCCCEEEHHH	43.52	-
50	Phosphorylation	MVEAGKAYVSTSRLF HHHHCCCEEEHHHHE	9.83	29759185
52	Phosphorylation	EAGKAYVSTSRLFVS HHCCCEEEHHHHEEE	14.16	29759185
59	Phosphorylation	STSRLFVSGVRDLSQ EHHHHEEECHHHHHH	25.00	29759185
84	Phosphorylation	CLQRFADSLQEVVNY HHHHHHHHHHHHHHH	28.64	22210691
91	Phosphorylation	SLQEVVNYHMILFDQ HHHHHHHHHHHHHHH	4.91	22210691
109	Phosphorylation	SVRQQLQSFVKEDVR HHHHHHHHHHHHHHH	40.37	22210691
121	Phosphorylation	DVRKFKETKKQFDKV HHHHHHHHHHHHHHH	44.10	26657352
135	Phosphorylation	VREDLELSLVRNAQA HHHHHHHHHHHCCCC	18.55	24719451
189	Phosphorylation	KKFEILDSMLSFMHA HHHHHHHHHHHHHHH	20.41	24043423
192	Phosphorylation	EILDSMLSFMHAQSS HHHHHHHHHHHHHHH	16.33	24043423
198	Phosphorylation	LSFMHAQSSFFQQGY HHHHHHHHHHHHHHH	29.87	24043423
199	Phosphorylation	SFMHAQSSFFQQGYS HHHHHHHHHHHHHHH	20.28	24043423
205	Phosphorylation	SSFFQQGYSLLHQLD HHHHHHHHHHHHHHC	7.57	24043423
206	Phosphorylation	SFFQQGYSLLHQLDP HHHHHHHHHHHHHCH	31.14	24043423
214	Phosphorylation	LLHQLDPYMKKLAAE HHHHHCHHHHHHHHH	22.64	24043423
233	Ubiquitination	VIDSAVEKREMERKH HHHHHHHHHHHHHHH	47.24	-
247	Phosphorylation	HAAIQQRTLLQDFSY HHHHHHHHHHHHCCC	27.73	27251275
280	Phosphorylation	GYLFKRASNAFKTWN EEEEECHHCHHHHCC	32.49	24719451
336	Phosphorylation	RFCFEVLSPTKSCML HHHHHHCCCCCCHHC	35.38	24719451
349	Ubiquitination	MLQADSEKLRQAWVQ HCCCCHHHHHHHHHH	53.58	-
364	Phosphorylation	AVQASIASAYRESPD HHHHHHHHHHHHCCC	24.94	28348404
369	Phosphorylation	IASAYRESPDSCYSE HHHHHHHCCCCHHHH	25.63	28348404
381	Phosphorylation	YSERLDRTASPSTSS HHHHCCCCCCCCCCC	31.02	21815630
383	Phosphorylation	ERLDRTASPSTSSID HHCCCCCCCCCCCCC	20.83	21712546
385	Phosphorylation	LDRTASPSTSSIDSA CCCCCCCCCCCCCCC	38.12	25850435
386	Phosphorylation	DRTASPSTSSIDSAT CCCCCCCCCCCCCCC	29.85	25850435
387	Phosphorylation	RTASPSTSSIDSATD CCCCCCCCCCCCCCC	29.63	29396449
388	Phosphorylation	TASPSTSSIDSATDT CCCCCCCCCCCCCCH	30.42	22617229
391	Phosphorylation	PSTSSIDSATDTRER CCCCCCCCCCCHHHC	31.25	25849741
393	Phosphorylation	TSSIDSATDTRERGV CCCCCCCCCHHHCCC	41.68	29396449
395	Phosphorylation	SIDSATDTRERGVKG CCCCCCCHHHCCCCC	30.03	28985074
396	Methylation	IDSATDTRERGVKGE CCCCCCHHHCCCCCH	34.13	-
398	Methylation	SATDTRERGVKGESV CCCCHHHCCCCCHHH	52.49	-
401	Ubiquitination	DTRERGVKGESVLQR CHHHCCCCCHHHHHH	60.84	-
404	Phosphorylation	ERGVKGESVLQRVQS HCCCCCHHHHHHHHH	36.47	30576142
411	Phosphorylation	SVLQRVQSVAGNSQC HHHHHHHHHHCCCCC	15.86	27251275
496	Phosphorylation	GAGSRKPTASSSRQD CCCCCCCCCCCCCCC	42.05	29083192
498	Phosphorylation	GSRKPTASSSRQDKE CCCCCCCCCCCCCHH	31.18	29083192
499	Phosphorylation	SRKPTASSSRQDKEA CCCCCCCCCCCCHHH	27.38	29083192
500	Phosphorylation	RKPTASSSRQDKEAW CCCCCCCCCCCHHHH	31.31	29083192
543	Phosphorylation	QKCLRPHSSPRAPTA HHHCCCCCCCCCCCH	44.73	30266825
544	Phosphorylation	KCLRPHSSPRAPTAR HHCCCCCCCCCCCHH	18.51	30266825
813	Phosphorylation	PPGALAGSPTELQFR CCCCCCCCCCHHHHH	24.04	22210691
815	Phosphorylation	GALAGSPTELQFRRC CCCCCCCCHHHHHHH	51.53	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACAP3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACAP3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACAP3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of ACAP3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.