dbPTM

GPT_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	GPT_HUMAN
UniProt AC	Q9H3H5
Protein Name	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Gene Name	DPAGT1 {ECO:0000303\|PubMed:12872255, ECO:0000303\|PubMed:22742743, ECO:0000303\|PubMed:29459785, ECO:0000312\|HGNC:HGNC:2995}
Organism	Homo sapiens (Human).
Sequence Length	408
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol..
Protein Sequence	MWAFSELPMPLLINLIVSLLGFVATVTLIPAFRGHFIAARLCGQDLNKTSRQQIPESQGVISGAVFLIILFCFIPFPFLNCFVKEQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRPILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDCRDDHVFSLYFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAVVGILGHFSKTMLLFFMPQVFNFLYSLPQLLHIIPCPRHRIPRLNIKTGKLEMSYSKFKTKSLSFLGTFILKVAESLQLVTVHQSETEDGEFTECNNMTLINLLLKVLGPIHERNLTLLLLLLQILGSAITFSIRYQLVRLFYDV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40 (in isoform 2)	Ubiquitination	-	22.84	21906983
48	Ubiquitination	LCGQDLNKTSRQQIP HHCCCCCHHHHHHCC	55.99	2190698
48 (in isoform 1)	Ubiquitination	-	55.99	21906983
146	N-linked_Glycosylation	VYFTNFGNTTIVVPK EEEECCCCEEEEECC	29.88	UniProtKB CARBOHYD
311	Phosphorylation	IPRLNIKTGKLEMSY CCCCCCCCCCEEECH	35.43	-
313	Ubiquitination	RLNIKTGKLEMSYSK CCCCCCCCEEECHHH	46.64	-
317	Phosphorylation	KTGKLEMSYSKFKTK CCCCEEECHHHHCCC	19.51	26074081
318	Phosphorylation	TGKLEMSYSKFKTKS CCCEEECHHHHCCCC	17.99	26074081
319	Phosphorylation	GKLEMSYSKFKTKSL CCEEECHHHHCCCCH	25.06	26074081
320	Ubiquitination	KLEMSYSKFKTKSLS CEEECHHHHCCCCHH	42.52	-
320	Acetylation	KLEMSYSKFKTKSLS CEEECHHHHCCCCHH	42.52	26822725

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of GPT_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of GPT_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of GPT_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MFSD3_HUMAN	MFSD3	physical	21988832
SIA4B_HUMAN	ST3GAL2	physical	28514442
STX4_HUMAN	STX4	physical	28514442
RAB21_HUMAN	RAB21	physical	28514442
SCPDL_HUMAN	SCCPDH	physical	28514442
LX12B_HUMAN	ALOX12B	physical	28514442

Drug and Disease Associations

Kegg Disease
H00118	Congenital disorders of glycosylation (CDG) type I
OMIM Disease
608093	Congenital disorder of glycosylation 1J (CDG1J)
614750	Myasthenic syndrome, congenital, 13 (CMS13)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of GPT_HUMAN

Related Literatures of Post-Translational Modification