PDCD2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PDCD2_HUMAN
• UniProt AC: Q16342
• Protein Name: Programmed cell death protein 2
• Gene Name: PDCD2
• Organism: Homo sapiens (Human).
• Sequence Length: 344
• Subcellular Localization: Nucleus .
• Protein Description: May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation..
• Protein Sequence: MAAAGARPVELGFAESAPAWRLRSEQFPSKVGGRPAWLGAAGLPGPQALACELCGRPLSFLLQVYAPLPGRPDAFHRCIFLFCCREQPCCAGLRVFRNQLPRKNDFYSYEPPSENPPPETGESVCLQLKSGAHLCRVCGCLGPKTCSRCHKAYYCSKEHQTLDWRLGHKQACAQPDHLDHIIPDHNFLFPEFEIVIETEDEIMPEVVEKEDYSEIIGSMGEALEEELDSMAKHESREDKIFQKFKTQIALEPEQILRYGRGIAPIWISGENIPQEKDIPDCPCGAKRILEFQVMPQLLNYLKADRLGKSIDWGILAVFTCAESCSLGTGYTEEFVWKQDVTDTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAAGARPV ------CCCCCCCCC	13.15	-
30	Ubiquitination	RSEQFPSKVGGRPAW CHHHCCHHCCCCCCC	45.17	-
30	Ubiquitination	RSEQFPSKVGGRPAW CHHHCCHHCCCCCCC	45.17	-
103	Ubiquitination	FRNQLPRKNDFYSYE HHCCCCCCCCCCCCC	59.95	-
103	Ubiquitination	FRNQLPRKNDFYSYE HHCCCCCCCCCCCCC	59.95	-
129	Ubiquitination	ESVCLQLKSGAHLCR CCEEHHCCCCCHHHH	33.60	-
129	Ubiquitination	ESVCLQLKSGAHLCR CCEEHHCCCCCHHHH	33.60	-
144	Ubiquitination	VCGCLGPKTCSRCHK HCCCCCHHHHCCCCH	61.44	-
144	Ubiquitination	VCGCLGPKTCSRCHK HCCCCCHHHHCCCCH	61.44	-
151	Ubiquitination	KTCSRCHKAYYCSKE HHHCCCCHHHHCCCC	41.53	-
157	Sumoylation	HKAYYCSKEHQTLDW CHHHHCCCCCCCCCC	56.51	-
157	Ubiquitination	HKAYYCSKEHQTLDW CHHHHCCCCCCCCCC	56.51	-
157	Ubiquitination	HKAYYCSKEHQTLDW CHHHHCCCCCCCCCC	56.51	-
157	Sumoylation	HKAYYCSKEHQTLDW CHHHHCCCCCCCCCC	56.51	-
239	Sumoylation	KHESREDKIFQKFKT HCCCHHHHHHHHHHH	40.44	-
239	Ubiquitination	KHESREDKIFQKFKT HCCCHHHHHHHHHHH	40.44	-
239	Sumoylation	KHESREDKIFQKFKT HCCCHHHHHHHHHHH	40.44	-
243	Ubiquitination	REDKIFQKFKTQIAL HHHHHHHHHHHHHCC	37.77	-
245	Ubiquitination	DKIFQKFKTQIALEP HHHHHHHHHHHCCCH	46.70	-
276	Ubiquitination	GENIPQEKDIPDCPC CCCCCCCCCCCCCCC	56.56	-
286	Ubiquitination	PDCPCGAKRILEFQV CCCCCCCHHHHHHCH	25.84	-
300	Phosphorylation	VMPQLLNYLKADRLG HHHHHHHHHHHHHCC	15.00	22817900
302	Ubiquitination	PQLLNYLKADRLGKS HHHHHHHHHHHCCCC	37.57	-
341	Phosphorylation	FVWKQDVTDTP---- EEEEECCCCCC----	42.31	26074081
343	Phosphorylation	WKQDVTDTP------ EEECCCCCC------	22.87	26074081

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	PRKN	O60260	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PDCD2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PDCD2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HCFC1_HUMAN	HCFC1	physical	12149646
NCOR1_HUMAN	NCOR1	physical	12149646
PRKN_HUMAN	PARK2	physical	19146857

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
PubMed: 19413330