KLHL8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLHL8_HUMAN
• UniProt AC: Q9P2G9
• Protein Name: Kelch-like protein 8
• Gene Name: KLHL8
• Organism: Homo sapiens (Human).
• Sequence Length: 620
• Protein Description: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN..
• Protein Sequence: MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCSCLTSQIRDVGHGSNNVVDCM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASDSMSSK ------CCCCCCCHH	23.26	22814378
3	Phosphorylation	-----MASDSMSSKQ -----CCCCCCCHHH	28.99	21601212
9	Ubiquitination	ASDSMSSKQARNHIT CCCCCCHHHHHHHHH	40.44	-
28	Ubiquitination	QQQHQQIKNRSSISD HHHHHHHHCCCCCCC	41.80	21890473
31	Phosphorylation	HQQIKNRSSISDGDG HHHHHCCCCCCCCCC	41.22	28348404
32	Phosphorylation	QQIKNRSSISDGDGE HHHHCCCCCCCCCCC	23.91	28348404
34	Phosphorylation	IKNRSSISDGDGEDS HHCCCCCCCCCCCCC	37.17	28348404
41	Phosphorylation	SDGDGEDSFIFEANE CCCCCCCCEEEECHH	18.88	28348404
126	Phosphorylation	EDLVKFVYSSRLTLT HHHHHHHHHCCCEEE	12.22	29759185
127	Phosphorylation	DLVKFVYSSRLTLTV HHHHHHHHCCCEEEE	12.04	29759185
152	Ubiquitination	CILQVELVARACCEY HHHHHHHHHHHHHHH	1.83	-
171	Ubiquitination	FHPSNCLAVRAFAES CCHHHHHHHHHHHHH	7.31	-
228	Ubiquitination	DLNIENEKQVYNAAI CCCCCCHHHHHHHHH	57.56	21890473
247	Ubiquitination	ANPQHHSKWLDETLA HCHHHHHHHHHHHHH	47.63	-
277	Ubiquitination	VAKEQIVKQNLKCRD HHHHHHHHCCCCHHH	34.79	-
307	Phosphorylation	AVPDFEYSIRTTPRK CCCCCCEEEECCCCC	9.82	24719451
343	Ubiquitination	IECYSINKNSWFFGP EEEEEECCCCEECCC	51.17	-
392	Ubiquitination	MFDPLTNKWMMKASM CCCCCCCHHHHHHHC	31.09	-
410	Ubiquitination	RRGIALASLGGPIYA CCCEEEEECCCCEEE	28.53	21890473
433	Phosphorylation	CFNDVERYDIESDQW CCCCHHHEECCCCCC	14.04	-
457	Ubiquitination	RGGVGSVALVNHVYA CCCCCCEEEEEEEEE	13.90	21890473
486	Ubiquitination	RYDPHLDKWIEVKEM CCCCCHHHHEEHHHH	57.33	21890473
491	Ubiquitination	LDKWIEVKEMGQRRA HHHHEEHHHHHHHCC	29.23	21890473
533	Ubiquitination	RYDPRSNKWDYVAAL CCCCCCCCCCEEEEE	42.56	21890473
541	Phosphorylation	WDYVAALTTPRGGVG CCEEEEEECCCCCCC	29.99	24719451
542	Phosphorylation	DYVAALTTPRGGVGI CEEEEEECCCCCCCH	16.31	-
551	Phosphorylation	RGGVGIATVMGKIFA CCCCCHHEEEEEEEE	14.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLHL8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLHL8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLHL8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CUL3_HUMAN	CUL3	physical	19158078
RAPSN_HUMAN	RAPSN	physical	19158078

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.