GTSF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GTSF1_HUMAN
• UniProt AC: Q8WW33
• Protein Name: Gametocyte-specific factor 1
• Gene Name: GTSF1
• Organism: Homo sapiens (Human).
• Sequence Length: 167
• Subcellular Localization: Cytoplasm .
• Protein Description: Required for spermatogenesis and is involved in the suppression of retrotransposon transcription in male germ cells..
• Protein Sequence: MEETYTDSLDPEKLLQCPYDKNHQIRACRFPYHLIKCRKNHPDVASKLATCPFNARHQVPRAEISHHISSCDDRSCIEQDVVNQTRSLRQETLAESTWQCPPCDEDWDKDLWEQTSTPFVWGTTHYSDNNSPASNIVTEHKNNLASGMRVPKSLPYVLPWKNNGNAQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEETYTDSLDPE ---CCCCCCCCCCHH	16.30	-
8	Phosphorylation	MEETYTDSLDPEKLL CCCCCCCCCCHHHHH	27.20	23186163
32	Phosphorylation	IRACRFPYHLIKCRK EEHHCCCHHHHHHHC	13.42	-
36	Ubiquitination	RFPYHLIKCRKNHPD CCCHHHHHHHCCCCC	34.05	-
39	Ubiquitination	YHLIKCRKNHPDVAS HHHHHHHCCCCCHHH	69.91	-
47	Acetylation	NHPDVASKLATCPFN CCCCHHHHHCCCCCC	32.19	25953088
47	Ubiquitination	NHPDVASKLATCPFN CCCCHHHHHCCCCCC	32.19	-
50	Phosphorylation	DVASKLATCPFNARH CHHHHHCCCCCCCCC	31.02	-
69	Phosphorylation	AEISHHISSCDDRSC HHHCHHCCCCCCCHH	22.13	30576142
75	Phosphorylation	ISSCDDRSCIEQDVV CCCCCCCHHHHHHHH	26.83	30576142
87	Phosphorylation	DVVNQTRSLRQETLA HHHHHHHHHHHHHHH	31.15	-
115	Phosphorylation	DKDLWEQTSTPFVWG CHHHHHHCCCCEEEE	24.05	23898821
116	Phosphorylation	KDLWEQTSTPFVWGT HHHHHHCCCCEEEEC	33.50	23898821
117	Phosphorylation	DLWEQTSTPFVWGTT HHHHHCCCCEEEECC	24.92	23898821
123	Phosphorylation	STPFVWGTTHYSDNN CCCEEEECCCCCCCC	8.49	23898821
124	Phosphorylation	TPFVWGTTHYSDNNS CCEEEECCCCCCCCC	18.19	23898821
126	Phosphorylation	FVWGTTHYSDNNSPA EEEECCCCCCCCCCH	18.67	30576142
127	Phosphorylation	VWGTTHYSDNNSPAS EEECCCCCCCCCCHH	26.68	30576142
131	Phosphorylation	THYSDNNSPASNIVT CCCCCCCCCHHHHHH	28.26	30576142
134	Phosphorylation	SDNNSPASNIVTEHK CCCCCCHHHHHHCCC	30.39	23898821
138	Phosphorylation	SPASNIVTEHKNNLA CCHHHHHHCCCCCCC	28.68	23898821
152	Ubiquitination	ASGMRVPKSLPYVLP CCCCCCCCCCCCEEC	62.86	21890473
153	Phosphorylation	SGMRVPKSLPYVLPW CCCCCCCCCCCEECC	28.62	22617229
156	Phosphorylation	RVPKSLPYVLPWKNN CCCCCCCCEECCCCC	21.66	23917254
161	Ubiquitination	LPYVLPWKNNGNAQ- CCCEECCCCCCCCC-	38.30	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GTSF1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GTSF1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GTSF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RGP1_HUMAN	RGP1	physical	28514442
MK14_HUMAN	MAPK14	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.