AGAP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGAP5_HUMAN
• UniProt AC: A6NIR3
• Protein Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 5
• Gene Name: AGAP5
• Organism: Homo sapiens (Human).
• Sequence Length: 686
• Protein Description: Putative GTPase-activating protein..
• Protein Sequence: MGNILTCCVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGEDLHMHHIRDQEMPEALEFSLSANPEASTIFQRNSQTDALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTERFSQQYSSCSTIFLDDSTASQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHITKNRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSHPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLRTSTIKVPGKWPSLATSACAPISSSKSNGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDECV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
147	Phosphorylation	QQYSSCSTIFLDDST HHHCCCEEEEECCCC	21.78	23663014
241	Phosphorylation	PPTANTPTPVCKRSM CCCCCCCCCCCCHHH	26.73	27067055
247	Phosphorylation	PTPVCKRSMRWSNLF CCCCCCHHHCHHHHC	9.74	27067055
264	Methylation	EKGSHPDKERKAPEN CCCCCCCCCCCCCCC	64.96	-
304	Phosphorylation	LKTWKKKYVTLCSNG HHHCHHHEEEECCCC	13.93	7459045
315	Phosphorylation	CSNGVLTYYSSLGDY CCCCEEHHHHHHHHH	9.37	-
316	Phosphorylation	SNGVLTYYSSLGDYM CCCEEHHHHHHHHHH	6.12	-
322	Phosphorylation	YYSSLGDYMKNIHKK HHHHHHHHHHHHHHH	14.27	7459053
336	Phosphorylation	KEIDLRTSTIKVPGK HCCEECCCEEECCCC	23.00	24719451
356	Phosphorylation	TSACAPISSSKSNGL CHHCCCCCCCCCCCC	27.74	22210691
440	Phosphorylation	AWVQAIQSQILASLQ HHHHHHHHHHHHHHH	17.05	-
454	Phosphorylation	QSCESSKSKSQLTSQ HHHCCCCCHHHCCCH	39.21	29888752
456	Phosphorylation	CESSKSKSQLTSQSE HCCCCCHHHCCCHHH	37.20	29888752
459	Phosphorylation	SKSKSQLTSQSEAMA CCCHHHCCCHHHHHH	19.65	29888752
460	Phosphorylation	KSKSQLTSQSEAMAL CCHHHCCCHHHHHHH	40.06	29888752
462	Phosphorylation	KSQLTSQSEAMALQS HHHCCCHHHHHHHHH	27.39	29888752
469	Phosphorylation	SEAMALQSIQNMRGN HHHHHHHHHHHHCCC	27.30	29888752
569	Phosphorylation	EKERWIRSKYEEKLF HHHHHHHHHHHHHHC	30.38	23401153
626	Phosphorylation	CGEGDGCTALHLACR CCCCCCCHHHHHHHH	37.47	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGAP5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGAP5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGAP5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AGAP5_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.