AGAP4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AGAP4_HUMAN
• UniProt AC: Q96P64
• Protein Name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4 {ECO:0000312|HGNC:HGNC:23459}
• Gene Name: AGAP4 {ECO:0000312|HGNC:HGNC:23459}
• Organism: Homo sapiens (Human).
• Sequence Length: 663
• Protein Description: Putative GTPase-activating protein..
• Protein Sequence: MGNILTCRVHPSVSLEFDQQQGSVCPSESEIYEAGAGDRMAGAPMAAAVQPAEVTVEVGEDLHMHHVRDREMPEALEFNPSANPEASTIFQRNSQTDVVEIRRSNCTNHVSTVRFSQQYSLCSTIFLDDSTAIQHYLTMTIISVTLEIPHHITQRDADRSLSIPDEQLHSFAVSTVHIMKKRNGGGSLNNYSSSIPSTPSTSQEDPQFSVPPTANTPTPVCKRSMRWSNLFTSEKGSDPDKERKAPENHADTIGSGRAIPIKQGMLLKRSGKWLKTWKKKYVTLCSNGVLTYYSSLGDYMKNIHKKEIDLQTSTIKVPGKWPSLATSACTPISTSKSNGLSKDMDTGLGDSICFSPSISSTTSPKLNPPPSPHANKKKHLKKKSTNNFMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSKAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSIGNDLANSIWEGSSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQYGCPDKCV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
111	Phosphorylation	SNCTNHVSTVRFSQQ CCCCCCCCEEEEEHH	17.40	29083192
112	Phosphorylation	NCTNHVSTVRFSQQY CCCCCCCEEEEEHHH	18.02	29083192
218	Phosphorylation	PPTANTPTPVCKRSM CCCCCCCCCCCCHHH	26.73	27067055
224	Phosphorylation	PTPVCKRSMRWSNLF CCCCCCHHHCHHHHC	9.74	27067055
232	Phosphorylation	MRWSNLFTSEKGSDP HCHHHHCCCCCCCCC	38.86	-
281	Phosphorylation	LKTWKKKYVTLCSNG HHHCHHHEEEECCCC	13.93	7459045
292	Phosphorylation	CSNGVLTYYSSLGDY CCCCEEHHHHHHHHH	9.37	-
293	Phosphorylation	SNGVLTYYSSLGDYM CCCEEHHHHHHHHHH	6.12	-
299	Phosphorylation	YYSSLGDYMKNIHKK HHHHHHHHHHHHHHH	14.27	7459053
312	Phosphorylation	KKEIDLQTSTIKVPG HHCCEEEECEEECCC	34.82	-
330	Phosphorylation	SLATSACTPISTSKS CCCCCCCCCCCCCCC	24.31	30576142
333	Phosphorylation	TSACTPISTSKSNGL CCCCCCCCCCCCCCC	28.03	30576142
335	Phosphorylation	ACTPISTSKSNGLSK CCCCCCCCCCCCCCC	27.57	46501681
341	Phosphorylation	TSKSNGLSKDMDTGL CCCCCCCCCCCCCCC	28.18	30576142
417	Phosphorylation	AWVQAIQSQILASLQ HHHHHHHHHHHHHHH	17.05	-
433	Phosphorylation	CESSKSKSQLTSQSK HCCCCCHHHHCHHHH	37.20	22210691
446	Phosphorylation	SKAMALQSIQNMRGN HHHHHHHHHHHHCCC	27.30	22210691
546	Phosphorylation	EKERWIRSKYEEKLF HHHHHHHHHHHHHHC	30.38	23401153
603	Phosphorylation	CGEGDGCTALHLACR CCCCCCCHHHHHHHH	37.47	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AGAP4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AGAP4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AGAP4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AGAP4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.