POPD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: POPD1_HUMAN
• UniProt AC: Q8NE79
• Protein Name: Blood vessel epicardial substance {ECO:0000312|HGNC:HGNC:1152}
• Gene Name: BVES {ECO:0000312|HGNC:HGNC:1152}
• Organism: Homo sapiens (Human).
• Sequence Length: 360
• Subcellular Localization: Lateral cell membrane . Cell junction, tight junction . Membrane ; Multi-pass membrane protein . Cell membrane, sarcolemma . Membrane, caveola . Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movem
• Protein Description: Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. [PubMed: 16188940 Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density]
• Protein Sequence: MNYTESSPLRESTAIGFTPELESIIPVPSNKTTCENWREIHHLVFHVANICFAVGLVIPTTLHLHMIFLRGMLTLGCTLYIVWATLYRCALDIMIWNSVFLGVNILHLSYLLYKKRPVKIEKELSGMYRRLFEPLRVPPDLFRRLTGQFCMIQTLKKGQTYAAEDKTSVDDRLSILLKGKMKVSYRGHFLHNIYPCAFIDSPEFRSTQMHKGEKFQVTIIADDNCRFLCWSRERLTYFLESEPFLYEIFRYLIGKDITNKLYSLNDPTLNDKKAKKLEHQLSLCTQISMLEMRNSIASSSDSDDGLHQFLRGTSSMSSLHVSSPHQRASAKMKPIEEGAEDDDDVFEPASPNTLKVHQLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	N-linked_Glycosylation	------MNYTESSPL ------CCCCCCCCC	53.05	UniProtKB CARBOHYD
3	Phosphorylation	-----MNYTESSPLR -----CCCCCCCCCC	15.58	-
6	Phosphorylation	--MNYTESSPLREST --CCCCCCCCCCCCC	29.47	22210691
7	Phosphorylation	-MNYTESSPLRESTA -CCCCCCCCCCCCCC	23.01	22210691
30	N-linked_Glycosylation	SIIPVPSNKTTCENW HCEECCCCCCCCCCH	39.35	UniProtKB CARBOHYD
122	Acetylation	KRPVKIEKELSGMYR CCCCCCHHHHCHHHH	68.38	19813459
194	Phosphorylation	GHFLHNIYPCAFIDS CCCHHCCCCCEEECC	9.51	-
295	Phosphorylation	SMLEMRNSIASSSDS HHHHHHHHHHCCCCC	14.79	30177828
298	Phosphorylation	EMRNSIASSSDSDDG HHHHHHHCCCCCCCC	28.80	25850435
299	Phosphorylation	MRNSIASSSDSDDGL HHHHHHCCCCCCCCH	29.19	25850435
300	Phosphorylation	RNSIASSSDSDDGLH HHHHHCCCCCCCCHH	38.34	25850435
302	Phosphorylation	SIASSSDSDDGLHQF HHHCCCCCCCCHHHH	39.28	25850435
313	Phosphorylation	LHQFLRGTSSMSSLH HHHHHHCCCCCCCCC	15.93	22210691
314	Phosphorylation	HQFLRGTSSMSSLHV HHHHHCCCCCCCCCC	27.20	24117733
315	Phosphorylation	QFLRGTSSMSSLHVS HHHHCCCCCCCCCCC	23.63	24117733
317	Phosphorylation	LRGTSSMSSLHVSSP HHCCCCCCCCCCCCH	31.53	24117733
318	Phosphorylation	RGTSSMSSLHVSSPH HCCCCCCCCCCCCHH	17.53	24117733
322	Phosphorylation	SMSSLHVSSPHQRAS CCCCCCCCCHHHHHC	27.66	24117733
323	Phosphorylation	MSSLHVSSPHQRASA CCCCCCCCHHHHHCC	25.88	24117733
350	Phosphorylation	DDVFEPASPNTLKVH CCCCCCCCCCCEEEE	29.42	26657352
353	Phosphorylation	FEPASPNTLKVHQLP CCCCCCCCEEEECCC	31.19	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of POPD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of POPD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of POPD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBAC1_HUMAN	UBAC1	physical	26186194
RN123_HUMAN	RNF123	physical	26186194
RN123_HUMAN	RNF123	physical	28514442
UBAC1_HUMAN	UBAC1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.