PALM3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PALM3_HUMAN
• UniProt AC: A6NDB9
• Protein Name: Paralemmin-3
• Gene Name: PALM3
• Organism: Homo sapiens (Human).
• Sequence Length: 673
• Subcellular Localization: Cytoplasm. Cell membrane; Lipid-anchor.
• Protein Description: ATP-binding protein, which may act as a adapter in the Toll-like receptor (TLR) signaling..
• Protein Sequence: MAESSLYRQRLEVIAEKRRLQEEIRAARREVEEEKLRVERLKRKSLRERWLMDGAAAVPEPSEDPTSKDPQSPEGQAQARIRNLEDSLFTLQSQLQLLQSASTGAQHKPSGRPSWRRQGHRPLSQSIVEAGSVGQTDLNKRASLPAGLVGTPPESPSEPREDVLGFLPGPRQVPGAAGDSSEANGPCPSPIPTPEQGLSQRAVPSEGRVGEAKGGGVVSVVWEGLRATEDCATGATGPELEAKVEEVVLEAIGDRKGAGSLELPAWVKEDRGIVEVVWEGVGGSDAEAMGEIGRVPEVVQTSSPRLQERLEAAASIEGEDVPQGSPEGDGQGGSGGEEGSFIWVERVTLSEEWEELLVEGLEGPEVAGRERGDESPLGAEGAKTGGGEETWEAEKRKAEESMGIGSEEKPGTGRDEAEMSPVVERKGGEKKLELESRGSAEKLGTEREGGEEPLGIERKVEGHLRAEKEGDEEKRGAEEEEVEEPLGVEKKGGEEEPEATKEPLEAERKGGEETLEAEKRGGEESLETEKTQGTEGDLNLEQGSREGSESQAEEMNEAGPPLEANTETRPEKEGPQPQEKPVGALEEEGVKPQTAAEGQGPLGDATPLLAETPAPEQPAECQPLLQGEGPSANPSAHPVPTYAPARQPEPSAPTEGEEASGPKQKTCQCCAVM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAESSLYRQRL ----CCCHHHHHHHH	18.99	29978859
5	Phosphorylation	---MAESSLYRQRLE ---CCCHHHHHHHHH	22.41	29978859
7	Phosphorylation	-MAESSLYRQRLEVI -CCCHHHHHHHHHHH	13.47	29978859
66	Phosphorylation	PEPSEDPTSKDPQSP CCCCCCCCCCCCCCH	61.81	28857561
67	Phosphorylation	EPSEDPTSKDPQSPE CCCCCCCCCCCCCHH	40.21	28857561
72	Phosphorylation	PTSKDPQSPEGQAQA CCCCCCCCHHHHHHH	30.24	21815630
114	Phosphorylation	HKPSGRPSWRRQGHR CCCCCCCCHHHCCCC	31.67	26091039
124	Phosphorylation	RQGHRPLSQSIVEAG HCCCCCCCHHHHHCC	25.27	26503892
126	Phosphorylation	GHRPLSQSIVEAGSV CCCCCCHHHHHCCCC	25.81	30266825
132	Phosphorylation	QSIVEAGSVGQTDLN HHHHHCCCCCCCCHH	30.07	21406692
136	Phosphorylation	EAGSVGQTDLNKRAS HCCCCCCCCHHHCCC	36.20	21406692
143	Phosphorylation	TDLNKRASLPAGLVG CCHHHCCCCCCCCCC	38.63	26503892
151	Phosphorylation	LPAGLVGTPPESPSE CCCCCCCCCCCCCCC	28.35	26503892
155	Phosphorylation	LVGTPPESPSEPRED CCCCCCCCCCCCHHH	39.23	26503892
157	Phosphorylation	GTPPESPSEPREDVL CCCCCCCCCCHHHCC	70.30	30266825
180	Phosphorylation	VPGAAGDSSEANGPC CCCCCCCCCCCCCCC	29.21	30266825
181	Phosphorylation	PGAAGDSSEANGPCP CCCCCCCCCCCCCCC	45.53	26657352
189	Phosphorylation	EANGPCPSPIPTPEQ CCCCCCCCCCCCHHC	42.02	26657352
193	Phosphorylation	PCPSPIPTPEQGLSQ CCCCCCCCHHCCCCC	39.93	28857561
205	Phosphorylation	LSQRAVPSEGRVGEA CCCCCCCCCCCCCCC	46.19	24719451
260	Phosphorylation	GDRKGAGSLELPAWV CCCCCCCCCCCCEEE	20.38	30266825
301	Phosphorylation	RVPEVVQTSSPRLQE CCCHHHCCCCHHHHH	21.40	30266825
302	Phosphorylation	VPEVVQTSSPRLQER CCHHHCCCCHHHHHH	22.66	30266825
303	Phosphorylation	PEVVQTSSPRLQERL CHHHCCCCHHHHHHH	19.89	19664994
315	Phosphorylation	ERLEAAASIEGEDVP HHHHHHHHCCCCCCC	19.22	22798277
325	Phosphorylation	GEDVPQGSPEGDGQG CCCCCCCCCCCCCCC	17.96	22798277
334	Phosphorylation	EGDGQGGSGGEEGSF CCCCCCCCCCCCCCE	50.91	22798277
340	Phosphorylation	GSGGEEGSFIWVERV CCCCCCCCEEEEEEE	19.48	22798277
375	Phosphorylation	GRERGDESPLGAEGA CCCCCCCCCCCCCCC	30.11	29255136
401	Phosphorylation	EKRKAEESMGIGSEE HHHHHHHHCCCCCCC	17.51	28857561
406	Phosphorylation	EESMGIGSEEKPGTG HHHCCCCCCCCCCCC	40.43	23186163
412	Phosphorylation	GSEEKPGTGRDEAEM CCCCCCCCCCCHHHH	37.26	28258704
420	Phosphorylation	GRDEAEMSPVVERKG CCCHHHHCCEEEECC	13.17	30266825
436	Phosphorylation	EKKLELESRGSAEKL EEEEEEEECCCHHHH	55.34	25849741
439	Phosphorylation	LELESRGSAEKLGTE EEEEECCCHHHHCCC	31.95	22617229
445	Phosphorylation	GSAEKLGTEREGGEE CCHHHHCCCCCCCCC	42.16	24719451
514	Phosphorylation	ERKGGEETLEAEKRG HHCCCHHHHHHHHCC	26.12	-
525	Phosphorylation	EKRGGEESLETEKTQ HHCCCHHHCCCCCCC	27.48	24719451
528	Phosphorylation	GGEESLETEKTQGTE CCHHHCCCCCCCCCC	48.34	28857561
531	Phosphorylation	ESLETEKTQGTEGDL HHCCCCCCCCCCCCC	26.46	28857561
534	Phosphorylation	ETEKTQGTEGDLNLE CCCCCCCCCCCCCHH	27.29	28857561
544	Phosphorylation	DLNLEQGSREGSESQ CCCHHHCCCCCCHHH	27.18	19664994
548	Phosphorylation	EQGSREGSESQAEEM HHCCCCCCHHHHHHH	29.35	26657352
550	Phosphorylation	GSREGSESQAEEMNE CCCCCCHHHHHHHHH	36.07	25849741
566	Phosphorylation	GPPLEANTETRPEKE CCCCCCCCCCCCCCC	45.86	23186163
568	Phosphorylation	PLEANTETRPEKEGP CCCCCCCCCCCCCCC	49.86	23186163
606	Phosphorylation	QGPLGDATPLLAETP CCCCCCCCCCCCCCC	21.14	24275569
654	Phosphorylation	QPEPSAPTEGEEASG CCCCCCCCCCCCCCC	57.23	24275569
660	Phosphorylation	PTEGEEASGPKQKTC CCCCCCCCCCCCCCC	59.93	28857561
667	S-palmitoylation	SGPKQKTCQCCAVM- CCCCCCCCCCCCCC-	3.62	-
669	S-palmitoylation	PKQKTCQCCAVM--- CCCCCCCCCCCC---	1.42	-
670	Methylation	KQKTCQCCAVM---- CCCCCCCCCCC----	1.00	-
670	Farnesylation	KQKTCQCCAVM---- CCCCCCCCCCC----	1.00	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PALM3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
667	C	Palmitoylation	Palmitoylated on Cys-667 and Cys-669 and prenylated on Cys-670; which is required for membrane association.	-
669	C	Palmitoylation	Palmitoylated on Cys-667 and Cys-669 and prenylated on Cys-670; which is required for membrane association.	-
670	C	Palmitoylation	Palmitoylated on Cys-667 and Cys-669 and prenylated on Cys-670; which is required for membrane association.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PALM3_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PALM3_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.