ACBD6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACBD6_HUMAN
• UniProt AC: Q9BR61
• Protein Name: Acyl-CoA-binding domain-containing protein 6
• Gene Name: ACBD6
• Organism: Homo sapiens (Human).
• Sequence Length: 282
• Subcellular Localization: Cytoplasm .
• Protein Description: Binds long-chain acyl-coenzyme A molecules with a strong preference for unsaturated C18:1-CoA, lower affinity for unsaturated C20:4-CoA, and very weak affinity for saturated C16:0-CoA. Does not bind fatty acids..
• Protein Sequence: MASSFLPAGAITGDSGGELSSGDDSGEVEFPHSPEIEETSCLAELFEKAAAHLQGLIQVASREQLLYLYARYKQVKVGNCNTPKPSFFDFEGKQKWEAWKALGDSSPSQAMQEYIAVVKKLDPGWNPQIPEKKGKEANTGFGGPVISSLYHEETIREEDKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVLQRHTTGKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASSFLPAGA -----CCCCCCCCCC	21.96	21406692
4	Phosphorylation	----MASSFLPAGAI ----CCCCCCCCCCE	22.67	21406692
12	Phosphorylation	FLPAGAITGDSGGEL CCCCCCEECCCCCCC	34.11	21406692
15	Phosphorylation	AGAITGDSGGELSSG CCCEECCCCCCCCCC	50.47	21406692
20	Phosphorylation	GDSGGELSSGDDSGE CCCCCCCCCCCCCCC	28.15	21406692
21	Phosphorylation	DSGGELSSGDDSGEV CCCCCCCCCCCCCCE	59.89	21406692
25	Phosphorylation	ELSSGDDSGEVEFPH CCCCCCCCCCEECCC	41.41	21406692
33	Phosphorylation	GEVEFPHSPEIEETS CCEECCCCCCCCCCH	25.19	21406692
39	Phosphorylation	HSPEIEETSCLAELF CCCCCCCCHHHHHHH	16.38	21406692
40	Phosphorylation	SPEIEETSCLAELFE CCCCCCCHHHHHHHH	15.48	21406692
69	Phosphorylation	REQLLYLYARYKQVK HHHHHHHHHHHCCCE	3.88	25147952
72	Phosphorylation	LLYLYARYKQVKVGN HHHHHHHHCCCEECC	9.52	72840213
76	Ubiquitination	YARYKQVKVGNCNTP HHHHCCCEECCCCCC	41.76	-
82	Phosphorylation	VKVGNCNTPKPSFFD CEECCCCCCCCCCCC	34.58	25159151
84	Ubiquitination	VGNCNTPKPSFFDFE ECCCCCCCCCCCCCC	51.78	-
84	Acetylation	VGNCNTPKPSFFDFE ECCCCCCCCCCCCCC	51.78	26051181
86	Phosphorylation	NCNTPKPSFFDFEGK CCCCCCCCCCCCCCH	44.67	72840219
93	Ubiquitination	SFFDFEGKQKWEAWK CCCCCCCHHHHHHHH	41.32	-
95	Acetylation	FDFEGKQKWEAWKAL CCCCCHHHHHHHHHH	50.95	25953088
95	Ubiquitination	FDFEGKQKWEAWKAL CCCCCHHHHHHHHHH	50.95	-
100	Ubiquitination	KQKWEAWKALGDSSP HHHHHHHHHHCCCCH	40.56	-
105	Phosphorylation	AWKALGDSSPSQAMQ HHHHHCCCCHHHHHH	42.21	30278072
106	Phosphorylation	WKALGDSSPSQAMQE HHHHCCCCHHHHHHH	33.05	30278072
108	Phosphorylation	ALGDSSPSQAMQEYI HHCCCCHHHHHHHHH	32.30	25159151
111	Sulfoxidation	DSSPSQAMQEYIAVV CCCHHHHHHHHHHHH	2.11	30846556
114	Phosphorylation	PSQAMQEYIAVVKKL HHHHHHHHHHHHHHC	4.18	22199227
119	Ubiquitination	QEYIAVVKKLDPGWN HHHHHHHHHCCCCCC	40.81	-
120	Ubiquitination	EYIAVVKKLDPGWNP HHHHHHHHCCCCCCC	46.65	-
120	Sumoylation	EYIAVVKKLDPGWNP HHHHHHHHCCCCCCC	46.65	-
120	Sumoylation	EYIAVVKKLDPGWNP HHHHHHHHCCCCCCC	46.65	-
132	Ubiquitination	WNPQIPEKKGKEANT CCCCCCHHCCCCCCC	62.56	-
135	Ubiquitination	QIPEKKGKEANTGFG CCCHHCCCCCCCCCC	63.63	-
150	Phosphorylation	GPVISSLYHEETIRE CCHHHHHHCHHHCCH	14.77	132401
154	Phosphorylation	SSLYHEETIREEDKN HHHHCHHHCCHHHHC	23.50	28555341
160	Ubiquitination	ETIREEDKNIFDYCR HHCCHHHHCHHHHHH	56.04	-
175	Phosphorylation	ENNIDHITKAIKSKN HCCHHHHHHHHHHCC	15.82	29083192
176	Ubiquitination	NNIDHITKAIKSKNV CCHHHHHHHHHHCCC	47.73	21890473
179	Ubiquitination	DHITKAIKSKNVDVN HHHHHHHHHCCCCEE	61.30	21890473
180	Phosphorylation	HITKAIKSKNVDVNV HHHHHHHHCCCCEEE	24.29	29083192
181	Ubiquitination	ITKAIKSKNVDVNVK HHHHHHHCCCCEEEE	56.86	-
188	Sumoylation	KNVDVNVKDEEGRAL CCCCEEEECHHHHHH	54.97	-
188	Ubiquitination	KNVDVNVKDEEGRAL CCCCEEEECHHHHHH	54.97	-
188	Sumoylation	KNVDVNVKDEEGRAL CCCCEEEECHHHHHH	54.97	-
268	Ubiquitination	PEEVTGCKTVSLVLQ CHHHCCCCCHHHHHH	53.99	-
269	Phosphorylation	EEVTGCKTVSLVLQR HHHCCCCCHHHHHHH	21.28	28555341
271	Phosphorylation	VTGCKTVSLVLQRHT HCCCCCHHHHHHHCC	20.28	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACBD6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACBD6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACBD6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.