CRBB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRBB2_HUMAN
• UniProt AC: P43320
• Protein Name: Beta-crystallin B2
• Gene Name: CRYBB2
• Organism: Homo sapiens (Human).
• Sequence Length: 205
• Protein Description: Crystallins are the dominant structural components of the vertebrate eye lens..
• Protein Sequence: MASDHQTQAGKPQSLNPKIIIFEQENFQGHSHELNGPCPNLKETGVEKAGSVLVQAGPWVGYEQANCKGEQFVFEKGEYPRWDSWTSSRRTDSLSSLRPIKVDSQEHKIILYENPNFTGKKMEIIDDDVPSFHAHGYQEKVSSVRVQSGTWVGYQYPGYRGLQYLLEKGDYKDSSDFGAPHPQVQSVRRIRDMQWHQRGAFHPSN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASDHQTQA ------CCCCCCCCC	24.54	8443605
3	Phosphorylation	-----MASDHQTQAG -----CCCCCCCCCC	34.04	29978859
7	Phosphorylation	-MASDHQTQAGKPQS -CCCCCCCCCCCCCC	19.57	29978859
11	Methylation	DHQTQAGKPQSLNPK CCCCCCCCCCCCCCE	42.79	17022627
14	Phosphorylation	TQAGKPQSLNPKIII CCCCCCCCCCCEEEE	38.34	29978859
42	Methylation	NGPCPNLKETGVEKA CCCCCCHHHHCCEEC	60.93	23161681
68	Methylation	GYEQANCKGEQFVFE CCEECCCCCCEEEEE	66.35	12060738
76	Acetylation	GEQFVFEKGEYPRWD CCEEEEECCCCCCCC	45.65	12060738
91	Phosphorylation	SWTSSRRTDSLSSLR CCCCCCCCCCCHHCC	28.91	-
93	Phosphorylation	TSSRRTDSLSSLRPI CCCCCCCCCHHCCCE	29.54	22167270
95	Phosphorylation	SRRTDSLSSLRPIKV CCCCCCCHHCCCEEE	31.14	22167270
96	Phosphorylation	RRTDSLSSLRPIKVD CCCCCCHHCCCEEEC	33.42	22167270
104	Phosphorylation	LRPIKVDSQEHKIIL CCCEEECCCCCEEEE	40.22	-
118	Phosphorylation	LYENPNFTGKKMEII EEECCCCCCCEEEEE	55.52	22817900
120	Methylation	ENPNFTGKKMEIIDD ECCCCCCCEEEEECC	45.98	12060738
121	Methylation	NPNFTGKKMEIIDDD CCCCCCCEEEEECCC	43.01	23161681
121	Acetylation	NPNFTGKKMEIIDDD CCCCCCCEEEEECCC	43.01	12060738
174	Phosphorylation	EKGDYKDSSDFGAPH HCCCCCCCCCCCCCC	27.88	29083192
175	Phosphorylation	KGDYKDSSDFGAPHP CCCCCCCCCCCCCCH	47.28	29083192

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRBB2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRBB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRBB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRYAA_HUMAN	CRYAA	physical	11700327
CRYAB_HUMAN	CRYAB	physical	11700327
CRGC_HUMAN	CRYGC	physical	11700327
CRBB2_HUMAN	CRYBB2	physical	11700327
HSPB1_HUMAN	HSPB1	physical	11700327
CRYAB_HUMAN	CRYAB	physical	16274233

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 601547: Cataract 3, multiple types (CTRCT3)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Shotgun identification of protein modifications from proteincomplexes and lens tissue.";
MacCoss M.J., McDonald W.H., Saraf A., Sadygov R., Clark J.M.,Tasto J.J., Gould K.L., Wolters D., Washburn M., Weiss A., Clark J.I.,Yates J.R. III;
Proc. Natl. Acad. Sci. U.S.A. 99:7900-7905(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-118, ACETYLATION ATLYS-76 AND LYS-121, METHYLATION AT LYS-42; LYS-68 AND LYS-121,SUSCEPTIBILITY TO OXIDATION, AND MASS SPECTROMETRY.
PubMed: 12060738

Methylation

"Shotgun identification of protein modifications from proteincomplexes and lens tissue.";
MacCoss M.J., McDonald W.H., Saraf A., Sadygov R., Clark J.M.,Tasto J.J., Gould K.L., Wolters D., Washburn M., Weiss A., Clark J.I.,Yates J.R. III;
Proc. Natl. Acad. Sci. U.S.A. 99:7900-7905(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-118, ACETYLATION ATLYS-76 AND LYS-121, METHYLATION AT LYS-42; LYS-68 AND LYS-121,SUSCEPTIBILITY TO OXIDATION, AND MASS SPECTROMETRY.
PubMed: 12060738

Phosphorylation

"Shotgun identification of protein modifications from proteincomplexes and lens tissue.";
MacCoss M.J., McDonald W.H., Saraf A., Sadygov R., Clark J.M.,Tasto J.J., Gould K.L., Wolters D., Washburn M., Weiss A., Clark J.I.,Yates J.R. III;
Proc. Natl. Acad. Sci. U.S.A. 99:7900-7905(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-118, ACETYLATION ATLYS-76 AND LYS-121, METHYLATION AT LYS-42; LYS-68 AND LYS-121,SUSCEPTIBILITY TO OXIDATION, AND MASS SPECTROMETRY.
PubMed: 12060738