CRGC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRGC_HUMAN
• UniProt AC: P07315
• Protein Name: Gamma-crystallin C
• Gene Name: CRYGC
• Organism: Homo sapiens (Human).
• Sequence Length: 174
• Protein Description: Crystallins are the dominant structural components of the vertebrate eye lens..
• Protein Sequence: MGKITFYEDRAFQGRSYETTTDCPNLQPYFSRCNSIRVESGCWMLYERPNYQGQQYLLRRGEYPDYQQWMGLSDSIRSCCLIPQTVSHRLRLYEREDHKGLMMELSEDCPSIQDRFHLSEIRSLHVLEGCWVLYELPNYRGRQYLLRPQEYRRCQDWGAMDAKAGSLRRVVDLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MGKITFYEDRAF ---CCCEEEEECCCC	24.53	25404012
7	Phosphorylation	-MGKITFYEDRAFQG -CCCEEEEECCCCCC	14.31	25404012
16	Phosphorylation	DRAFQGRSYETTTDC CCCCCCCCEEECCCC	33.86	24043423
17	Phosphorylation	RAFQGRSYETTTDCP CCCCCCCEEECCCCC	18.88	24043423
19	Phosphorylation	FQGRSYETTTDCPNL CCCCCEEECCCCCCC	27.11	24043423
20	Phosphorylation	QGRSYETTTDCPNLQ CCCCEEECCCCCCCH	14.54	24043423
21	Phosphorylation	GRSYETTTDCPNLQP CCCEEECCCCCCCHH	42.92	24043423
23	Methylation	SYETTTDCPNLQPYF CEEECCCCCCCHHHH	1.95	12876325
29	Phosphorylation	DCPNLQPYFSRCNSI CCCCCHHHHHHCCCE	10.96	24043423
31	Phosphorylation	PNLQPYFSRCNSIRV CCCHHHHHHCCCEEE	30.04	24043423
63	Phosphorylation	YLLRRGEYPDYQQWM HHHHCCCCCCHHHHH	12.29	22817900
66	Phosphorylation	RRGEYPDYQQWMGLS HCCCCCCHHHHHCCC	9.71	22817900
80	Methylation	SDSIRSCCLIPQTVS CHHHHHHCCCCHHHH	3.99	-
119	Phosphorylation	IQDRFHLSEIRSLHV HHHHHCHHHHHHHHH	23.54	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRGC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRGC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRGC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRYAA_HUMAN	CRYAA	physical	11700327
CRYAB_HUMAN	CRYAB	physical	11700327
CRBB2_HUMAN	CRYBB2	physical	11700327
CRGC_HUMAN	CRYGC	physical	11700327
CRGC_HUMAN	CRYGC	physical	12601044
CRYAA_HUMAN	CRYAA	physical	12601044
CRYAB_HUMAN	CRYAB	physical	12601044
CRBB2_HUMAN	CRYBB2	physical	12601044
CRGD_HUMAN	CRYGD	physical	12601044
HSPB1_HUMAN	HSPB1	physical	12601044
HSPB2_HUMAN	HSPB2	physical	12601044
CRGB_HUMAN	CRYGB	physical	26186194
CRGB_HUMAN	CRYGB	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 604307: Cataract 2, multiple types (CTRCT2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Methylation

"Methylation and carbamylation of human gamma-crystallins.";
Lapko V.N., Smith D.L., Smith J.B.;
Protein Sci. 12:1762-1774(2003).
Cited for: METHYLATION AT CYS-23, AND MASS SPECTROMETRY.
PubMed: 12876325

Phosphorylation

"Shotgun identification of protein modifications from proteincomplexes and lens tissue.";
MacCoss M.J., McDonald W.H., Saraf A., Sadygov R., Clark J.M.,Tasto J.J., Gould K.L., Wolters D., Washburn M., Weiss A., Clark J.I.,Yates J.R. III;
Proc. Natl. Acad. Sci. U.S.A. 99:7900-7905(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-63 AND TYR-66,SUSCEPTIBILITY TO OXIDATION, AND MASS SPECTROMETRY.
PubMed: 12060738