CRGD_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRGD_HUMAN
• UniProt AC: P07320
• Protein Name: Gamma-crystallin D
• Gene Name: CRYGD
• Organism: Homo sapiens (Human).
• Sequence Length: 174
• Protein Description: Crystallins are the dominant structural components of the vertebrate eye lens..
• Protein Sequence: MGKITLYEDRGFQGRHYECSSDHPNLQPYLSRCNSARVDSGCWMLYEQPNYSGLQYFLRRGDYADHQQWMGLSDSVRSCRLIPHSGSHRIRLYEREDYRGQMIEFTEDCSCLQDRFRFNEIHSLNVLEGSWVLYELSNYRGRQYLLMPGDYRRYQDWGATNARVGSLRRVIDFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MGKITLYEDRGFQG -CCCEEEECCCCCCC	13.72	-
10	Methylation	KITLYEDRGFQGRHY CEEEECCCCCCCCCE	35.57	-
111	Methylation	EFTEDCSCLQDRFRF EECCCCCHHHHHHCC	5.07	-
166	Phosphorylation	ATNARVGSLRRVIDF CCCCCCCCEEEEECC	18.82	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRGD_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRGD_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRGD_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CRYAB_HUMAN	CRYAB	physical	21173272
CRYAB_HUMAN	CRYAB	physical	16274233
CRYAB_HUMAN	CRYAB	physical	22655036
CRYAA_HUMAN	CRYAA	physical	22655036
CRGD_HUMAN	CRYGD	physical	22655036

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 115700: Cataract 4, multiple types (CTRCT4)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.