CRGB_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRGB_HUMAN
• UniProt AC: P07316
• Protein Name: Gamma-crystallin B
• Gene Name: CRYGB
• Organism: Homo sapiens (Human).
• Sequence Length: 175
• Protein Description: Crystallins are the dominant structural components of the vertebrate eye lens..
• Protein Sequence: MGKITFYEDRAFQGRSYECTTDCPNLQPYFSRCNSIRVESGCWMIYERPNYQGHQYFLRRGEYPDYQQWMGLSDSIRSCCLIPPHSGAYRMKIYDRDELRGQMSELTDDCISVQDRFHLTEIHSLNVLEGSWILYEMPNYRGRQYLLRPGEYRRFLDWGAPNAKVGSLRRVMDLY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MGKITFYEDRAF ---CCCEEEEECCCC	24.53	25404012
7	Phosphorylation	-MGKITFYEDRAFQG -CCCEEEEECCCCCC	14.31	25404012
23	Methylation	SYECTTDCPNLQPYF EEEECCCCCCCHHHH	1.95	12876325
63	Phosphorylation	YFLRRGEYPDYQQWM CCCCCCCCCCHHHHC	12.29	21082442
66	Phosphorylation	RRGEYPDYQQWMGLS CCCCCCCHHHHCCCC	9.71	21082442
79	Methylation	LSDSIRSCCLIPPHS CCCCHHHCCCCCCCC	1.25	-
80	Methylation	SDSIRSCCLIPPHSG CCCHHHCCCCCCCCC	3.99	12876325

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRGB_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRGB_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRGB_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CRGB_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 615188: Cataract 39, multiple types (CTRCT39)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Shotgun identification of protein modifications from proteincomplexes and lens tissue.";
MacCoss M.J., McDonald W.H., Saraf A., Sadygov R., Clark J.M.,Tasto J.J., Gould K.L., Wolters D., Washburn M., Weiss A., Clark J.I.,Yates J.R. III;
Proc. Natl. Acad. Sci. U.S.A. 99:7900-7905(2002).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-63 AND TYR-66,SUSCEPTIBILITY TO OXIDATION, AND MASS SPECTROMETRY.
PubMed: 12060738