LCE3A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LCE3A_HUMAN
• UniProt AC: Q5TA76
• Protein Name: Late cornified envelope protein 3A {ECO:0000303|PubMed:15854049}
• Gene Name: LCE3A {ECO:0000303|PubMed:15854049, ECO:0000312|HGNC:HGNC:29461}
• Organism: Homo sapiens (Human).
• Sequence Length: 89
• Protein Description: A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. [PubMed: 28634035]
• Protein Sequence: MSCQQNQQQCQPPPKCPAKSPAQCLPPASSSCAPSSGGCGPSSERSCCLSHHRCRRSHRCRCQSSNSCDRGSGQQGGSSSCGHSSAGCC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	PPKCPAKSPAQCLPP CCCCCCCCHHHCCCC	27.81	22817900
31	Phosphorylation	CLPPASSSCAPSSGG CCCCCCCCCCCCCCC	16.29	22817900
42	Phosphorylation	SSGGCGPSSERSCCL CCCCCCCCHHHCHHH	30.07	22817900
78	Phosphorylation	GSGQQGGSSSCGHSS CCCCCCCCCCCCCCC	26.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LCE3A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LCE3A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LCE3A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LCE3A_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.