TXIP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TXIP1_HUMAN
• UniProt AC: Q2TAA8
• Protein Name: Translin-associated factor X-interacting protein 1
• Gene Name: TSNAXIP1 {ECO:0000312|EMBL:AAI11019.1}
• Organism: Homo sapiens (Human).
• Sequence Length: 658
• Subcellular Localization: Cytoplasm, perinuclear region .
• Protein Description: Possible role in spermatogenesis..
• Protein Sequence: MGGHLSPWPTYTSGQTILQNRKPCSDDYRKRVGSCQQHPFRTAKPQYLEELENYLRKELLLLDLGTDSTQELRLQPYREIFEFFIEDFKTYKPLLSSIKNAYEGMLAHQREKIRALEPLKAKLVTVNEDCNERILAMRAEEKYEISLLKKEKMNLLKLIDKKNEEKISLQSEVTKLRKNLAEEYLHYLSERDACKILIADLNELRYQREDMSLAQSPGIWGEDPVKLTLALKMTRQDLTRTQMELNNMKANFGDVVPRRDFEMQEKTNKDLQEQLDTLRASYEEVRKEHEILMQLHMSTLKERDQFFSELQEIQRTSTPRPDWTKCKDVVAGGPERWQMLAEGKNSDQLVDVLLEEIGSGLLREKDFFPGLGYGEAIPAFLRFDGLVENKKPSKKDVVNLLKDAWKERLAEEQKETFPDFFFNFLEHRFGPSDAMAWAYTIFENIKIFHSNEVMSQFYAVLMGKRSENVYVTQKETVAQLLKEMTNADSQNEGLLTMEQFNTVLKSTFPLKTEEQIQELMEAGGWHPSSSNADLLNYRSLFMEDEEGQSEPFVQKLWEQYMDEKDEYLQQLKQELGIELHEEVTLPKLRGGLMTIDPSLDKQTVNTYMSQAFQLPESEMPEEGDEKEEAVVEILQTALERLQVIDIRRVGPREPEPAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MGGHLSPWPTYTS --CCCCCCCCCCCCC	21.17	24043423
10	Phosphorylation	GHLSPWPTYTSGQTI CCCCCCCCCCCCCCH	35.25	24043423
11	Phosphorylation	HLSPWPTYTSGQTIL CCCCCCCCCCCCCHH	8.53	24043423
12	Phosphorylation	LSPWPTYTSGQTILQ CCCCCCCCCCCCHHH	28.94	24043423
13	Phosphorylation	SPWPTYTSGQTILQN CCCCCCCCCCCHHHC	20.63	24043423
16	Phosphorylation	PTYTSGQTILQNRKP CCCCCCCCHHHCCCC	27.47	24043423
47	Phosphorylation	FRTAKPQYLEELENY CCCCCHHHHHHHHHH	25.30	24114839
54	Phosphorylation	YLEELENYLRKELLL HHHHHHHHHHHHHHH	9.86	24114839
66	Phosphorylation	LLLLDLGTDSTQELR HHHHCCCCCCCHHHH	33.79	25693802
68	Phosphorylation	LLDLGTDSTQELRLQ HHCCCCCCCHHHHCC	31.65	25693802
69	Phosphorylation	LDLGTDSTQELRLQP HCCCCCCCHHHHCCC	28.95	25693802
96	Phosphorylation	KTYKPLLSSIKNAYE HHHHHHHHHHHHHHH	37.39	24719451
146	Phosphorylation	AEEKYEISLLKKEKM HHHHHHHHHHHHHHC	18.73	24719451
239	Phosphorylation	KMTRQDLTRTQMELN HHHHHHHHHHHHHHH	39.70	29978859
241	Phosphorylation	TRQDLTRTQMELNNM HHHHHHHHHHHHHHH	27.34	29978859
277	Phosphorylation	DLQEQLDTLRASYEE HHHHHHHHHHHHHHH	27.08	24114839
316	Phosphorylation	ELQEIQRTSTPRPDW HHHHHHHCCCCCCCC	22.15	30622161
317	Phosphorylation	LQEIQRTSTPRPDWT HHHHHHCCCCCCCCC	38.31	30622161
318	Phosphorylation	QEIQRTSTPRPDWTK HHHHHCCCCCCCCCH	23.78	30622161
466	Phosphorylation	AVLMGKRSENVYVTQ HHHCCCCCCCEEECC	36.69	30622161
470	Phosphorylation	GKRSENVYVTQKETV CCCCCCEEECCHHHH	14.90	30622161
472	Phosphorylation	RSENVYVTQKETVAQ CCCCEEECCHHHHHH	19.08	30622161
594	Phosphorylation	KLRGGLMTIDPSLDK CCCCCEEECCCCCCH	27.54	-
598	Phosphorylation	GLMTIDPSLDKQTVN CEEECCCCCCHHHHH	45.51	-
636	Phosphorylation	AVVEILQTALERLQV HHHHHHHHHHHHCCC	29.75	30631047

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TXIP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TXIP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TXIP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
UB2L3_HUMAN	UBE2L3	physical	22939629
PIBF1_HUMAN	PIBF1	physical	28514442
CC186_HUMAN	CCDC186	physical	28514442
DPP8_HUMAN	DPP8	physical	28514442
FBXW5_HUMAN	FBXW5	physical	28514442
USO1_HUMAN	USO1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.