CISY_PIG - dbPTM
CISY_PIG - PTM Information in dbPTM
Basic Information of Protein
UniProt ID CISY_PIG
UniProt AC P00889
Protein Name Citrate synthase, mitochondrial
Gene Name CS
Organism Sus scrofa (Pig).
Sequence Length 464
Subcellular Localization Mitochondrion matrix.
Protein Description
Protein Sequence MALLTAAARLFGAKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGNTVVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGYSIPECQKMLPKAKGGEEPLPEGLFWLLVTGQIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAITALNSESNFARAYAEGIHRTKYWELIYEDCMDLIAKLPCVAAKIYRNLYREGSSIGAIDSKLDWSHNFTNMLGYTDAQFTELMRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPHDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTDGLIKLVDSK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
76SuccinylationYGGMRGMKGLVYETS
CCCCCCCCCEEEEEE		52.49-
76SuccinylationYGGMRGMKGLVYETS
CCCCCCCCCEEEEEE		52.4922076378
76AcetylationYGGMRGMKGLVYETS
CCCCCCCCCEEEEEE		52.49-
103SuccinylationYSIPECQKMLPKAKG
CCCHHHHHHCCCCCC		54.80-
103SuccinylationYSIPECQKMLPKAKG
CCCHHHHHHCCCCCC		54.80-
193SuccinylationAEGIHRTKYWELIYE
HCCCHHHHHHHHHHH		48.61-
193SuccinylationAEGIHRTKYWELIYE
HCCCHHHHHHHHHHH		48.61-
226PhosphorylationNLYREGSSIGAIDSK
HHHHCCCCCCCCCCC		35.58-
321SuccinylationQLQKEVGKDVSDEKL
HHHHHHCCCCCHHHH		61.20-
321AcetylationQLQKEVGKDVSDEKL
HHHHHHCCCCCHHHH		61.20-
321SuccinylationQLQKEVGKDVSDEKL
HHHHHHCCCCCHHHH		61.20-
327AcetylationGKDVSDEKLRDYIWN
CCCCCHHHHHHHHHH		54.54-
327SuccinylationGKDVSDEKLRDYIWN
CCCCCHHHHHHHHHH		54.54-
327SuccinylationGKDVSDEKLRDYIWN
CCCCCHHHHHHHHHH		54.54-
375AcetylationLPHDPMFKLVAQLYK
CCCCHHHHHHHHHHH		35.48-
375SuccinylationLPHDPMFKLVAQLYK
CCCCHHHHHHHHHHH		35.48-
375SuccinylationLPHDPMFKLVAQLYK
CCCCHHHHHHHHHHH		35.48-
382AcetylationKLVAQLYKIVPNVLL
HHHHHHHHHHHHHHH		45.91-
393AcetylationNVLLEQGKAKNPWPN
HHHHHCCCCCCCCCC		56.75-
393SuccinylationNVLLEQGKAKNPWPN
HHHHHCCCCCCCCCC		56.75-
393SuccinylationNVLLEQGKAKNPWPN
HHHHHCCCCCCCCCC		56.75-
395"N6,N6,N6-trimethyllysine"LLEQGKAKNPWPNVD
HHHCCCCCCCCCCCC		68.01-
395MethylationLLEQGKAKNPWPNVD
HHHCCCCCCCCCCCC		68.017093227
450SuccinylationGFPLERPKSMSTDGL
CCCCCCCCCCCCCCC		66.08-
450SuccinylationGFPLERPKSMSTDGL
CCCCCCCCCCCCCCC		66.08-
459SuccinylationMSTDGLIKLVDSK--
CCCCCCEEHHCCC--		47.72-
459AcetylationMSTDGLIKLVDSK--
CCCCCCEEHHCCC--		47.72-
459SuccinylationMSTDGLIKLVDSK--
CCCCCCEEHHCCC--		47.72-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of CISY_PIG !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of CISY_PIG !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of CISY_PIG !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of CISY_PIG !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of CISY_PIG

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Related Literatures of Post-Translational Modification
Methylation
ReferencePubMed
"Complete amino acid sequence of porcine heart citrate synthase.";
Bloxham D.P., Parmelee D.C., Kumar S., Walsh K.A., Titani K.;
Biochemistry 21:2028-2036(1982).
Cited for: PROTEIN SEQUENCE OF 28-464.

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