| UniProt ID | BICL1_HUMAN | |
|---|---|---|
| UniProt AC | Q6ZP65 | |
| Protein Name | BICD family-like cargo adapter 1 | |
| Gene Name | BICDL1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 573 | |
| Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Localizes around the centrosome.. | |
| Protein Description | Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis (By similarity).. | |
| Protein Sequence | MSAFCLGLVGRASAPAEPDSACCMELPAAAGDAVRSPAAAAALIFPGGSGELELALEEELALLAAGERPSDPGEHPQAEPGSLAEGAGPQPPPSQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELESDVKQLQDELERQQIHLREADREKSRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALREDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSCRQLQVKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNELKRLIQSIVDGMEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCRMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKERSQPAAALCRGHSAGRGDEPSIAEGKRLFSFFRKI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 131 | Phosphorylation | NQDMSRQYEQMHKEL CHHHHHHHHHHHHHH | 18083107 | ||
| 139 | Phosphorylation | EQMHKELTDKLEHLE HHHHHHHHHHHHHHH | 26503514 | ||
| 153 | Dimethylation | EQEKHELRRRFENRE HHHHHHHHHHHHCCC | - | ||
| 154 | Dimethylation | QEKHELRRRFENREG HHHHHHHHHHHCCCC | - | ||
| 217 | Phosphorylation | LDQLSRASEVERQLS HHHHHHHHHHHHHHH | 22210691 | ||
| 224 | Phosphorylation | SEVERQLSMQVHALR HHHHHHHHHHHHHHH | 22210691 | ||
| 402 | Phosphorylation | DSSMDESSETSSAKD CCCCCCCCCCCCCCC | 23532336 | ||
| 405 | Phosphorylation | MDESSETSSAKDVPA CCCCCCCCCCCCCCH | - | ||
| 406 | Phosphorylation | DESSETSSAKDVPAG CCCCCCCCCCCCCHH | - | ||
| 428 | Phosphorylation | ELKRLIQSIVDGMEP HHHHHHHHHHCCCCC | 24043423 | ||
| 436 | Phosphorylation | IVDGMEPTVTLLSVE HHCCCCCCEEEEEEE | 24043423 | ||
| 438 | Phosphorylation | DGMEPTVTLLSVEMT CCCCCCEEEEEEEHH | 24043423 | ||
| 441 | Phosphorylation | EPTVTLLSVEMTALK CCCEEEEEEEHHHHH | 24043423 | ||
| 445 | Phosphorylation | TLLSVEMTALKEERD EEEEEEHHHHHHHHH | 24043423 | ||
| 537 | Acetylation | QLMDTHLKERSQPAA HHHHHHHHHCCCHHH | 19826663 | ||
| 551 | Phosphorylation | AALCRGHSAGRGDEP HHHHCCCCCCCCCCC | 26657352 | ||
| 568 | Phosphorylation | AEGKRLFSFFRKI-- HHHHHHHHHHHCC-- | 24719451 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of BICL1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of BICL1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of BICL1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of BICL1_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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