RSPH3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RSPH3_HUMAN
• UniProt AC: Q86UC2
• Protein Name: Radial spoke head protein 3 homolog
• Gene Name: RSPH3
• Organism: Homo sapiens (Human).
• Sequence Length: 560
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme . Cell projection, cilium .
• Protein Description: Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia..
• Protein Sequence: MTVKPAKAASLARNLAKRRRTYLGGAAGRSQEPEVPCAAVLPGKPGDRNCPEFPPPDRTLGCWATDAAPAAGLCGAGSEPSIAPTSCAGNLPSRPPPLLSPLLASRNPCPWHYLHLSGSHNTLAPTCFKAKLHRKRGSQPPDMASALTDRTSRAPSTYTYTSRPRALPCQRSRYRDSLTQPDEEPMHYGNIMYDRRVIRGNTYALQTGPLLGRPDSLELQRQREARKRALARKQAQEQLRPQTPEPVEGRKHVDVQTELYLEEIADRIIEVDMECQTDAFLDRPPTPLFIPAKTGKDVATQILEGELFDFDLEVKPVLEVLVGKTIEQSLLEVMEEEELANLRASQREYEELRNSERAEVQRLEEQERRHREEKERRKKQQWEIMHKHNETSQKIAARAFAQRYLADLLPSVFGSLRDSGYFYDPIERDIEIGFLPWLMNEVEKTMEYSMVGRTVLDMLIREVVEKRLCMYEHGEDTHQSPEPEDEPGGPGAMTESLEASEFLEQSMSQTRELLLDGGYLQRTTYDRRSSQERKFMEERELLGQDEETAMRKSLGEEELS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTVKPAKAA ------CCCCHHHHH	36.92	22617229
21	Phosphorylation	NLAKRRRTYLGGAAG HHHHHHHHHHCCCCC	22.68	-
151	Phosphorylation	ASALTDRTSRAPSTY HHHHCCCCCCCCCCC	25.94	-
172	Phosphorylation	RALPCQRSRYRDSLT CCCCCCCHHHHHCCC	14.05	-
174	Phosphorylation	LPCQRSRYRDSLTQP CCCCCHHHHHCCCCC	21.73	25693802
177	Phosphorylation	QRSRYRDSLTQPDEE CCHHHHHCCCCCCCC	25.07	25693802
179	Phosphorylation	SRYRDSLTQPDEEPM HHHHHCCCCCCCCCC	41.84	25693802
188	Phosphorylation	PDEEPMHYGNIMYDR CCCCCCCCCCEEEEC	12.96	25693802
193	Phosphorylation	MHYGNIMYDRRVIRG CCCCCEEEECEEEEC	11.51	25693802
207	Phosphorylation	GNTYALQTGPLLGRP CCCEEECCCCCCCCC	41.43	25693802
216	Phosphorylation	PLLGRPDSLELQRQR CCCCCCCHHHHHHHH	26.82	25693802
227	Acetylation	QRQREARKRALARKQ HHHHHHHHHHHHHHH	49.42	61287
233	Acetylation	RKRALARKQAQEQLR HHHHHHHHHHHHHHC	44.36	90629
233	Ubiquitination	RKRALARKQAQEQLR HHHHHHHHHHHHHHC	44.36	29967540
243	Phosphorylation	QEQLRPQTPEPVEGR HHHHCCCCCCCCCCC	32.10	27966365
286	Phosphorylation	AFLDRPPTPLFIPAK CCCCCCCCCCEEECC	34.99	14702039
298 (in isoform 2)	Ubiquitination	-	7.66	21906983
391	Phosphorylation	IMHKHNETSQKIAAR HHHHCCHHHHHHHHH	41.60	-
392	Phosphorylation	MHKHNETSQKIAARA HHHCCHHHHHHHHHH	24.25	-
394 (in isoform 1)	Ubiquitination	-	33.80	21906983
394	Ubiquitination	KHNETSQKIAARAFA HCCHHHHHHHHHHHH	33.80	21906983
415	Phosphorylation	LLPSVFGSLRDSGYF HHHHHHHHHHCCCCC	14.57	25693802
454	Phosphorylation	EYSMVGRTVLDMLIR HHCHHHHHHHHHHHH	21.35	-
456 (in isoform 2)	Ubiquitination	-	2.95	21906983
530	Phosphorylation	TTYDRRSSQERKFME CCCCCCCHHHHHHHH	33.96	30278072
552	Ubiquitination	DEETAMRKSLGEEEL CHHHHHHHHHCHHHC	36.63	2190698
552 (in isoform 1)	Ubiquitination	-	36.63	21906983
553	Phosphorylation	EETAMRKSLGEEELS HHHHHHHHHCHHHCC	31.10	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
286	T	Phosphorylation	Kinase	MAPK1	P28482	Uniprot
286	T	Phosphorylation	Kinase	MAPK3	P27361	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RSPH3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RSPH3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.