BAT1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BAT1_HUMAN
• UniProt AC: P82251
• Protein Name: b(0,+)-type amino acid transporter 1
• Gene Name: SLC7A9
• Organism: Homo sapiens (Human).
• Sequence Length: 487
• Subcellular Localization: Apical cell membrane ; Multi-pass membrane protein .
• Protein Description: Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high-affinity reabsorption of cystine in the kidney tubule..
• Protein Sequence: MGDTGLRKRREDEKSIQSQEPKTTSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLATLGALCFAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLIVIKPTSFAIICLSFSEYVCAPFYVGCKPPQIVVKCLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAIIIISGLVLLAQGNTKNFDNSFEGAQLSVGAISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQSQAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVRRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRFTRKELERPIKVPVVIPVLMTLISVFLVLAPIISKPTWEYLYCVLFILSGLLFYFLFVHYKFGWAQKISKPITMHLQMLMEVVPPEEDPE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MGDTGLRKRRE ----CCCCHHHHHHH	32.17	29485707
15	Phosphorylation	KRREDEKSIQSQEPK HHHHCHHHHCCCCCC	24.66	28857561
18	Phosphorylation	EDEKSIQSQEPKTTS HCHHHHCCCCCCCCH	34.54	28857561
23	Phosphorylation	IQSQEPKTTSLQKEL HCCCCCCCCHHHHHH	32.12	22673903
24	Phosphorylation	QSQEPKTTSLQKELG CCCCCCCCHHHHHHH	33.30	22673903
25	Phosphorylation	SQEPKTTSLQKELGL CCCCCCCHHHHHHHH	33.75	22673903
169	Phosphorylation	ISTVNSLSVRLGSYV HHCHHHHHHHHHHHH	12.66	24719451
339	Ubiquitination	GREGHMLKVLSYISV CCCCHHHHHHHHHHH	33.29	-
342	Phosphorylation	GHMLKVLSYISVRRL CHHHHHHHHHHHCCC	24.33	-
345	Phosphorylation	LKVLSYISVRRLTPA HHHHHHHHHCCCCCC	11.01	-
470	Phosphorylation	QKISKPITMHLQMLM HHCCCCCHHHHHHHH	13.68	26552605

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BAT1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BAT1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BAT1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TGM2_HUMAN	TGM2	physical	21988832

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.