TMCO3_HUMAN - dbPTM
TMCO3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TMCO3_HUMAN
UniProt AC Q6UWJ1
Protein Name Transmembrane and coiled-coil domain-containing protein 3
Gene Name TMCO3
Organism Homo sapiens (Human).
Sequence Length 677
Subcellular Localization Membrane
Multi-pass membrane protein .
Protein Description Probable Na(+)/H(+) antiporter..
Protein Sequence MKVLGRSFFWVLFPVLPWAVQAVEHEEVAQRVIKLHRGRGVAAMQSRQWVRDSCRKLSGLLRQKNAVLNKLKTAIGAVEKDVGLSDEEKLFQVHTFEIFQKELNESENSVFQAVYGLQRALQGDYKDVVNMKESSRQRLEALREAAIKEETEYMELLAAEKHQVEALKNMQHQNQSLSMLDEILEDVRKAADRLEEEIEEHAFDDNKSVKGVNFEAVLRVEEEEANSKQNITKREVEDDLGLSMLIDSQNNQYILTKPRDSTIPRADHHFIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKVWKISLQGPCYMTLLMIAFGLLWGHLLRIKPTQSVFISTCLSLSSTPLVSRFLMGSARGDKEGDIDYSTVLLGMLVTQDVQLGLFMAVMPTLIQAGASASSSIVVEVLRILVLIGQILFSLAAVFLLCLVIKKYLIGPYYRKLHMESKGNKEILILGISAFIFLMLTVTELLDVSMELGCFLAGALVSSQGPVVTEEIATSIEPIRDFLAIVFFASIGLHVFPTFVAYELTVLVFLTLSVVVMKFLLAALVLSLILPRSSQYIKWIVSAGLAQVSEFSFVLGSRARRAGVISREVYLLILSVTTLSLLLAPVLWRAAITRCVPRPERRSSL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
64UbiquitinationLSGLLRQKNAVLNKL
HHHHHHHHHHHHHHH		40.20-
80UbiquitinationTAIGAVEKDVGLSDE
HHHHHHHHCCCCCCH		51.63-
85PhosphorylationVEKDVGLSDEEKLFQ
HHHCCCCCCHHHHHH		36.7326657352
132 (in isoform 1)Ubiquitination-49.6021906983
132 (in isoform 2)Ubiquitination-49.6021906983
132 (in isoform 3)Ubiquitination-49.6021906983
132UbiquitinationYKDVVNMKESSRQRL
HHHHCCCCHHHHHHH		49.6021906983
134PhosphorylationDVVNMKESSRQRLEA
HHCCCCHHHHHHHHH		25.8828348404
135PhosphorylationVVNMKESSRQRLEAL
HCCCCHHHHHHHHHH		33.2628348404
148 (in isoform 3)Ubiquitination-44.7821906983
148 (in isoform 2)Ubiquitination-44.7821906983
148UbiquitinationALREAAIKEETEYME
HHHHHHHHHHHHHHH		44.7821906983
148 (in isoform 1)Ubiquitination-44.7821906983
151O-linked_GlycosylationEAAIKEETEYMELLA
HHHHHHHHHHHHHHH		33.24OGP
153PhosphorylationAIKEETEYMELLAAE
HHHHHHHHHHHHHHH		11.87-
176O-linked_GlycosylationNMQHQNQSLSMLDEI
CCHHHHHHHHHHHHH		29.93OGP
206N-linked_GlycosylationEEHAFDDNKSVKGVN
HHHCCCCCCCCCCCC		40.10UniProtKB CARBOHYD
207UbiquitinationEHAFDDNKSVKGVNF
HHCCCCCCCCCCCCC		64.72-
210 (in isoform 3)Ubiquitination-65.3221906983
210UbiquitinationFDDNKSVKGVNFEAV
CCCCCCCCCCCCEEE		65.3221906983
210 (in isoform 2)Ubiquitination-65.3221906983
210 (in isoform 1)Ubiquitination-65.3221906983
227PhosphorylationVEEEEANSKQNITKR
HHHHHHHCCCCCCHH		42.5428985074
228UbiquitinationEEEEANSKQNITKRE
HHHHHHCCCCCCHHH		47.3621906983
228 (in isoform 1)Ubiquitination-47.3621906983
228 (in isoform 2)Ubiquitination-47.3621906983
228 (in isoform 3)Ubiquitination-47.3621906983
230N-linked_GlycosylationEEANSKQNITKREVE
HHHHCCCCCCHHHHC		47.86UniProtKB CARBOHYD
257 (in isoform 1)Ubiquitination-34.3121906983
257 (in isoform 2)Ubiquitination-34.3121906983
257 (in isoform 3)Ubiquitination-34.3121906983
257UbiquitinationNNQYILTKPRDSTIP
CCEEEECCCCCCCCC		34.312190698
378PhosphorylationHLLRIKPTQSVFIST
HHHCCCCCCHHHHHH		28.6027732954
380PhosphorylationLRIKPTQSVFISTCL
HCCCCCCHHHHHHHH		22.8227732954
384PhosphorylationPTQSVFISTCLSLSS
CCCHHHHHHHHHCCC		11.1227732954
385PhosphorylationTQSVFISTCLSLSST
CCHHHHHHHHHCCCC		16.7927732954
388PhosphorylationVFISTCLSLSSTPLV
HHHHHHHHCCCCHHH		28.4927732954
390PhosphorylationISTCLSLSSTPLVSR
HHHHHHCCCCHHHHH		28.8827732954
391PhosphorylationSTCLSLSSTPLVSRF
HHHHHCCCCHHHHHH		39.0627732954
392PhosphorylationTCLSLSSTPLVSRFL
HHHHCCCCHHHHHHH		19.7827732954
396PhosphorylationLSSTPLVSRFLMGSA
CCCCHHHHHHHHCCC		25.6227732954
480PhosphorylationLCLVIKKYLIGPYYR
HHHHHHHHHHHHHHH		9.8826074081
485PhosphorylationKKYLIGPYYRKLHME
HHHHHHHHHHHHHHC		15.6426074081
486PhosphorylationKYLIGPYYRKLHMES
HHHHHHHHHHHHHCC		12.3826074081
493PhosphorylationYRKLHMESKGNKEIL
HHHHHHCCCCCCCEE		37.9829978859
608PhosphorylationILPRSSQYIKWIVSA
HCCCCHHHHHHHHHC		13.3525954137
614PhosphorylationQYIKWIVSAGLAQVS
HHHHHHHHCCCCCHH		13.9025954137
621PhosphorylationSAGLAQVSEFSFVLG
HCCCCCHHHHHHHHC		22.3525954137
629PhosphorylationEFSFVLGSRARRAGV
HHHHHHCHHHHHHCC		20.7125954137
638PhosphorylationARRAGVISREVYLLI
HHHHCCCCHHHHHHH		21.7124719451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TMCO3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TMCO3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TMCO3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
TAP2_HUMANTAP2physical
28514442
COG4_HUMANCOG4physical
28514442
IFT57_HUMANIFT57physical
28514442
HEMK1_HUMANHEMK1physical
28514442
PM34_HUMANSLC25A17physical
28514442
TYK2_HUMANTYK2physical
28514442
PSME2_HUMANPSME2physical
28514442
ATG9A_HUMANATG9Aphysical
28514442
PXMP2_HUMANPXMP2physical
28514442
PIGQ_HUMANPIGQphysical
28514442
ERG1_HUMANSQLEphysical
28514442
GUF1_HUMANGUF1physical
28514442
POTEF_HUMANPOTEFphysical
28514442
CUL4B_HUMANCUL4Bphysical
28514442
AT132_HUMANATP13A2physical
28514442
SRBP2_HUMANSREBF2physical
28514442
TBB8_HUMANTUBB8physical
28514442
FADS1_HUMANFADS1physical
28514442
TBB3_HUMANTUBB3physical
28514442
DPH6_HUMANDPH6physical
28514442
TBA4A_HUMANTUBA4Aphysical
28514442
AT133_HUMANATP13A3physical
28514442
CUL4A_HUMANCUL4Aphysical
28514442
ADCK2_HUMANADCK2physical
28514442
STX17_HUMANSTX17physical
28514442
S26A6_HUMANSLC26A6physical
28514442
DCAF8_HUMANDCAF8physical
28514442
ADT3_HUMANSLC25A6physical
28514442
VKGC_HUMANGGCXphysical
28514442
PLCE_HUMANAGPAT5physical
28514442
BI1_HUMANTMBIM6physical
28514442
DAAF5_HUMANDNAAF5physical
28514442
MBRL_HUMANTMEM259physical
28514442
MET13_HUMANMETTL13physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TMCO3_HUMAN

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Related Literatures of Post-Translational Modification

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