JUPI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: JUPI1_HUMAN
• UniProt AC: Q9UK76
• Protein Name: Jupiter microtubule associated homolog 1 {ECO:0000312|HGNC:HGNC:14569}
• Gene Name: JPT1 {ECO:0000312|HGNC:HGNC:14569}
• Organism: Homo sapiens (Human).
• Sequence Length: 154
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Modulates negatively AKT-mediated GSK3B signaling. [PubMed: 21323578]
• Protein Sequence: MTTTTTFKGVDPNSRNSSRVLRPPGGGSNFSLGFDEPTEQPVRKNKMASNIFGTPEENQASWAKSAGAKSSGGREDLESSGLQRRNSSEASSGDFLDLKGEGDIHENVDTDLPGSLGQSEEKPVPAAPVPSPVAPAPVPSRRNPPGGKSSLVLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MTTTTTFK -------CCCEEEEC		22814378
2	Phosphorylation	------MTTTTTFKG ------CCCEEEECC		20068231
2	Acetylation	------MTTTTTFKG ------CCCEEEECC		22814378
3	Phosphorylation	-----MTTTTTFKGV -----CCCEEEECCC		20068231
4	Phosphorylation	----MTTTTTFKGVD ----CCCEEEECCCC		20068231
5	Phosphorylation	---MTTTTTFKGVDP ---CCCEEEECCCCC		20068231
6	Phosphorylation	--MTTTTTFKGVDPN --CCCEEEECCCCCC		20068231
8	Methylation	MTTTTTFKGVDPNSR CCCEEEECCCCCCCC		19608861
8	Ubiquitination	MTTTTTFKGVDPNSR CCCEEEECCCCCCCC		23000965
8	Phosphorylation	MTTTTTFKGVDPNSR CCCEEEECCCCCCCC		32142685
8 (in isoform 2)	Ubiquitination	-		-
8 (in isoform 3)	Phosphorylation	-		25159151
8	Acetylation	MTTTTTFKGVDPNSR CCCEEEECCCCCCCC		23954790
14	Phosphorylation	FKGVDPNSRNSSRVL ECCCCCCCCCCCCEE		25159151
17	Phosphorylation	VDPNSRNSSRVLRPP CCCCCCCCCCEECCC		25159151
18 (in isoform 3)	Ubiquitination	-		21906983
18	Ubiquitination	DPNSRNSSRVLRPPG CCCCCCCCCEECCCC		23000965
18	Phosphorylation	DPNSRNSSRVLRPPG CCCCCCCCCEECCCC		30140170
22	Methylation	RNSSRVLRPPGGGSN CCCCCEECCCCCCCC		115478831
23 (in isoform 3)	Ubiquitination	-		21906983
23	Ubiquitination	NSSRVLRPPGGGSNF CCCCEECCCCCCCCC		23000965
28	Phosphorylation	LRPPGGGSNFSLGFD ECCCCCCCCCCCCCC		23401153
31	Phosphorylation	PGGGSNFSLGFDEPT CCCCCCCCCCCCCCC		25159151
38	Phosphorylation	SLGFDEPTEQPVRKN CCCCCCCCCCCCHHH		23403867
41	Phosphorylation	FDEPTEQPVRKNKMA CCCCCCCCCHHHCCH		33259812
42	Phosphorylation	DEPTEQPVRKNKMAS CCCCCCCCHHHCCHH		32142685
44	Ubiquitination	PTEQPVRKNKMASNI CCCCCCHHHCCHHHC		23000965
46	Ubiquitination	EQPVRKNKMASNIFG CCCCHHHCCHHHCCC		23000965
46 (in isoform 1)	Ubiquitination	-		21906983
46 (in isoform 2)	Ubiquitination	-		21906983
46	Phosphorylation	EQPVRKNKMASNIFG CCCCHHHCCHHHCCC		32142685
46	Acetylation	EQPVRKNKMASNIFG CCCCHHHCCHHHCCC		25953088
47	Sulfoxidation	QPVRKNKMASNIFGT CCCHHHCCHHHCCCC		28183972
49	Phosphorylation	VRKNKMASNIFGTPE CHHHCCHHHCCCCCH		23927012
54	O-linked_Glycosylation	MASNIFGTPEENQAS CHHHCCCCCHHHHHH		OGP
54	Phosphorylation	MASNIFGTPEENQAS CHHHCCCCCHHHHHH		23927012
61	Phosphorylation	TPEENQASWAKSAGA CCHHHHHHHHHHCCC		30266825
64	Ubiquitination	ENQASWAKSAGAKSS HHHHHHHHHCCCCCC		23000965
64	Acetylation	ENQASWAKSAGAKSS HHHHHHHHHCCCCCC		26051181
64 (in isoform 2)	Ubiquitination	-		21906983
64 (in isoform 1)	Ubiquitination	-		21906983
65	Phosphorylation	NQASWAKSAGAKSSG HHHHHHHHCCCCCCC		29396449
69 (in isoform 1)	Ubiquitination	-		21906983
69	Acetylation	WAKSAGAKSSGGRED HHHHCCCCCCCCHHH		25953088
69	Ubiquitination	WAKSAGAKSSGGRED HHHHCCCCCCCCHHH		23000965
69 (in isoform 2)	Ubiquitination	-		21906983
70	Phosphorylation	AKSAGAKSSGGREDL HHHCCCCCCCCHHHH		25159151
71	Phosphorylation	KSAGAKSSGGREDLE HHCCCCCCCCHHHHH		25159151
79	Phosphorylation	GGREDLESSGLQRRN CCHHHHHHHCCCCCC		23401153
80	Phosphorylation	GREDLESSGLQRRNS CHHHHHHHCCCCCCC		29255136
85	Phosphorylation	ESSGLQRRNSSEASS HHHCCCCCCCCCCCC		32142685
87 (in isoform 2)	Phosphorylation	-		26657352
87	Phosphorylation	SGLQRRNSSEASSGD HCCCCCCCCCCCCCC		19664994
88 (in isoform 2)	Phosphorylation	-		29116813
88	Phosphorylation	GLQRRNSSEASSGDF CCCCCCCCCCCCCCC		29255136
91 (in isoform 2)	Phosphorylation	-		25159151
91	Phosphorylation	RRNSSEASSGDFLDL CCCCCCCCCCCCCCC		23927012
92	Phosphorylation	RNSSEASSGDFLDLK CCCCCCCCCCCCCCC		23927012
92 (in isoform 2)	Phosphorylation	-		20886841
102	Ubiquitination	FLDLKGEGDIHENVD CCCCCCCCCCCCCCC		24816145
102	Acetylation	FLDLKGEGDIHENVD CCCCCCCCCCCCCCC		19608861
110	Phosphorylation	DIHENVDTDLPGSLG CCCCCCCCCCCCCCC		30576142
115	Phosphorylation	VDTDLPGSLGQSEEK CCCCCCCCCCCCCCC		23927012
119	Phosphorylation	LPGSLGQSEEKPVPA CCCCCCCCCCCCCCC		23927012
131	O-linked_Glycosylation	VPAAPVPSPVAPAPV CCCCCCCCCCCCCCC		OGP
131	Phosphorylation	VPAAPVPSPVAPAPV CCCCCCCCCCCCCCC		29255136
140	Phosphorylation	VAPAPVPSRRNPPGG CCCCCCCCCCCCCCC		29255136
148	Methylation	RRNPPGGKSSLVLG- CCCCCCCCCCCCCC-		22641163
148	Acetylation	RRNPPGGKSSLVLG- CCCCCCCCCCCCCC-		19608861
148	Ubiquitination	RRNPPGGKSSLVLG- CCCCCCCCCCCCCC-		24816145
149	Phosphorylation	RNPPGGKSSLVLG-- CCCCCCCCCCCCC--		23911959
150	Phosphorylation	NPPGGKSSLVLG--- CCCCCCCCCCCC---		22617229

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of JUPI1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of JUPI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of JUPI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHG44_HUMAN	ARHGAP44	physical	16169070
IMA1_HUMAN	KPNA2	physical	22939629
MPPB_HUMAN	PMPCB	physical	22939629
SEPT9_HUMAN	SEPT9	physical	22939629

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.