CF251_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CF251_HUMAN
• UniProt AC: Q8TBY9
• Protein Name: Cilia- and flagella-associated protein 251 {ECO:0000305}
• Gene Name: WDR66 {ECO:0000312|HGNC:HGNC:28506}
• Organism: Homo sapiens (Human).
• Sequence Length: 1149
• Subcellular Localization: Cytoplasm, cytoskeleton, cilium axoneme .
• Protein Description: May regulate cilium motility through its role in the assembly of the axonemal radial spokes..
• Protein Sequence: MSDAAEAPREATGENGETEMKEEEEPNPNYKEVEDPQQESKDDTIAWRESQEEERKTGEEEGEEEGKEDKKIVMEETEEKAGEVQEKEASGIQEETTVEPQEVTASMIRLETQITDSQSITSGIFPKTQRGSKSKLSLQLEDAETDELLRDLSTQIEFLDLDQISPEEQQISSPERQPSGELEEKTDRMPQDELGQERRDLEPENREEGQERRVSDIQSKAGISRESLVSSTTEDILFQKDKSTPVYPLTMTWSFGWNSSLPVYYIREERQRVLLYVCAHTAIIYNVFRNNQYHLQGHANIISCLCVSEDRRWIATADKGPDCLVIIWDSFTGIPVHTIFDSCPEGNGIMAMAMTHDAKYLATISDAEVQKVCIWKWTLAVETPACTLELPTEYGVQNYVTFNPTNNKELVSNSKTRAIYYAWYEERDTLAHSAPLLTEKTFNKLVGKFSQSIFHLNLTQILSATMEGKLVVWDIHRPPSSASTFLGFPYIKPCKLVHLQKEGITVLTTIDSYIVTGDIKGNIKFYDHTLSIVNWYSHLKLGAIRTLSFSKTPATPPTEKSNYPPDCTLKGDLFVLRNFIIGTSDAAVYHLTTDGTKLEKLFVEPKDAICAISCHPYQPLIAIGSICGMIKVWNYENKQYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFKYSRTSVTHISFSHDSQYMATADRSFTVAVYMLVVRNGQRVWEYLARLRSHRKSIRSLLFGVYLDSNEPRLLSLGTDRLLIEYDLLRSYKDHLEVLDIHHTDQGCYPTCMVWYPPLTRELFLLICNSGYKVKLFNATTKMCRKTLLGPAYGSPIEQTQVLPVRSMAELQKRYLVFINRDKVGLQILPVDGNPHKTSAIVCHPNGVAGMAVSYDGCYAFTAGGHDRSVVQWKITLSVLEAAVSLGGEDLTPFYGLLSGGREGKFYRELEDYFYYSQLRSQGIDTMETRKVSEHICLSELPFVMRAIGFYPSEEKIDDIFNEIKFGEYVDTGKLIDKINLPDFLKVYLNHKPPFGNTMSGIHKSFEVLGYTNSKGKKAIRREDFLRLLVTKGEHMTEEEMLDCFASLFGLNPEGWKSEPATCSVKGSEICLEEELPDEITAEIFATEILGLTISEDSGQDGQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	ATGENGETEMKEEEE HCCCCCCCCCCCCCC		-
77	Phosphorylation	KKIVMEETEEKAGEV CEEEEHHHHHHHHCC		29449344
96	Phosphorylation	ASGIQEETTVEPQEV CCCCCCCCCCCCHHH		30576142
104	Phosphorylation	TVEPQEVTASMIRLE CCCCHHHHHEEEEEE		30576142
106	Phosphorylation	EPQEVTASMIRLETQ CCHHHHHEEEEEEEE		30576142
112	Phosphorylation	ASMIRLETQITDSQS HEEEEEEEEEECCCC		25693802
115	Phosphorylation	IRLETQITDSQSITS EEEEEEEECCCCCCC		25693802
117	Phosphorylation	LETQITDSQSITSGI EEEEEECCCCCCCCC		25693802
119	Phosphorylation	TQITDSQSITSGIFP EEEECCCCCCCCCCC		25693802
121	Phosphorylation	ITDSQSITSGIFPKT EECCCCCCCCCCCCC		25693802
122	Phosphorylation	TDSQSITSGIFPKTQ ECCCCCCCCCCCCCC		25693802
134	Phosphorylation	KTQRGSKSKLSLQLE CCCCCCCCEEEEEEH		30622161
137	Phosphorylation	RGSKSKLSLQLEDAE CCCCCEEEEEEHHHC		30622161
215	Phosphorylation	EGQERRVSDIQSKAG HHHHHCHHHHHHHHC		30622161
219	Phosphorylation	RRVSDIQSKAGISRE HCHHHHHHHHCCCHH		22964224
224	Phosphorylation	IQSKAGISRESLVSS HHHHHCCCHHHHCCC		30622161
227	Phosphorylation	KAGISRESLVSSTTE HHCCCHHHHCCCCHH		30622161
230	Phosphorylation	ISRESLVSSTTEDIL CCHHHHCCCCHHHHH		30622161
231	Phosphorylation	SRESLVSSTTEDILF CHHHHCCCCHHHHHC		30622161
232	Phosphorylation	RESLVSSTTEDILFQ HHHHCCCCHHHHHCC		30622161
233	Phosphorylation	ESLVSSTTEDILFQK HHHCCCCHHHHHCCC		30622161
316	Phosphorylation	EDRRWIATADKGPDC CCCEEEEECCCCCCE		22210691
338	Phosphorylation	FTGIPVHTIFDSCPE CCCCCHHHHHCCCCC		22210691
429	Phosphorylation	AWYEERDTLAHSAPL EEHHHHCCCCHHCCC		-
441	Phosphorylation	APLLTEKTFNKLVGK CCCCCHHHHHHHHHH		-
548	Phosphorylation	LGAIRTLSFSKTPAT CCCEEEEECCCCCCC		24719451
714	Phosphorylation	YMATADRSFTVAVYM CEEECCCCCEEEEEE		-
720	Phosphorylation	RSFTVAVYMLVVRNG CCCEEEEEEEEEECC		-
743	Phosphorylation	RLRSHRKSIRSLLFG HHHHCHHHHHHHHHE		24719451
818	Phosphorylation	LLICNSGYKVKLFNA HHHHCCCCCEEEEEC		28258704
828	Ubiquitination	KLFNATTKMCRKTLL EEEECCCHHHHHHHC		23000965
832	Ubiquitination	ATTKMCRKTLLGPAY CCCHHHHHHHCCCCC		23000965
833	Phosphorylation	TTKMCRKTLLGPAYG CCHHHHHHHCCCCCC		22468782
839	Phosphorylation	KTLLGPAYGSPIEQT HHHCCCCCCCCCCCC		22468782
846	Phosphorylation	YGSPIEQTQVLPVRS CCCCCCCCCEEECCC		22468782
853	Phosphorylation	TQVLPVRSMAELQKR CCEEECCCHHHHHHC		30622161
972	Phosphorylation	LRSQGIDTMETRKVS HHHCCCCHHHCCCCC		-
979	Phosphorylation	TMETRKVSEHICLSE HHHCCCCCCCCHHHH		-
1015	Phosphorylation	NEIKFGEYVDTGKLI HHHCCCCCCCCCCCC		28270605
1018	Phosphorylation	KFGEYVDTGKLIDKI CCCCCCCCCCCCCCC		28270605
1024	Acetylation	DTGKLIDKINLPDFL CCCCCCCCCCCCHHH		25038526
1038	Acetylation	LKVYLNHKPPFGNTM HHHHHHCCCCCCCCC		11792809
1051	Phosphorylation	TMSGIHKSFEVLGYT CCCHHHHHEEECCEE		17924679
1057	Phosphorylation	KSFEVLGYTNSKGKK HHEEECCEECCCCCE		29083192
1058	Phosphorylation	SFEVLGYTNSKGKKA HEEECCEECCCCCEE		17924679
1060	Phosphorylation	EVLGYTNSKGKKAIR EECCEECCCCCEEEC		17924679
1061	Acetylation	VLGYTNSKGKKAIRR ECCEECCCCCEEECH		11792817
1077	Phosphorylation	DFLRLLVTKGEHMTE HHHHHHCCCCCCCCH		24114839

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CF251_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CF251_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CF251_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CF251_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.