PHLA1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PHLA1_HUMAN
• UniProt AC: Q8WV24
• Protein Name: Pleckstrin homology-like domain family A member 1
• Gene Name: PHLDA1
• Organism: Homo sapiens (Human).
• Sequence Length: 401
• Subcellular Localization: Cytoplasm . Cytoplasmic vesicle . Nucleus, nucleolus . Colocalizes with intracellular vesicles.
• Protein Description: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation..
• Protein Sequence: MRRAPAAERLLELGFPPRCGRQEPPFPLGVTRGWGRWPIQKRREGARPVPFSERSQEDGRGPAARSSGTLWRIRTRLSLCRDPEPPPPLCLLRVSLLCALRAGGRGSRWGEDGARLLLLPPARAAGNGEAEPSGGPSYAGRMLESSGCKALKEGVLEKRSDGLLQLWKKKCCILTEEGLLLIPPKQLQHQQQQQQQQQQQQQQQPGQGPAEPSQPSGPAVASLEPPVKLKELHFSNMKTVDCVERKGKYMYFTVVMAEGKEIDFRCPQDQGWNAEITLQMVQYKNRQAILAVKSTRQKQQHLVQQQPPSQPQPQPQLQPQPQPQPQPQPQPQSQPQPQPQPKPQPQQLHPYPHPHPHPHSHPHSHPHPHPHPHPHQIPHPHPQPHSQPHGHRLLRSTSNSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
95	Phosphorylation	PLCLLRVSLLCALRA CEEHHHHHHHHHHHC	14.80	-
137	Phosphorylation	AEPSGGPSYAGRMLE CCCCCCCCHHHHHHH	30.78	22210691
138	Phosphorylation	EPSGGPSYAGRMLES CCCCCCCHHHHHHHH	19.06	22210691
145	Phosphorylation	YAGRMLESSGCKALK HHHHHHHHHHCHHHH	28.24	22210691
146	Phosphorylation	AGRMLESSGCKALKE HHHHHHHHHCHHHHH	38.54	22210691
149	Ubiquitination	MLESSGCKALKEGVL HHHHHHCHHHHHCHH	61.35	23503661
152	Ubiquitination	SSGCKALKEGVLEKR HHHCHHHHHCHHHCC	58.23	21906983
158	Ubiquitination	LKEGVLEKRSDGLLQ HHHCHHHCCCCCHHH	53.71	27667366
160	Phosphorylation	EGVLEKRSDGLLQLW HCHHHCCCCCHHHHH	47.28	27251275
168	Acetylation	DGLLQLWKKKCCILT CCHHHHHHHCCEEEE	51.45	30591295
168	Ubiquitination	DGLLQLWKKKCCILT CCHHHHHHHCCEEEE	51.45	21906983
169	Ubiquitination	GLLQLWKKKCCILTE CHHHHHHHCCEEEEC	39.19	23503661
170	Ubiquitination	LLQLWKKKCCILTEE HHHHHHHCCEEEECC	30.52	23503661
228	Ubiquitination	ASLEPPVKLKELHFS CCCCCCCCHHEECCC	60.66	22817900
230	Ubiquitination	LEPPVKLKELHFSNM CCCCCCHHEECCCCC	53.14	27667366
238	Acetylation	ELHFSNMKTVDCVER EECCCCCEEEECEEE	50.04	20167786
238	Ubiquitination	ELHFSNMKTVDCVER EECCCCCEEEECEEE	50.04	29967540
293	Ubiquitination	RQAILAVKSTRQKQQ HHHEEEEECHHHHHH	40.27	21906983
294	Phosphorylation	QAILAVKSTRQKQQH HHEEEEECHHHHHHH	23.40	27470641
298	Ubiquitination	AVKSTRQKQQHLVQQ EEECHHHHHHHHHHC	48.94	23503661
396	Phosphorylation	HGHRLLRSTSNSA-- CCHHHCCCCCCCC--	35.84	22199227
397	Phosphorylation	GHRLLRSTSNSA--- CHHHCCCCCCCC---	26.03	29514088
398	Phosphorylation	HRLLRSTSNSA---- HHHCCCCCCCC----	29.99	29514088
400	Phosphorylation	LLRSTSNSA------ HCCCCCCCC------	34.81	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
95	S	Phosphorylation	Kinase	AURKA	O14965	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PHLA1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PHLA1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KR412_HUMAN	KRTAP4-12	physical	16189514
RL14_HUMAN	RPL14	physical	11369516
PABP4_HUMAN	PABPC4	physical	11369516
EIF3D_HUMAN	EIF3D	physical	11369516
HSP74_HUMAN	HSPA4	physical	17024176
DNJB1_HUMAN	DNAJB1	physical	17024176
A4_HUMAN	APP	physical	21832049
MDFI_HUMAN	MDFI	physical	19060904

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.