NEUR4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NEUR4_HUMAN
• UniProt AC: Q8WWR8
• Protein Name: Sialidase-4
• Gene Name: NEU4
• Organism: Homo sapiens (Human).
• Sequence Length: 484
• Subcellular Localization: Isoform 1: Membrane; Peripheral membrane protein.; Isoform 2: Lysosome lumen. According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predicted fr
• Protein Description: May function in lysosomal catabolism of sialylated glycoconjugates. Has sialidase activity towards synthetic substrates, such as 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid (4-MU-NANA or 4MU-NeuAc). Has a broad substrate specificity being active on glycoproteins, oligosaccharides and sialylated glycolipids..
• Protein Sequence: MGVPRTPSRTVLFERERTGLTYRVPSLLPVPPGPTLLAFVEQRLSPDDSHAHRLVLRRGTLAGGSVRWGALHVLGTAALAEHRSMNPCPVHDAGTGTVFLFFIAVLGHTPEAVQIATGRNAARLCCVASRDAGLSWGSARDLTEEAIGGAVQDWATFAVGPGHGVQLPSGRLLVPAYTYRVDRRECFGKICRTSPHSFAFYSDDHGRTWRCGGLVPNLRSGECQLAAVDGGQAGSFLYCNARSPLGSRVQALSTDEGTSFLPAERVASLPETAWGCQGSIVGFPAPAPNRPRDDSWSVGPGSPLQPPLLGPGVHEPPEEAAVDPRGGQVPGGPFSRLQPRGDGPRQPGPRPGVSGDVGSWTLALPMPFAAPPQSPTWLLYSHPVGRRARLHMGIRLSQSPLDPRSWTEPWVIYEGPSGYSDLASIGPAPEGGLVFACLYESGARTSYDEISFCTFSLREVLENVPASPKPPNLGDKPRGCCWPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MGVPRTPSRTVLFER CCCCCCCCCEEEEEE	39.71	28674151
10	Phosphorylation	VPRTPSRTVLFERER CCCCCCCEEEEEEEC	26.37	-
12 (in isoform 2)	Phosphorylation	-	3.50	-
13 (in isoform 3)	Phosphorylation	-	7.85	-
18	Phosphorylation	VLFERERTGLTYRVP EEEEEECCCCEEEEC	31.61	-
20 (in isoform 2)	Phosphorylation	-	3.63	17081983
21 (in isoform 3)	Phosphorylation	-	15.61	-
21	Phosphorylation	ERERTGLTYRVPSLL EEECCCCEEEECCCC	15.61	-
22	Phosphorylation	RERTGLTYRVPSLLP EECCCCEEEECCCCC	18.04	-
177	Phosphorylation	GRLLVPAYTYRVDRR CCEEEEEEEEEECHH	9.76	24670416
179	Phosphorylation	LLVPAYTYRVDRREC EEEEEEEEEECHHHH	8.93	24670416
193	Phosphorylation	CFGKICRTSPHSFAF HCHHHCCCCCCCEEE	42.05	-
194	Phosphorylation	FGKICRTSPHSFAFY CHHHCCCCCCCEEEE	10.98	-
197	Phosphorylation	ICRTSPHSFAFYSDD HCCCCCCCEEEEECC	22.96	-
202	Phosphorylation	PHSFAFYSDDHGRTW CCCEEEEECCCCCEE	30.06	-
335	Phosphorylation	QVPGGPFSRLQPRGD CCCCCCCCCCCCCCC	34.90	24670416
399	Phosphorylation	MGIRLSQSPLDPRSW EEEECCCCCCCCCCC	24.85	26852163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NEUR4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NEUR4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NEUR4_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHXF2_HUMAN	RHOXF2	physical	19447967
MDFI_HUMAN	MDFI	physical	19447967
MDFI_HUMAN	MDFI	physical	19060904
MDFI_HUMAN	MDFI	physical	21516116
TRIP6_HUMAN	TRIP6	physical	21516116
RUSD2_HUMAN	RPUSD2	physical	28514442
ZPR1_HUMAN	ZPR1	physical	28514442
GILT_HUMAN	IFI30	physical	28514442
ZMY19_HUMAN	ZMYND19	physical	28514442
GRAN_HUMAN	GCA	physical	28514442
CH60_HUMAN	HSPD1	physical	28514442
LONM_HUMAN	LONP1	physical	28514442
AIP_HUMAN	AIP	physical	28514442
SGT1_HUMAN	SUGT1	physical	28514442
GID4_HUMAN	GID4	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.