| UniProt ID | DHB8_HUMAN | |
|---|---|---|
| UniProt AC | Q92506 | |
| Protein Name | Estradiol 17-beta-dehydrogenase 8 | |
| Gene Name | HSD17B8 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 261 | |
| Subcellular Localization | Mitochondrion matrix . | |
| Protein Description | NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. [PubMed: 17978863 The heterotetramer with CBR4 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis] | |
| Protein Sequence | MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 11 | Phosphorylation | QLQNRLRSALALVTG HHHHHHHHHHHHHHC | 32.02 | 23403867 | |
| 17 | Phosphorylation | RSALALVTGAGSGIG HHHHHHHHCCCCCCC | 23.36 | 23403867 | |
| 21 | Phosphorylation | ALVTGAGSGIGRAVS HHHHCCCCCCCHHHH | 27.06 | 23403867 | |
| 60 | Phosphorylation | RLLGGPGSKEGPPRG HHHCCCCCCCCCCCC | 30.57 | 22985185 | |
| 160 | Succinylation | NISSIVGKVGNVGQT EHHHHHHCCCCCCCH | 35.75 | - | |
| 160 | Succinylation | NISSIVGKVGNVGQT EHHHHHHCCCCCCCH | 35.75 | - | |
| 169 | Phosphorylation | GNVGQTNYAASKAGV CCCCCHHHHHHHHCC | 13.61 | - | |
| 173 | Succinylation | QTNYAASKAGVIGLT CHHHHHHHHCCCCHH | 44.42 | - | |
| 173 | Ubiquitination | QTNYAASKAGVIGLT CHHHHHHHHCCCCHH | 44.42 | - | |
| 173 | Succinylation | QTNYAASKAGVIGLT CHHHHHHHHCCCCHH | 44.42 | - | |
| 207 | Phosphorylation | GFIATPMTQKVPQKV CCCCCCCCCCCCHHH | 26.83 | 20860994 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DHB8_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DHB8_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DHB8_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| CBR4_HUMAN | CBR4 | physical | 26186194 | |
| MOCOS_HUMAN | MOCOS | physical | 26186194 | |
| RT23_HUMAN | MRPS23 | physical | 26186194 | |
| IF2M_HUMAN | MTIF2 | physical | 26186194 | |
| RT02_HUMAN | MRPS2 | physical | 26186194 | |
| ARFP1_HUMAN | ARFIP1 | physical | 26344197 | |
| DHPR_HUMAN | QDPR | physical | 26344197 | |
| MOCOS_HUMAN | MOCOS | physical | 28514442 | |
| HNRPF_HUMAN | HNRNPF | physical | 28514442 | |
| CBR4_HUMAN | CBR4 | physical | 28514442 | |
| IF2M_HUMAN | MTIF2 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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