CBR4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBR4_HUMAN
• UniProt AC: Q8N4T8
• Protein Name: Carbonyl reductase family member 4
• Gene Name: CBR4
• Organism: Homo sapiens (Human).
• Sequence Length: 237
• Subcellular Localization: Mitochondrion matrix .
• Protein Description: The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. [PubMed: 19571038]
• Protein Sequence: MDKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVVAPGFVHTDMTKDLKEEHLKKNIPLGRFGETIEVAHAVVFLLESPYITGHVLVVDGGLQLIL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDKVCAVF -------CCCEEEEC	11.53	22814378
3	Acetylation	-----MDKVCAVFGG -----CCCEEEECCC	37.60	25038526
11	Phosphorylation	VCAVFGGSRGIGRAV EEEECCCCCHHHHHH	27.93	29449344
40	Acetylation	ARNLEGAKAAAGDLG EECCHHHHHHCCCCC	49.79	-
51	Ubiquitination	GDLGGDHLAFSCDVA CCCCCCEEEEECCHH	6.48	22817900
59	Acetylation	AFSCDVAKEHDVQNT EEECCHHHHCHHHHH	56.27	25038526
63	Ubiquitination	DVAKEHDVQNTFEEL CHHHHCHHHHHHHHH	5.22	21890473
96	Acetylation	DGLLVRTKTEDMVSQ CCCEEEECCHHHHHH	39.08	25038526
96	Ubiquitination	DGLLVRTKTEDMVSQ CCCEEEECCHHHHHH	39.08	21890473
96 (in isoform 2)	Ubiquitination	-	39.08	21890473
96 (in isoform 1)	Ubiquitination	-	39.08	21890473
98	Ubiquitination	LLVRTKTEDMVSQLH CEEEECCHHHHHHHH	45.74	21890473
101	Ubiquitination	RTKTEDMVSQLHTNL EECCHHHHHHHHHHH	5.22	27667366
111	Phosphorylation	LHTNLLGSMLTCKAA HHHHHHHHHHHHHHH	15.58	-
114	Phosphorylation	NLLGSMLTCKAAMRT HHHHHHHHHHHHHHH	11.88	-
121	Phosphorylation	TCKAAMRTMIQQQGG HHHHHHHHHHHHCCC	12.92	22210691
140 (in isoform 2)	Ubiquitination	-	50.55	21890473
140 (in isoform 1)	Ubiquitination	-	50.55	21890473
140	Ubiquitination	VGSIVGLKGNSGQSV ECCEEEEECCCCCCE	50.55	21890473
145	Ubiquitination	GLKGNSGQSVYSASK EEECCCCCCEEECCC	29.55	27667366
150	Ubiquitination	SGQSVYSASKGGLVG CCCCEEECCCCCHHH	9.51	22817900
152	Ubiquitination	QSVYSASKGGLVGFS CCEEECCCCCHHHHH	57.63	22817900
152 (in isoform 2)	Ubiquitination	-	57.63	21890473
152 (in isoform 1)	Ubiquitination	-	57.63	21890473
159	Phosphorylation	KGGLVGFSRALAKEV CCCHHHHHHHHHHHH	15.66	22210691
162	Ubiquitination	LVGFSRALAKEVARK HHHHHHHHHHHHHHH	7.32	21890473
187	Ubiquitination	FVHTDMTKDLKEEHL CCCCCCCHHHHHHHH	55.19	21890473
187 (in isoform 1)	Ubiquitination	-	55.19	21890473
190	Acetylation	TDMTKDLKEEHLKKN CCCCHHHHHHHHHHC	71.80	25953088
190	Ubiquitination	TDMTKDLKEEHLKKN CCCCHHHHHHHHHHC	71.80	27667366
195	Acetylation	DLKEEHLKKNIPLGR HHHHHHHHHCCCCCC	45.76	2380547
196	Succinylation	LKEEHLKKNIPLGRF HHHHHHHHCCCCCCH	67.48	27452117
197	Ubiquitination	KEEHLKKNIPLGRFG HHHHHHHCCCCCCHH	39.25	21890473
200	Ubiquitination	HLKKNIPLGRFGETI HHHHCCCCCCHHHHH	7.33	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBR4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBR4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBR4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CBR4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.