TXN4B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TXN4B_HUMAN
• UniProt AC: Q9NX01
• Protein Name: Thioredoxin-like protein 4B
• Gene Name: TXNL4B
• Organism: Homo sapiens (Human).
• Sequence Length: 149
• Subcellular Localization: Nucleus .
• Protein Description: Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition..
• Protein Sequence: MSFLLPKLTSKKEVDQAIKSTAEKVLVLRFGRDEDPVCLQLDDILSKTSSDLSKMAAIYLVDVDQTAVYTQYFDISYIPSTVFFFNGQHMKVDYGSPDHTKFVGSFKTKQDFIDLIEVIYRGAMRGKLIVQSPIDPKNIPKYDLLYQDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFLLPKLT ------CCCCHHHCC	25.30	24719451
7	Ubiquitination	-MSFLLPKLTSKKEV -CCCCHHHCCCHHHH	65.45	22505724
9	Phosphorylation	SFLLPKLTSKKEVDQ CCCHHHCCCHHHHHH	44.63	24719451
19	Ubiquitination	KEVDQAIKSTAEKVL HHHHHHHHHHHCEEE	44.78	33845483
24	Ubiquitination	AIKSTAEKVLVLRFG HHHHHHCEEEEEEEC	38.10	-
47	Ubiquitination	QLDDILSKTSSDLSK EHHHHHHHCCCHHHH	49.32	29967540
53	Ubiquitination	SKTSSDLSKMAAIYL HHCCCHHHHCEEEEE	25.94	27667366
83	Ubiquitination	SYIPSTVFFFNGQHM ECCCCEEEEECCEEE	6.15	29967540
87	Ubiquitination	STVFFFNGQHMKVDY CEEEEECCEEEEECC	17.39	29967540
96	Phosphorylation	HMKVDYGSPDHTKFV EEEECCCCCCCCCEE	22.41	25159151
101	Ubiquitination	YGSPDHTKFVGSFKT CCCCCCCCEEECCCC	34.33	29967540
107	Ubiquitination	TKFVGSFKTKQDFID CCEEECCCCHHHHHH	57.41	27667366
127	Ubiquitination	YRGAMRGKLIVQSPI HHHHHCCCEEEECCC	25.36	-
127	Acetylation	YRGAMRGKLIVQSPI HHHHHCCCEEEECCC	25.36	25953088
132	Phosphorylation	RGKLIVQSPIDPKNI CCCEEEECCCCCCCC	16.96	30266825
137	Ubiquitination	VQSPIDPKNIPKYDL EECCCCCCCCCCHHC	64.86	29967540
141	Ubiquitination	IDPKNIPKYDLLYQD CCCCCCCCHHCEECC	47.82	29967540
142	Phosphorylation	DPKNIPKYDLLYQDI CCCCCCCHHCEECCC	13.38	28796482
146	Phosphorylation	IPKYDLLYQDI---- CCCHHCEECCC----	16.07	28796482

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TXN4B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TXN4B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TXN4B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRP6_HUMAN	PRPF6	physical	15161931
XPO1_HUMAN	XPO1	physical	21048991
RIOK2_HUMAN	RIOK2	physical	21048991
NOB1_HUMAN	NOB1	physical	21048991
RS3_HUMAN	RPS3	physical	21048991
PKHF2_HUMAN	PLEKHF2	physical	25416956
PNMA5_HUMAN	PNMA5	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132, AND MASSSPECTROMETRY.
PubMed: 18669648