TPSNR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPSNR_HUMAN
• UniProt AC: Q9BX59
• Protein Name: Tapasin-related protein
• Gene Name: TAPBPL
• Organism: Homo sapiens (Human).
• Sequence Length: 468
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Microsome membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single-pass type I membrane protein . M
• Protein Description: Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression..
• Protein Sequence: MGTQEGWCLLLCLALSGAAETKPHPAEGQWRAVDVVLDCFLAKDGAHRGALASSEDRARASLVLKQVPVLDDGSLEDFTDFQGGTLAQDDPPIIFEASVDLVQIPQAEALLHADCSGKEVTCEISRYFLQMTETTVKTAAWFMANMQVSGGGPSISLVMKTPRVTKNEALWHPTLNLPLSPQGTVRTAVEFQVMTQTQSLSFLLGSSASLDCGFSMAPGLDLISVEWRLQHKGRGQLVYSWTAGQGQAVRKGATLEPAQLGMARDASLTLPGLTIQDEGTYICQITTSLYRAQQIIQLNIQASPKVRLSLANEALLPTLICDIAGYYPLDVVVTWTREELGGSPAQVSGASFSSLRQSVAGTYSISSSLTAEPGSAGATYTCQVTHISLEEPLGASTQVVPPERRTALGVIFASSLFLLALMFLGLQRRQAPTGLGLLQAERWETTSCADTQSSHLHEDRTARVSQPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Ubiquitination	VLDCFLAKDGAHRGA HHHHEEECCCCCCCC	59.86	-
61	Phosphorylation	SEDRARASLVLKQVP HHHHHHHHHEEEECC	17.29	23898821
121	Ubiquitination	DCSGKEVTCEISRYF CCCCCEEEHHHHHHH	12.91	24816145
127	Phosphorylation	VTCEISRYFLQMTET EEHHHHHHHHHHCCC	11.23	22210691
132	Phosphorylation	SRYFLQMTETTVKTA HHHHHHHCCCCHHHH	19.74	22210691
134	Phosphorylation	YFLQMTETTVKTAAW HHHHHCCCCHHHHHH	27.94	22210691
135	Phosphorylation	FLQMTETTVKTAAWF HHHHCCCCHHHHHHH	17.48	22210691
138	Phosphorylation	MTETTVKTAAWFMAN HCCCCHHHHHHHHHC	19.78	29083192
149	Phosphorylation	FMANMQVSGGGPSIS HHHCCCCCCCCCCEE	18.15	29083192
156	Phosphorylation	SGGGPSISLVMKTPR CCCCCCEEEEEECCC	21.17	22210691
161	Phosphorylation	SISLVMKTPRVTKNE CEEEEEECCCCCCCC	9.76	22210691
251	Ubiquitination	GQGQAVRKGATLEPA CCCCCCCCCCCCCHH	46.42	24816145
254	O-linked_Glycosylation	QAVRKGATLEPAQLG CCCCCCCCCCHHHCC	40.08	55831853
343	Phosphorylation	TREELGGSPAQVSGA EHHHHCCCCCEECCC	18.44	-
354	Phosphorylation	VSGASFSSLRQSVAG ECCCCHHHHHHHHCC	26.09	24719451
406	Phosphorylation	VVPPERRTALGVIFA ECCHHHHHHHHHHHH	32.24	-
415	Phosphorylation	LGVIFASSLFLLALM HHHHHHHHHHHHHHH	21.51	-
446	Phosphorylation	QAERWETTSCADTQS EEECCEECCCCCCCC	15.42	28348404
447	Phosphorylation	AERWETTSCADTQSS EECCEECCCCCCCCC	18.09	28348404
451	Phosphorylation	ETTSCADTQSSHLHE EECCCCCCCCCCCCC	16.30	27251275
453	Phosphorylation	TSCADTQSSHLHEDR CCCCCCCCCCCCCCC	23.09	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPSNR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPSNR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPSNR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
K1C40_HUMAN	KRT40	physical	25416956
KR107_HUMAN	KRTAP10-7	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.