NDOR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDOR1_HUMAN
• UniProt AC: Q9UHB4
• Protein Name: NADPH-dependent diflavin oxidoreductase 1 {ECO:0000255|HAMAP-Rule:MF_03178}
• Gene Name: NDOR1 {ECO:0000255|HAMAP-Rule:MF_03178}
• Organism: Homo sapiens (Human).
• Sequence Length: 597
• Subcellular Localization: Cytoplasm, perinuclear region . Concentrated in perinuclear structure.
• Protein Description: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins (By similarity). Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1..
• Protein Sequence: MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSSWLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNFLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MPSPQLLVLF -----CCCCEEEEEE	24.79	24043423
12	Phosphorylation	QLLVLFGSQTGTAQD EEEEEECCCCCCHHH	19.75	24043423
14	Phosphorylation	LVLFGSQTGTAQDVS EEEECCCCCCHHHHH	37.89	24043423
16	Phosphorylation	LFGSQTGTAQDVSER EECCCCCCHHHHHHH	25.24	24043423
21	Phosphorylation	TGTAQDVSERLGREA CCCHHHHHHHHHHHH	25.86	24043423
43	Phosphorylation	RVQALDSYPVVNLIN CCEECCCCCCHHCCC	10.34	25332170
60	Phosphorylation	LVIFVCATTGQGDPP EEEEEEECCCCCCCC	26.74	25332170
61	Phosphorylation	VIFVCATTGQGDPPD EEEEEECCCCCCCCC	14.69	25332170
138	Ubiquitination	DDQHELGPDAAVDPW CCCCCCCCCHHCCHH	40.46	21963094
173	Ubiquitination	IPPGVPLPSKFTLLF CCCCCCCCCCEEEEE	29.42	21963094
174	Phosphorylation	PPGVPLPSKFTLLFL CCCCCCCCCEEEEEE	48.35	24719451
207	Ubiquitination	QEPPSESKPFLAPMI CCCCCCCCCCCHHHC	35.42	-
207	Ubiquitination	QEPPSESKPFLAPMI CCCCCCCCCCCHHHC	35.42	21963094
220	Phosphorylation	MISNQRVTGPSHFQD HCCCCCCCCCCCCCC	45.63	-
284	O-linked_Glycosylation	QPREPDVSSPTRLPQ CCCCCCCCCCCCCCC	37.67	30379171
285	O-linked_Glycosylation	PREPDVSSPTRLPQP CCCCCCCCCCCCCCC	30.09	30379171
307	Phosphorylation	SHYLDIASVPRRSFF HHHHCHHCCCHHHHH	32.75	24719451
329	Ubiquitination	LHELEREKLLEFSSA HHHHHHHHHHHHHCC	65.67	-
329	Ubiquitination	LHELEREKLLEFSSA HHHHHHHHHHHHHCC	65.67	-
499 (in isoform 3)	Phosphorylation	-	12.19	24719451
499	Phosphorylation	DFYWEAEWQELEKRD CCEEHHHHHHHHHCC	12.19	24719451
510 (in isoform 3)	Phosphorylation	-	2.59	24719451
510	Phosphorylation	EKRDCLTLIPAFSRE HHCCCEEEEECCCHH	2.59	24719451
512 (in isoform 3)	Phosphorylation	-	30.30	24719451
512	Phosphorylation	RDCLTLIPAFSREQE CCCEEEEECCCHHHH	30.30	24719451
514	Ubiquitination	CLTLIPAFSREQEQK CEEEEECCCHHHHHH	6.24	-
517 (in isoform 3)	Phosphorylation	-	58.22	24719451
517	Phosphorylation	LIPAFSREQEQKVYV EEECCCHHHHHHHHH	58.22	24719451
518 (in isoform 3)	Phosphorylation	-	58.26	24719451
518	Phosphorylation	IPAFSREQEQKVYVQ EECCCHHHHHHHHHH	58.26	24719451
521	Ubiquitination	FSREQEQKVYVQHRL CCHHHHHHHHHHHHH	34.48	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO2	Q9UK22	PMID:24658274

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDOR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDOR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RNH2A_HUMAN	RNASEH2A	physical	22939629
SKIV2_HUMAN	SKIV2L	physical	22939629
SETD3_HUMAN	SETD3	physical	22939629
NDOR1_HUMAN	NDOR1	physical	20802492
CPIN1_HUMAN	CIAPIN1	physical	25416956
CCD33_HUMAN	CCDC33	physical	25416956
EFHC2_HUMAN	EFHC2	physical	25416956
TCHP_HUMAN	TCHP	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.