BHA15_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BHA15_HUMAN
• UniProt AC: Q7RTS1
• Protein Name: Class A basic helix-loop-helix protein 15
• Gene Name: BHLHA15
• Organism: Homo sapiens (Human).
• Sequence Length: 189
• Subcellular Localization: Nucleus .
• Protein Description: Plays a role in controlling the transcriptional activity of MYOD1, ensuring that expanding myoblast populations remain undifferentiated. Repression may occur through muscle-specific E-box occupancy by homodimers. May also negatively regulate bHLH-mediated transcription through an N-terminal repressor domain. Serves as a key regulator of acinar cell function, stability, and identity. Also required for normal organelle localization in exocrine cells and for mitochondrial calcium ion transport. May function as a unique regulator of gene expression in several different embryonic and postnatal cell lineages. Binds to the E-box consensus sequence 5'-CANNTG-3' (By similarity)..
• Protein Sequence: MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRSRPARAAARAPGEGRRRRPGPSGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEAQPQGHLQRYSTQIHSFREGT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MKTKNRPPRR -----CCCCCCCCCC	32.05	-
17	Phosphorylation	RRAPVQDTEATPGEG CCCCCCCCCCCCCCC	15.49	30624053
20	Phosphorylation	PVQDTEATPGEGTPD CCCCCCCCCCCCCCC	26.12	30624053
25	Phosphorylation	EATPGEGTPDGSLPN CCCCCCCCCCCCCCC	17.57	26657352
29	Phosphorylation	GEGTPDGSLPNPGPE CCCCCCCCCCCCCCC	48.29	30624053
72	Phosphorylation	GPGGRRDSSIQRRLE CCCCCCCHHHHHHHH	27.77	24275569
125	Ubiquitination	TLAKNYIKSLTATIL HHHHHHHHHHHHHHH	29.11	-
126	Phosphorylation	LAKNYIKSLTATILT HHHHHHHHHHHHHHH	22.76	-
128	Phosphorylation	KNYIKSLTATILTMS HHHHHHHHHHHHHHC	28.92	-
135	Phosphorylation	TATILTMSSSRLPGL HHHHHHHCCCCCCCC	21.67	-
178	Phosphorylation	PQGHLQRYSTQIHSF CCHHHHHHHHHHHHH	11.78	25003641
180	Phosphorylation	GHLQRYSTQIHSFRE HHHHHHHHHHHHHCC	23.70	25003641
184	Phosphorylation	RYSTQIHSFREGT-- HHHHHHHHHCCCC--	27.85	25003641

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BHA15_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BHA15_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BHA15_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H12_HUMAN	HIST1H1C	physical	28514442
CHCH2_HUMAN	CHCHD2	physical	28514442
FAF1_HUMAN	FAF1	physical	28514442
RNF41_HUMAN	RNF41	physical	28514442
PHF10_HUMAN	PHF10	physical	28514442
C1QBP_HUMAN	C1QBP	physical	28514442
H1T_HUMAN	HIST1H1T	physical	28514442
RS27A_HUMAN	RPS27A	physical	28514442
BAG1_HUMAN	BAG1	physical	28514442
RBM23_HUMAN	RBM23	physical	28514442
PRD10_HUMAN	PRDM10	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
LS14B_HUMAN	LSM14B	physical	28514442
RL36L_HUMAN	RPL36AL	physical	28514442
ZN579_HUMAN	ZNF579	physical	28514442
YBOX1_HUMAN	YBX1	physical	28514442
ZCHC9_HUMAN	ZCCHC9	physical	28514442
RT29_HUMAN	DAP3	physical	28514442
ZFP91_HUMAN	ZFP91	physical	28514442
ZN638_HUMAN	ZNF638	physical	28514442
RS15_HUMAN	RPS15	physical	28514442
RLA0_HUMAN	RPLP0	physical	28514442
LBR_HUMAN	LBR	physical	28514442
RL3_HUMAN	RPL3	physical	28514442
RS17_HUMAN	RPS17	physical	28514442
NOL12_HUMAN	NOL12	physical	28514442
DHX57_HUMAN	DHX57	physical	28514442
RT31_HUMAN	MRPS31	physical	28514442
RS16_HUMAN	RPS16	physical	28514442
RS3_HUMAN	RPS3	physical	28514442
YBOX3_HUMAN	YBX3	physical	28514442
RL7A_HUMAN	RPL7A	physical	28514442
NOP16_HUMAN	NOP16	physical	28514442
RS3A_HUMAN	RPS3A	physical	28514442
SUV3_HUMAN	SUPV3L1	physical	28514442
GPN3_HUMAN	GPN3	physical	28514442
EI2BA_HUMAN	EIF2B1	physical	28514442
RT09_HUMAN	MRPS9	physical	28514442
LARP1_HUMAN	LARP1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.