NR1I3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NR1I3_MOUSE
• UniProt AC: O35627
• Protein Name: Nuclear receptor subfamily 1 group I member 3
• Gene Name: Nr1i3
• Organism: Mus musculus (Mouse).
• Sequence Length: 358
• Subcellular Localization: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Recruited to the cytoplasm by DNAJC7.
• Protein Description: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity)..
• Protein Sequence: MTAMLTLETMASEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQAQRRAEKASLQLNQQQKELVQILLGAHTRHVGPMFDQFVQFKPPAYLFMHHRPFQPRGPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTENFFCGPLCYKMEDAVHAGFQYEFLESILHFHKNLKGLHLQEPEYVLMAATALFSPDRPGVTQREEIDQLQEEMALILNNHIMEQQSRLQSRFLYAKLMGLLADLRSINNAYSYELQRLEELSAMTPLLGEICS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	LTLETMASEEEYGPR EEHHHHCCCHHHCCC	34.42	25266776
16	Phosphorylation	TMASEEEYGPRNCVV HHCCCHHHCCCCEEE	35.39	28576409
48	Phosphorylation	CKGFFRRTVSKTIGP CCHHHHHHHCCCCCC	25.52	22817900
51	Ubiquitination	FFRRTVSKTIGPICP HHHHHHCCCCCCCCC	39.56	22790023
111	Ubiquitination	QAQRRAEKASLQLNQ HHHHHHHHHHHHHHH	42.14	22790023
196	Phosphorylation	LPLFRSLTMEDQISL CCCHHCCCHHHHHHH	21.54	-
202	Phosphorylation	LTMEDQISLLKGAAV CCHHHHHHHHHHHHH	23.24	22817900
358	Phosphorylation	PLLGEICS------- HHHHHHCC-------	49.25	29514104

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
48	T	Phosphorylation	Kinase	PKC	-	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
48	T	Phosphorylation	Phosphorylated at Thr-48 by PKC, dephosphorylation of Thr-48 is required for nuclear translocation and activation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NR1I3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NR0B2_MOUSE	Nr0b2	physical	8650544
RXRG_MOUSE	Rxrg	physical	20211142
NCOA1_MOUSE	Ncoa1	physical	15610065
NCOR2_MOUSE	Ncor2	physical	15610065
PRS6B_MOUSE	Psmc4	physical	8603043
NR0B2_HUMAN	NR0B2	physical	14963109
HS90B_MOUSE	Hsp90ab1	physical	12885400
PP2AA_MOUSE	Ppp2ca	physical	12885400
2AAA_MOUSE	Ppp2r1a	physical	12885400
NCOR2_HUMAN	NCOR2	physical	16219912
SMC1A_HUMAN	SMC1A	physical	16623664

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.