RXRG_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RXRG_MOUSE
• UniProt AC: P28705
• Protein Name: Retinoic acid receptor RXR-gamma
• Gene Name: Rxrg
• Organism: Mus musculus (Mouse).
• Sequence Length: 463
• Subcellular Localization: Nucleus.
• Protein Description: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)..
• Protein Sequence: MYGNYSHFMKFPTGFGGSPGHTGSTSMSPSVALPTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECASSSHEDMPVERILEAELAVEPKTESYGDMNVENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDSFLMEMLETPLQIT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	Phosphorylation	FGGSPGHTGSTSMSP CCCCCCCCCCCCCCC	38.45	25293948
24	Phosphorylation	GSPGHTGSTSMSPSV CCCCCCCCCCCCCCE	20.61	25293948
25	Phosphorylation	SPGHTGSTSMSPSVA CCCCCCCCCCCCCEE	29.78	25293948
26	Phosphorylation	PGHTGSTSMSPSVAL CCCCCCCCCCCCEEC	20.96	25293948
28	Phosphorylation	HTGSTSMSPSVALPT CCCCCCCCCCEECCC	17.50	25293948
30	Phosphorylation	GSTSMSPSVALPTGK CCCCCCCCEECCCCC	16.83	25293948
35	Phosphorylation	SPSVALPTGKPMDSH CCCEECCCCCCCCCC	59.70	25293948
222	Phosphorylation	RSRERAESEAECASS HHHHHHHHHHHHHHC	40.91	23684622
382	Ubiquitination	VLFNPDAKGLSNPSE HHCCCCCCCCCCHHH	68.70	22790023
392	Phosphorylation	SNPSEVETLREKVYA CCHHHHHHHHHHHHH	35.97	21454597
418	Ubiquitination	EQPGRFAKLLLRLPA CCCCHHHHHHHHHHH	36.63	-
428	O-linked_Glycosylation	LRLPALRSIGLKCLE HHHHHHHHHHHHHHH	23.12	30059200

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RXRG_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RXRG_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RXRG_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
THB_MOUSE	Thrb	physical	20211142
NR1H3_MOUSE	Nr1h3	physical	20211142
NR1H2_MOUSE	Nr1h2	physical	20211142
PAWR_MOUSE	Pawr	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.