NR1H3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NR1H3_MOUSE
• UniProt AC: Q9Z0Y9
• Protein Name: Oxysterols receptor LXR-alpha
• Gene Name: Nr1h3
• Organism: Mus musculus (Mouse).
• Sequence Length: 445
• Subcellular Localization: Nucleus .
• Protein Description: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. [PubMed: 18055760]
• Protein Sequence: MSLWLEASMPDVSPDSATELWKTEPQDAGDQGGNTCILREEARMPQSTGVALGIGLESAEPTALLPRAETLPEPTELRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGARYVCHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAQATSVSPRVSSPPQVLPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPIAPDPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSINHPHDPLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
188	Phosphorylation	EEEQAQATSVSPRVS HHHHHHCCCCCCCCC	19.99	23984901
189	Phosphorylation	EEQAQATSVSPRVSS HHHHHCCCCCCCCCC	24.50	23984901
191	Phosphorylation	QAQATSVSPRVSSPP HHHCCCCCCCCCCCC	13.52	25521595
195	Phosphorylation	TSVSPRVSSPPQVLP CCCCCCCCCCCCCCC	38.11	26643407
196	Phosphorylation	SVSPRVSSPPQVLPQ CCCCCCCCCCCCCCC	37.43	26643407
205	Phosphorylation	PQVLPQLSPEQLGMI CCCCCCCCHHHHHHH	22.57	23140645
290	Phosphorylation	DQIALLKTSAIEVML HHHHHHHCHHHHHHH	24.30	22817900
291	Phosphorylation	QIALLKTSAIEVMLL HHHHHHCHHHHHHHH	26.17	22817900
432	Acetylation	ALRLQDKKLPPLLSE HHHCCCCCCCCHHHH	74.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
195	S	Phosphorylation	Kinase	PKACA	P17612	PSP
196	S	Phosphorylation	Kinase	PKACA	P17612	PSP
290	T	Phosphorylation	Kinase	PKACA	P17612	PSP
291	S	Phosphorylation	Kinase	PKACA	P17612	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NR1H3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NR1H3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRGC2_MOUSE	Ppargc1b	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.