PRGC2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRGC2_MOUSE
• UniProt AC: Q8VHJ7
• Protein Name: Peroxisome proliferator-activated receptor gamma coactivator 1-beta
• Gene Name: Ppargc1b
• Organism: Mus musculus (Mouse).
• Sequence Length: 1014
• Subcellular Localization: Nucleus.
• Protein Description: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner..
• Protein Sequence: MAGNDCGALLDEELSSFFLNYLSDTQGGDSGEEQLCADLPELDLSQLDASDFDSATCFGELQWCPETSETEPSQYSPDDSELFQIDSENEALLAALTKTLDDIPEDDVGLAAFPELDEGDTPSCTPASPAPLSAPPSPTLERLLSPASDVDELSLLQKLLLATSSPTASSDALKDGATWSQTSLSSRSQRPCVKVDGTQDKKTPTLRAQSRPCTELHKHLTSVLPCPRVKACSPTPHPSPRLLSKEEEEEVGEDCPSPWPTPASPQDSLAQDTASPDSAQPPEEDVRAMVQLIRYMHTYCLPQRKLPQRAPEPIPQACSSLSRQVQPRSRHPPKAFWTEFSILRELLAQDILCDVSKPYRLAIPVYASLTPQSRPRPPKDSQASPAHSAMAEEVRITASPKSTGPRPSLRPLRLEVKRDVNKPTRQKREEDEEEEEEEEEEEEEKEEEEEEWGRKRPGRGLPWTKLGRKMDSSVCPVRRSRRLNPELGPWLTFTDEPLGALPSMCLDTETHNLEEDLGSLTDSSQGRQLPQGSQIPALESPCESGCGDTDEDPSCPQPTSRDSSRCLMLALSQSDSLGKKSFEESLTVELCGTAGLTPPTTPPYKPMEEDPFKPDTKLSPGQDTAPSLPSPEALPLTATPGASHKLPKRHPERSELLSHLQHATTQPVSQAGQKRPFSCSFGDHDYCQVLRPEAALQRKVLRSWEPIGVHLEDLAQQGAPLPTETKAPRREANQNCDPTHKDSMQLRDHEIRASLTKHFGLLETALEGEDLASCKSPEYDTVFEDSSSSSGESSFLLEEEEEEEEGGEEDDEGEDSGVSPPCSDHCPYQSPPSKASRQLCSRSRSSSGSSSCSSWSPATRKNFRRESRGPCSDGTPSVRHARKRREKAIGEGRVVYIRNLSSDMSSRELKKRFEVFGEIVECQVLTRSKRGQKHGFITFRCSEHAALSVRNGATLRKRNEPSFHLSYGGLRHFRWPRYTDYDPTSEESLPSSGKSKYEAMDFDSLLKEAQQSLH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3 (in isoform 2)	Phosphorylation	-	42.22	26643407
4 (in isoform 2)	Phosphorylation	-	48.75	26643407
7 (in isoform 2)	Phosphorylation	-	23.32	26643407
8 (in isoform 2)	Phosphorylation	-	15.98	26643407
9 (in isoform 2)	Phosphorylation	-	3.62	26643407
10 (in isoform 2)	Phosphorylation	-	8.47	19367708
12 (in isoform 2)	Phosphorylation	-	61.89	26643407
14 (in isoform 2)	Phosphorylation	-	4.97	26643407
145	Phosphorylation	PTLERLLSPASDVDE CHHHHHCCCCCCHHH	24.02	21743459
148	Phosphorylation	ERLLSPASDVDELSL HHHCCCCCCHHHHHH	41.36	21743459
154	Phosphorylation	ASDVDELSLLQKLLL CCCHHHHHHHHHHHH	25.61	28066266
163	Phosphorylation	LQKLLLATSSPTASS HHHHHHHCCCCCCCC	29.70	28066266
164	Phosphorylation	QKLLLATSSPTASSD HHHHHHCCCCCCCCH	28.81	28066266
165	Phosphorylation	KLLLATSSPTASSDA HHHHHCCCCCCCCHH	23.16	25266776
167	Phosphorylation	LLATSSPTASSDALK HHHCCCCCCCCHHHH	40.91	28066266
169	Phosphorylation	ATSSPTASSDALKDG HCCCCCCCCHHHHCC	31.09	28066266
170	Phosphorylation	TSSPTASSDALKDGA CCCCCCCCHHHHCCC	25.16	28066266
202	Acetylation	VDGTQDKKTPTLRAQ ECCCCCCCCCCHHHC	68.94	19491097
218	Acetylation	RPCTELHKHLTSVLP CCCHHHHHHHHHCCC	53.59	19491097
230	Acetylation	VLPCPRVKACSPTPH CCCCCCCCCCCCCCC	44.98	19491097
329	Phosphorylation	SRQVQPRSRHPPKAF HHHCCCCCCCCCCHH	41.44	21743459
384	Phosphorylation	PPKDSQASPAHSAMA CCCCCCCCHHHHHHH	18.25	23684622
455	Acetylation	EEEEWGRKRPGRGLP HHHHHHHCCCCCCCC	60.03	19491097
469	Acetylation	PWTKLGRKMDSSVCP CCHHHCCCCCCCCCC	45.31	19491097
519	Phosphorylation	NLEEDLGSLTDSSQG CHHHHHHHCCCCCCC	35.08	-
630	Phosphorylation	DTAPSLPSPEALPLT CCCCCCCCCCCCCCC	40.44	-
645	Acetylation	ATPGASHKLPKRHPE CCCCCCCCCCCCCHH	65.08	19491097
674	Acetylation	PVSQAGQKRPFSCSF CCHHCCCCCCCCCCC	62.21	19491097
703	Phosphorylation	LQRKVLRSWEPIGVH HHHHHHHHCCCCEEE	31.46	26060331
726	Acetylation	APLPTETKAPRREAN CCCCCCCCCCHHHHH	50.60	19491097
739	Phosphorylation	ANQNCDPTHKDSMQL HHCCCCCCCHHHHHH	28.45	28059163
754	Phosphorylation	RDHEIRASLTKHFGL HHHHHHHHHHHHHCH	27.07	-
896	Phosphorylation	IGEGRVVYIRNLSSD HCCCCEEEEEECCCC	7.42	24719451
905	Phosphorylation	RNLSSDMSSRELKKR EECCCCCCHHHHHHH	31.10	25338131
933	Acetylation	TRSKRGQKHGFITFR ECCCCCCEEEEEEEE	48.82	19491097
962	Phosphorylation	LRKRNEPSFHLSYGG HHCCCCCCEECCCCC	21.08	-
966	Phosphorylation	NEPSFHLSYGGLRHF CCCCEECCCCCCCCC	17.11	-
967	Phosphorylation	EPSFHLSYGGLRHFR CCCEECCCCCCCCCC	22.90	-
981	Phosphorylation	RWPRYTDYDPTSEES CCCCCCCCCCCCCCC	18.93	29895711
984	Phosphorylation	RYTDYDPTSEESLPS CCCCCCCCCCCCCCC	45.96	29895711
985	Phosphorylation	YTDYDPTSEESLPSS CCCCCCCCCCCCCCC	44.76	29895711
991	Phosphorylation	TSEESLPSSGKSKYE CCCCCCCCCCCCHHH	57.95	29895711
992	Phosphorylation	SEESLPSSGKSKYEA CCCCCCCCCCCHHHH	48.58	29895711
994	Acetylation	ESLPSSGKSKYEAMD CCCCCCCCCHHHHCC	45.80	19491097

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRGC2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRGC2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRGC2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PRGC2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.