NR1H2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NR1H2_MOUSE
• UniProt AC: Q60644
• Protein Name: Oxysterols receptor LXR-beta
• Gene Name: Nr1h2
• Organism: Mus musculus (Mouse).
• Sequence Length: 446
• Subcellular Localization: Nucleus .
• Protein Description: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. [PubMed: 18055760]
• Protein Sequence: MSSPTSSLDTPVPGNGSPQPSTSATSPTIKEEGQETDPPPGSEGSSSAYIVVILEPEDEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKEAGMREQCVLSEEQIRKKRIQKQQQQQPPPPSEPAASSSGRPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPSRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MSSPTSSLDTPV ---CCCCCCCCCCCC	32.66	25338131
17	Phosphorylation	TPVPGNGSPQPSTSA CCCCCCCCCCCCCCC	25.10	25338131
23	Phosphorylation	GSPQPSTSATSPTIK CCCCCCCCCCCCCCC	33.61	25338131
25	Phosphorylation	PQPSTSATSPTIKEE CCCCCCCCCCCCCCC	34.70	25338131
433	Acetylation	ALRLQDKKLPPLLSE HHHCCCCCCCCHHHH	74.62	17936707

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NR1H2_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
395	K	Sumoylation	Sumoylated by SUMO2 at Lys-395 and Lys-433 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.	-
433	K	Sumoylation	Sumoylated by SUMO2 at Lys-395 and Lys-433 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NR1H2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NR1H2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.