MEI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEI1_HUMAN
• UniProt AC: Q5TIA1
• Protein Name: Meiosis inhibitor protein 1
• Gene Name: MEI1 {ECO:0000312|HGNC:HGNC:28613}
• Organism: Homo sapiens (Human).
• Sequence Length: 1274
• Protein Description: Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)..
• Protein Sequence: MAVRQAATAGTPGPRREEEAALLFERAHYRHDPRWLLPVTPRLCLACALELLPDPGVSLVRKKHMLSCFQDALVRHTSLVTQLVSQDQRVCIHFISVLFGLLCSMEDGSVTDLCIEVLIQITTQLKLEQTIRCLLDECHKELCNMPSMRGSLATLTLLGKLVDAIPALADELVMEHGNLMEHLLRGLVYPSEGIQASVCYLYGKLYSSPVAAEMLSGHFREKLFPLFLSILDGAQTKELQINCLGLLRQLLKYDLFVSMIMNQDGLGESAKNIEGSSGNTSLPLVLKKLLLSRDETLQVASAHCITAVLVHSPAKHASAFIHADIPEFLFEHLSSSSEVLVWSSCNCLTLLVEEPLFFSKCHTVYGIEAVVRSLQGSLKMNNIELHKQGLLLFAEILTRQPEEIKLFTSSAMCRDAGRALQEAVSSPVLEVAAEALKATSAFLRKDHQSTPPVQYGELQALLEAMLNRCAEFSQTLLSRRPLGHASSRDSEKAILQRGKFLLSTLEGFRSACRLAIEFQSEPSAQENPFTAPSAKKEDTLEAFSEFLLSACDSLCIPMVMRHLEQTTHPALMEVFLSILHNLFVIVPHMKEKFSKKLASSSFIRLTLELKARFCSGLSHSALNQVCSNFLYYMCLNLLSAPEKTGPPSKEELSAVSELLQHGLPQISSRSPESLAFLSDRQYMEGAARQRQYCILLLFYLAYIHEDRFVSEAELFEAVQSFLLSLQDQGERPPLVVFKASIYLLAICQDKDNTLRETMVSAIRKFLEGIPDLQLVYTHHPLLLRFFLLYPELMSRYGHRVLELWFFWEESSYEELDDVTSAGQPALPASLVVLFQLLRSIPSILLILLDLIYSSPVDTAHKVLISLRTFLRRNEDIQVGGLIRGHFLLILQRLLVEHGASPSGASGNLPLLLSLLSLMQLRNVSEQELDSVAMKLLHQVSKLCGKCSPTDVDILQPSFNFLYWSLHQTTPSSQKRAAAVLLSSTGLMELLEKMLALTLAKADSPRTALLCSAWLLTASFSAQQHKGSLQVHQTLSVEMDQVLKALSFPKKKAALLSAAILCFLRTALRQSFSSALVALVPSGAQPLPATKDTVLAPLRMSQVRSLVIGLQNLLVQKDPLLSQACVGCLEALLDYLDARSPDIALHVASQPWNRFLLFTLLDAGENSFLRPEILRLMTLFMRYRSSSVLSHEEVGDVLQGVALADLSTLSNTTLQALHGFFQQLQSMGHLADHSMAQTLQASLEGLPPSTSSGQPPLQDMLCLGGVAVSLSHIRN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
280	Phosphorylation	IEGSSGNTSLPLVLK CCCCCCCCCHHHHHH	34.86	-
449	Phosphorylation	FLRKDHQSTPPVQYG HHCCCCCCCCCCCHH	39.19	22210691
450	Phosphorylation	LRKDHQSTPPVQYGE HCCCCCCCCCCCHHH	25.66	22210691
455	Phosphorylation	QSTPPVQYGELQALL CCCCCCCHHHHHHHH	16.89	22210691
594	Phosphorylation	PHMKEKFSKKLASSS HHHHHHHHHHHHCCC	39.69	-
601	Phosphorylation	SKKLASSSFIRLTLE HHHHHCCCHHHHHHH	23.38	24719451
760	O-linked_Glycosylation	TLRETMVSAIRKFLE HHHHHHHHHHHHHHC	13.73	30379171
902	Phosphorylation	VEHGASPSGASGNLP HHCCCCCCCCCCCHH	44.49	-
913	Phosphorylation	GNLPLLLSLLSLMQL CCHHHHHHHHHHHHH	27.51	-
982	Phosphorylation	RAAAVLLSSTGLMEL HHHHHHHCCCCHHHH	22.99	26074081
983	Phosphorylation	AAAVLLSSTGLMELL HHHHHHCCCCHHHHH	26.85	26074081
984	Phosphorylation	AAVLLSSTGLMELLE HHHHHCCCCHHHHHH	30.84	26074081
997	Phosphorylation	LEKMLALTLAKADSP HHHHHHHHHHCCCCH	21.04	-
1003	Phosphorylation	LTLAKADSPRTALLC HHHHCCCCHHHHHHH	22.57	-
1092	Phosphorylation	PLPATKDTVLAPLRM CCCCCCCCCHHHCCH	20.98	22985185

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEI1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEI1_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MEI1_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.