CSN9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSN9_HUMAN
• UniProt AC: Q8WXC6
• Protein Name: COP9 signalosome complex subunit 9 {ECO:0000305}
• Gene Name: COPS9 {ECO:0000312|HGNC:HGNC:21314}
• Organism: Homo sapiens (Human).
• Sequence Length: 57
• Subcellular Localization: Isoform 1: Nucleus . Cytoplasm . Nucleus, nucleoplasm . Excluded from the nucleolus. Recruited to the nucleoplasm and chromatin following DNA damage induction.; Isoform 2: Nucleus, nucleoplasm . Excluded from the nucleolus.
• Protein Description: Isoform 1: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation.; Isoform 2: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11..
• Protein Sequence: MKPAVDEMFPEGAGPYVDLDEAGGSTGLLMDLAANEKAVHADFFNDFEDLFDDDDIQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Ubiquitination	------MKPAVDEMF ------CCCCHHHHC		-
14 (in isoform 1)	Phosphorylation	-		28348404
16	Phosphorylation	FPEGAGPYVDLDEAG CCCCCCCCCCHHHCC		27642862
25	Phosphorylation	DLDEAGGSTGLLMDL CHHHCCCCCCHHHHH		24275569
26	Phosphorylation	LDEAGGSTGLLMDLA HHHCCCCCCHHHHHH		26456823
52 (in isoform 1)	Phosphorylation	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSN9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSN9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSN9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSN5_HUMAN	COPS5	physical	23776465
CUL1_HUMAN	CUL1	physical	23776465
CUL3_HUMAN	CUL3	physical	23776465
RL11_HUMAN	RPL11	physical	23776465
CSN1_HUMAN	GPS1	physical	26456823
CSN3_HUMAN	COPS3	physical	26456823
CSN5_HUMAN	COPS5	physical	26456823
CSN8_HUMAN	COPS8	physical	26456823
CSN6_HUMAN	COPS6	physical	26456823

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.