SSH_DROME - dbPTM
SSH_DROME - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SSH_DROME
UniProt AC Q6NN85
Protein Name Protein phosphatase Slingshot
Gene Name ssh
Organism Drosophila melanogaster (Fruit fly).
Sequence Length 1045
Subcellular Localization Cytoplasm, cytoskeleton.
Protein Description Protein phosphatase which regulates actin filament dynamics. [PubMed: 11832213]
Protein Sequence MALVTVQRSPSVAGSCSNSDGESEDDEGNSKGNDRSECFFAGKGTALVLALKDIPPLTQSERRLSTDSTRSSNSTQSNNSDIQLHLQSMFYLLQREDTLKMAVKLESQRSNRTRYLVIASRSCCRSGTSDRRRHRIMRHHSVKVGGSAGTKSSTSPAVPTQRQLSVEQTATEASSKCDKTADKENATAAGDNKNTSGMEESCLLGIDCNERTTIGLVVPILADTTIHLDGDGGFSVKVYEKTHIFKPVSVQAMWSALQTLHKVSKKARENNFYASGPSHDWLSSYERRIESDQSCLNEWNAMDALESRRPPSPDAIRNKPPEKEETESVIKMKLKAIMMSVDLDEVTSKYIRGRLEEILDMDLGEYKSFIDAEMLVILGQMDAPTKIFEHVYLGSEWNASNLEELQKNGVRHILNVTREIDNFFPGTFEYFNVRVYDDEKTNLLKYWDDTFRYITRAKAEGSKVLVHCKMGVSRSASVVIAYAMKAYQWEFQQALEHVKKRRSCIKPNKNFLNQLETYSGMLDAMKNKEKLQRSKSETNLKSTKDARLLPGSEPTPLIQALNQAKSKSTGEAGVTPDGEEEDGSRMHRRSIAQKSQRRMVRRSSSTSPKTQTAVVTKQQSQSMENLTPERSVAEEPKNMRFPGSNGENYSVTQNQVLHIQKHTPLSVRTRIHDLEAHRADQLPQQPVWTSLTKLITQTSHLGKSVSGSSSGNIDSRRDSSCSDVFSSQVDSVFAKDEGEKRQRRKTHSWTESLGPSGGIVLDPTPQQQKQQSNAILRPRGTRQRELPSRHASWGSGDNRCCLPQRTSSGSYYDSNRNTTAIFEGVIQDLKRSSNCNVIEGVAVAVEPIVGVGEGTVKRTKQKLEESTSLKKRCQEESQELLLEAVDAGQRRCPSLYRSASSAHSPRQRQPLRCNSEELMHTSDIENKNTTPGDHEATVVLRVQGQTLADDQRISGNVQILKQNFEAKAGVVGTGGGGGGGTAAGSGSSSTIATSVSAVAGACSANPGKKTTSHQSLPSSPVAQHANHVSAASNSNSSASNSSDSS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
65PhosphorylationTQSERRLSTDSTRSS
CHHHHHHCCCCCCCC		28.4919429919
66PhosphorylationQSERRLSTDSTRSSN
HHHHHHCCCCCCCCC		38.2619429919
68PhosphorylationERRLSTDSTRSSNST
HHHHCCCCCCCCCCC		26.3029892262
165PhosphorylationVPTQRQLSVEQTATE
CCCHHEEEHHHHHHH		18.4421082442
312PhosphorylationLESRRPPSPDAIRNK
HHHCCCCCCHHHHCC		37.7919429919
536PhosphorylationEKLQRSKSETNLKST
HHHHHCCCCCCCCCC		51.4027626673
622PhosphorylationVTKQQSQSMENLTPE
EEHHHHHHHHHCCCC		33.0525749252
689PhosphorylationLPQQPVWTSLTKLIT
CCCCCHHHHHHHHHH		17.6921082442
690PhosphorylationPQQPVWTSLTKLITQ
CCCCHHHHHHHHHHH		20.5221082442
692PhosphorylationQPVWTSLTKLITQTS
CCHHHHHHHHHHHCC		24.4621082442
698PhosphorylationLTKLITQTSHLGKSV
HHHHHHHCCCCCCCC		14.9521082442
699PhosphorylationTKLITQTSHLGKSVS
HHHHHHCCCCCCCCC		13.5921082442
719PhosphorylationNIDSRRDSSCSDVFS
CCCCCCCCCHHHHHH		31.2811832213
746PhosphorylationEKRQRRKTHSWTESL
CHHHHHHHCCCHHHH		21.2321082442
748PhosphorylationRQRRKTHSWTESLGP
HHHHHHCCCHHHHCC		40.7121082442
750PhosphorylationRRKTHSWTESLGPSG
HHHHCCCHHHHCCCC		20.7921082442
752PhosphorylationKTHSWTESLGPSGGI
HHCCCHHHHCCCCCE		31.1121082442
792PhosphorylationELPSRHASWGSGDNR
CCCCCCCCCCCCCCC		26.3319429919
806PhosphorylationRCCLPQRTSSGSYYD
CCCCCCCCCCCCEEC		23.2327626673
832PhosphorylationVIQDLKRSSNCNVIE
HHHHHHHCCCCCEEE		25.0621082442
833PhosphorylationIQDLKRSSNCNVIEG
HHHHHHCCCCCEEEC		49.8121082442
855PhosphorylationIVGVGEGTVKRTKQK
ECCCCCHHHHHHHHH		20.6721082442
904PhosphorylationRSASSAHSPRQRQPL
HCCCCCCCCCCCCCC		22.8419429919
915PhosphorylationRQPLRCNSEELMHTS
CCCCCCCHHHHHCHH		35.7521082442
954PhosphorylationLADDQRISGNVQILK
CCCCCEECCCCHHHH		26.8929892262
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SSH_DROME !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SSH_DROME !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SSH_DROME !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
LIMK1_DROMELIMK1genetic
11832213
CDC42_DROMECdc42genetic
15572110
RHO1_DROMERho1genetic
15572110
CADF_DROMEtsrgenetic
15572110
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SSH_DROME

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-719, AND MASSSPECTROMETRY.

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