BOSS_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BOSS_DROME
• UniProt AC: P22815
• Protein Name: Protein bride of sevenless
• Gene Name: boss
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 896
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein .
• Protein Description: Acts as a ligand for sevenless tyrosine-kinase receptor during eye development..
• Protein Sequence: MKVMDALQSGRRKPLPVALLCILVTVFCVLECHGADLTSPTKKSAPLRITKPQPTSQQAKPISITTRAPTTVASTTDDEVSSSVDGQLAPLISSTTEGPSSGTTASLVPEICLNGLQLTVNSADEGTVIRKQEEFVKILEGDVVLSVLTKDPDSALFVINRVNQANLIMADFEIGIRAISIDNASLAENLLIQEVQFLQQCTTYSMGIFVDWELYKQLESVIKDLEYNIWPIPGTRAHLFPKVAHLLHQMPWGEKIASVEIATETLEMYNEFMEAARQEHMCLMHFKSDDNVYIMFGNKLASHFKENGTLFSVPTDRTDDEFLADLPNRAFVLMENEIDLSTAVELDATPTALDEILIGKSVLPSRVLSFAGSIIDLMNWLRGSLSKHCKRGEEHDLYVLESCFNFLNFIEDWRTSEYRQAHDTAEILSLLLMRKLGTAMNFQMYQKKVLTLDKITGESRTELREIASQNFVTNVTTYYHYNRDNHTSLELKTKFGQVFNCQYSAGDNRRYPFLFDGESVMFWRIKMDTWVATGLTAAILGLIATLAILVFIVVRISLGDVFEGNPTTSILLLLSLILVFCSFVPYSIEYVGEQRNSHVTFEDAQTLNTLCAVRVFIMTLVYCFVFSLLLCRAVMLASIGSEGGFLSHVNGYIQAVICAFSVVAQVGMSVQLLVVMHVASETVSCENIYYGRWLWGLLAYDFALLCCVGALIPSIYRSQRNYREGILIVIGSVLIMVIWVAWIALSLFGDEWRDAAIPLGLQASGWAVLVGILIPRTFLIVRGIERSDIAQALPSLTSLAFAQNNQYSSEQSVYECVNPAMRHCSQDEVNHQSPSEIPTLPLRGGGPRRQQFFANLRQANANINPQRPPPRPQQSPSRSSVSSLPPSPDHNKITRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
183	N-linked_Glycosylation	IRAISIDNASLAENL EEEEECCCHHHHHHH	29.74	-
307	N-linked_Glycosylation	LASHFKENGTLFSVP HHHHHHHCCEEEECC	49.71	-
474	N-linked_Glycosylation	ASQNFVTNVTTYYHY HHCCCCEEEEEEEEE	24.68	-
485	N-linked_Glycosylation	YYHYNRDNHTSLELK EEEECCCCCCEEEEE	36.78	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BOSS_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BOSS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BOSS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
7LESS_DROME	sev	physical	1857416
GAP1_DROME	RasGAP1	genetic	1547500

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.