VAV_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VAV_DROME
• UniProt AC: Q9NHV9
• Protein Name: Protein vav
• Gene Name: Vav
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 793
• Protein Description: Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases. Probably plays a pivotal role as a signal transducer protein during fruit fly development..
• Protein Sequence: MASSSSSNSFGGVAGVNGDLWRECVAWLTRCKVIPPDHKAAQPDAEIRILAMTLRDGVLLCNLVIHLDPSSLDPREFNRKPQMAQFLCSKNIKLFLDVCHNNFGIRDADLFEPTMLYDLTNFHRVLITLSKLSQCRKVQQLHPDLIGFNLQLSPTERSHSDEAIYKDLHSTTTDNIACNGTGYDHTNTKEEEVYQDLCALHRTSRSQTASSTSFEQRDYVIRELIDTESNYLDVLTALKTKFMGPLERHLNQDELRLIFPRIRELVDIHTKFLDKLRESLTPNAKVKMAQVFLDFREPFLIYGEFCSLLLGAIDYLADVCKKNQIIDQLVQKCERDYNVGKLQLRDILSVPMQRILKYHLLLDKLVKETSPLHDDYRSLERAKEAMIDVSQYINEVKRDSDHLVIIQKVKDSICDIHLLQNGNGSDLLQYGRLLLDGELHIKAHEDQKTKLRYAFVFDKILIMVKALHIKTGDMQYTYRDSHNLADYRVEQSHSRRTIGRDTRFKYQLLLARKSGKTAFTLYLKSEHERDKWRKALTEAMESLEPPGCQSTDHKMEIYTFDAPTTCRHCSKFLKGRIHQGYRCKVCQISVHKGCISSTGRCKQNPVSVPPPVCDRQLSEFNWFAGNMDRETAAHRLENRRIGTYLLRVRPQGPSTAHETMYALSLKTDDNVIKHMKINQENSGDSMLYCLSSRRHFKTIVELVSYYERNDLGENFAGLNQSLQWPYKEVIATALYDYEPKAGSNQLQLRTDCQVLVIGKDGDSKGWWRGKIGDTVGYFPKEYVQEQKLASEEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
153	Phosphorylation	IGFNLQLSPTERSHS HEEECCCCCCCCCCC	19.47	21082442
158	Phosphorylation	QLSPTERSHSDEAIY CCCCCCCCCCCHHHH	22.55	19429919
160	Phosphorylation	SPTERSHSDEAIYKD CCCCCCCCCHHHHHH	38.09	19429919
171	Phosphorylation	IYKDLHSTTTDNIAC HHHHHHCCCCCCEEE	23.98	22668510
181	Phosphorylation	DNIACNGTGYDHTNT CCEEECCCCCCCCCC	20.69	19429919
183	Phosphorylation	IACNGTGYDHTNTKE EEECCCCCCCCCCCH	12.37	19429919
186	Phosphorylation	NGTGYDHTNTKEEEV CCCCCCCCCCCHHHH	41.50	19429919
188	Phosphorylation	TGYDHTNTKEEEVYQ CCCCCCCCCHHHHHH	40.77	19429919

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VAV_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VAV_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VAV_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SOS_DROME	Sos	genetic	20147552
SPITZ_DROME	spi	genetic	25813543
CADE_DROME	shg	genetic	25813543
RAC2_DROME	Rac2	genetic	20147552

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.