dbPTM

RHDF1_DROME - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RHDF1_DROME
UniProt AC	Q76NQ1
Protein Name	Inactive rhomboid protein 1
Gene Name	rho-5
Organism	Drosophila melanogaster (Fruit fly).
Sequence Length	1429
Subcellular Localization	Endoplasmic reticulum membrane Multi-pass membrane protein .
Protein Description	Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration..
Protein Sequence	MSSNGSDLGHNNRRNEKGNPDSVHSSMRGSMSSTRRKSINFQNQLQLALESNECDVMYCSLSSGRFRAPNGENFPPHGGKLKLSPLEKYDDANRGVPPPSPAPNSDCFATCVANQLPSQSCSVGSAKPETSVMQKHGMAGNGMVGSGMSGNGMAANGTNYHQRGVSPNSRYRLERYRESQSTPQSKLMDNMGGMPSAVPSVSATRLLLPSNVPLPLAQCENYNAYLGSTVHTPVKRYVPTPPPAMELYSDLSISSSPAANLPTPAAAVASSASTSASAMQSQYANMPYNYRSKCCHSEASHGSLSRTSQTYASCSPACTSPSPAPSTSMSMVFSAASSCSPIMTATSSARSGNHRGDDSDSVIVVPPGGGAMAQIEAENPSGTCLHCNTVRRTTGVHQTTQTTGPISPVPISLPVPMAMPVMSGLNEQMPSQSLESSMVSVQAKRLEGGGNMAVPPGSNQHQLYRSQMASNPRLQHIHHQTQQHQSLQVLPQPQNHHLSCKKRIGMYMRRTTSQFFGVEPSTEAADCALWQGRHRRLAIRCFGMFDTELEYHMQQAIGGGNEDAGQSNGTNGNYAPDRPDILPVQDAIGMDMTMSGDSRRQKCYTNRDFLAGEFVERKASVGYMFVAMVSYLVHMFNKRRPIQMHRVRCPWQWSRSFAPIHVQSHSNQQTDADGCLTDGLEAIIDDEVFFDSPCEITTSAVNDESSDIGRQAAKPRPCADQSGVGVSVYMAERQQNGWRTSALNSGGNATSDINLTGDQSSHQPGAAHIPLCSSVSSQMQPAMRSSHSTTSTCNRGNRITAQLLDGVLENSRRPPLRCIKYFSVNDLDDRTDHRPFFTYWINTVQVVVLILSIICYGIAPIGIGSEQKTGQVLVTSLSLQTVQHVEQRNLWIGPRNIDLVHMGAKFAACMRRDIKITEVVTKTRRHERETACCIRNDDSGCVQSSQAECSIRGLYPTKSISTWKKWSPSESGPGGRISGSVCGLDPKFCDAPASIAPYEWPDDITKWPICRKTNSFTQRYRYKDHTSEHMVCEVIGHPCCTGLYGECRITTREYCDFIKGYFHEEASLCSQISCLNNVCGMFPFISVETPDQLYRLLTSLCMHAGILHLAITLIFQHLFLADLERLIGTVRTAIVYIMSGFAGNLTSAILVPHRPEVGPSASLSGVVASLIALLVWMHWKYLHKPHIALFKLLLLCSVLVGIGTLPYQLNFLGLLAGVICGCLLTMSLVPFTTFSKYGRKKKINLIWTCVLFHVVVYTAMIVTFYIHPSEFHSISFVDMFSNSNGYDNFTNADHHGVDVVSSNTRYSQTQNSQYYYHHHSDDIIRKSVTFTEKALVSHILYPTAPRKTSAQQWQEVEYSRSFNHLSNYSDRIKKSIGNISKLKQVFTSPIRFSNKNNHSNLMTELTSVHSENKQKYLGYINNNTEFNVL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of RHDF1_DROME !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RHDF1_DROME !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RHDF1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RHDF1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
SPITZ_DROME	spi	genetic	21439629
EGFR_DROME	Egfr	genetic	21439629

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RHDF1_DROME

Related Literatures of Post-Translational Modification