FUR11_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FUR11_DROME
• UniProt AC: P26016
• Protein Name: Furin-like protease 1, isoforms 1/1-X/2
• Gene Name: Fur1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1269
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein .
• Protein Description: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif..
• Protein Sequence: MKNDVVRWSRQPTSNTTNSSSSSRSDSNSTHKHRSKSNKLNARQLGSNAARSCQQRSSVATTLEDEQQTIIECDIGNFNFDCNLFKTSFLTQHKQKRSGKSSSKSKSNRSRPLAKTKAVFLLALQFSAVVFLCNINVGFVAGSVATAASSAGGSSPAAPSSAPSSPPTVAVPPPPPPSSALKVDPNGQSPVLPPYVLDYETGGKAKLTPNNGKFGQSGSSGSNNNHIVGHYTHTWAVHIPNGDNGMADAVAKDHGFVNLGKIFDDHYHFAHHKVSKRSLSPATHHQTRLDDDDRVHWAKQQRAKSRSKRDFIRMRPSRTSSRAMSMVDAMSFNDSKWPQMWYLNRGGGLDMNVIPAWKMGITGKGVVVTILDDGLESDHPDIQDNYDPKASYDVNSHDDDPMPHYDMTDSNRHGTRCAGEVAATANNSFCAVGIAYGASVGGVRMLDGDVTDAVEARSLSLNPQHIDIYSASWGPDDDGKTVDGPGELASRAFIEGTTKGRGGKGSIFIWASGNGGREQDNCNCDGYTNSIWTLSISSATEEGHVPWYSEKCSSTLATTYSSGGQGEKQVVTTDLHHSCTVSHTGTSASAPLAAGIAALVLQSNQNLTWRDLQHIVVRTAKPANLKDPSWSRNGVGRRVSHSFGYGLMDAAEMVRVARNWKAVPEQQRCEINAPHVDKVIPPRTHITLQLTVNHCRSVNYLEHVQAKITLTSQRRGDIQLFLRSPANTSVTLLTPRIHDNSRSGFNQWPFMSVHTWGESPQGNWQLEIHNEGRYMGHALLREWSLIFYGTTQSIGPNDPISVPKPSGSEATTPNSSSTTSNLHQAYSPQYPRIPPNNFGSSPSGGSKLPLGKVPPPNKSSYVTNNPLLNSAPPKQGYQQISATYGVILGKANGKSNNNSKEKTNNKGNKSNNGNKGKSGGSSGNRKEQTTQSTIIQTSTSKNKYYRISQQQQQKNNKQDRNGVQTQRPKANSGEKSYDEKSRKVVGEITTNSGNGSIKAAKQVKESTTTSSNSRIPKLFERYEKIQAIFPELEPYENSSPKGKPKQAKQGKQFEVDLFKPTNGGNSRQGNTKKSPSVPPPSQTMATLSILPILPAGGSSFLPDQKILKKQQLLMAAAGVMAPAQVEVEMEEVHATPDYEARKDQRKEVNGPNAQITQWDMIFYGTETPAQPDDVANPSQSNQFNLYGNDMAHNDVEYDSTGQWRNMQQVGEVGMTRDHSNTAACLKWSDRKCLGLSLLFFMIMQVFFLNFKHANDNNNKNKNNIIKCIR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	N-linked_Glycosylation	WSRQPTSNTTNSSSS ECCCCCCCCCCCCCC	54.09	-
18	N-linked_Glycosylation	QPTSNTTNSSSSSRS CCCCCCCCCCCCCCC	37.54	-
28	N-linked_Glycosylation	SSSRSDSNSTHKHRS CCCCCCCCCCCCHHH	56.79	-
108	N-linked_Glycosylation	SSSKSKSNRSRPLAK CCCCCCCCCCCHHHH	50.08	-
333	N-linked_Glycosylation	MVDAMSFNDSKWPQM HHHHHCCCCCCCCCE	45.39	-
426	N-linked_Glycosylation	GEVAATANNSFCAVG HHHHHCCCCCCEEEE	40.08	-
606	N-linked_Glycosylation	LVLQSNQNLTWRDLQ HHHHCCCCCCHHHHH	43.62	-
727	N-linked_Glycosylation	LFLRSPANTSVTLLT EEEECCCCCEEEEEC	35.95	-
814	N-linked_Glycosylation	GSEATTPNSSSTTSN CCCCCCCCCCCCCCC	53.05	-
857	N-linked_Glycosylation	LGKVPPPNKSSYVTN CCCCCCCCCCCCCCC	63.72	-
897	N-linked_Glycosylation	KANGKSNNNSKEKTN ECCCCCCCCCCCCCC	62.33	-
908	N-linked_Glycosylation	EKTNNKGNKSNNGNK CCCCCCCCCCCCCCC	46.31	-
994	N-linked_Glycosylation	EITTNSGNGSIKAAK EEECCCCCCCEEEEE	40.64	-
1013	Phosphorylation	STTTSSNSRIPKLFE CCCCCCCCHHHHHHH	33.27	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FUR11_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FUR11_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FUR11_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of FUR11_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.