DOA_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DOA_DROME
• UniProt AC: P49762
• Protein Name: Serine/threonine-protein kinase Doa
• Gene Name: Doa
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 832
• Subcellular Localization: Isoform C: Cytoplasm, cytosol.; Isoform A: Nucleus. Mainly nuclear with only low levels present in the cytoplasm.
• Protein Description: Negative regulator of the copia retrotransposon element of the white (w) gene. In the eye, it is required for normal pigmentation, photoreceptor cell development and for organization of interommatidial bristles. Also essential for embryonic segmentation and differentiation of the nervous system. Functions in the control of alternative splicing by phosphorylating the arginine/serine-rich splicing factors, SR proteins..
• Protein Sequence: MVAANLEVPTSSSSSAATKRQKDVDNKLEKCLNDMLKLKTSSNNNSTSNSNNNAIMSHSLTGEHKDPKTALEGPTSSSSSSSSKYIGESQIPVPVQLYDPQKPLLQQQQQQQRICYPIGKSNSTSQLPMGGYQRLLQHQQQQHHQQQQQQHQEQQQYPQHKRPFLNWNSFACSAMNGASDPFMQQQHMPAHQQQQHLPHKLQQSYSSSHVPKQAPKSGLAMFLQKNTNKENKFGQPMQQQPPGMMPQMYGYQAPQQQSKIGYPRTGAPLTHSASFSSAQRPTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPERKPLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASSSSNKQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSALGLHFIETAKPVIQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARNHTLYSKTKTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFFDRLPPHHRVGEVSNKQPLSSGSSSRERSHSLSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14 (in isoform 3)	Phosphorylation	-	26.41	19429919
15 (in isoform 3)	Phosphorylation	-	24.70	19429919
18 (in isoform 3)	Phosphorylation	-	26.86	19429919
27 (in isoform 3)	Phosphorylation	-	54.26	19429919
31 (in isoform 3)	Phosphorylation	-	2.91	19429919
39 (in isoform 3)	Phosphorylation	-	44.78	19429919
44 (in isoform 3)	Phosphorylation	-	45.86	22668510
46 (in isoform 3)	Phosphorylation	-	35.02	22668510
68 (in isoform 3)	Phosphorylation	-	57.47	19429919
72 (in isoform 3)	Phosphorylation	-	61.74	19429919
76 (in isoform 3)	Phosphorylation	-	31.21	23607784
83 (in isoform 2)	Phosphorylation	-	31.27	19429919
84 (in isoform 2)	Phosphorylation	-	42.72	19429919
87 (in isoform 2)	Phosphorylation	-	25.97	19429919
89 (in isoform 3)	Phosphorylation	-	28.35	19429919
93 (in isoform 3)	Phosphorylation	-	8.51	19429919
96 (in isoform 2)	Phosphorylation	-	28.38	19429919
97 (in isoform 3)	Phosphorylation	-	5.50	19429919
100 (in isoform 2)	Phosphorylation	-	30.45	19429919
108 (in isoform 2)	Phosphorylation	-	30.04	19429919
109 (in isoform 3)	Phosphorylation	-	38.42	19429919
110 (in isoform 3)	Phosphorylation	-	36.72	19429919
112 (in isoform 3)	Phosphorylation	-	32.16	19429919
113 (in isoform 2)	Phosphorylation	-	19.33	22668510
113 (in isoform 3)	Phosphorylation	-	19.33	19429919
114 (in isoform 3)	Phosphorylation	-	1.99	19429919
115 (in isoform 2)	Phosphorylation	-	3.44	22668510
128 (in isoform 3)	Phosphorylation	-	16.25	19429919
137 (in isoform 2)	Phosphorylation	-	36.61	19429919
141 (in isoform 2)	Phosphorylation	-	37.70	19429919
145 (in isoform 2)	Phosphorylation	-	40.42	23607784
158 (in isoform 2)	Phosphorylation	-	26.01	19429919
162 (in isoform 2)	Phosphorylation	-	25.69	19429919
166 (in isoform 2)	Phosphorylation	-	35.94	19429919
178 (in isoform 2)	Phosphorylation	-	13.03	19429919
179 (in isoform 2)	Phosphorylation	-	47.41	19429919
181 (in isoform 2)	Phosphorylation	-	24.90	19429919
182 (in isoform 2)	Phosphorylation	-	9.18	19429919
183 (in isoform 2)	Phosphorylation	-	4.23	19429919
197 (in isoform 2)	Phosphorylation	-	4.06	19429919
819	Phosphorylation	SNKQPLSSGSSSRER CCCCCCCCCCCHHHH	50.83	28490779
821	Phosphorylation	KQPLSSGSSSRERSH CCCCCCCCCHHHHHH	27.39	28490779
822	Phosphorylation	QPLSSGSSSRERSHS CCCCCCCCHHHHHHC	36.62	28490779
823	Phosphorylation	PLSSGSSSRERSHSL CCCCCCCHHHHHHCC	39.60	28490779

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DOA_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DOA_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DOA_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBPE_DROME	Ubp64E	physical	14605208
NUBP2_DROME	CG4858	physical	15575970
DOA_DROME	Doa	physical	15575970
CAS_DROME	cas	physical	15575970
CLCN2_DROME	ClC-a	physical	15575970
Y9776_DROME	CG9776	physical	15575970
PP4C_DROME	Pp4-19C	physical	15575970
PP12_DROME	Pp1-87B	physical	15575970
RAD51_DROME	spn-A	physical	15575970
DIMM_DROME	dimm	physical	15575970
TRA2_DROME	tra2	physical	15575970
TRSF_DROME	tra	genetic	18660538
BAM_DROME	bam	genetic	23376537
EF1G_DROME	Ef1gamma	physical	19841092

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.