PLXB_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLXB_DROME
• UniProt AC: Q9V4A7
• Protein Name: Plexin-B
• Gene Name: PlexB {ECO:0000312|FlyBase:FBgn0025740}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2051
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Involved in peripheral and central nervous system axon guidance. Acts as a receptor for Sema-2a and seems to transduce signal by suppressing Rac activity and enhancing Rho activity..
• Protein Sequence: MLRKELYCANIIHVLHVLCIIIILGSQHYCVNCIEELPAQALSPLNDIVAQFNLPSIPVQSTASSYGNRSIGNNIESVRDSQSKNYFTHMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCHAGGCPEDIETSLVNNFNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVPLAANDENASTYAFVGPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRLDDLNYAEFSIQQSIINIDVKYRDHFLVDYIYGFNSSEYAYFIIVQKKSHLADEAGYVTRLARICITDPNYDSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESKSAMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTINDGRCPIVGSLGNIYNFCSVGLKISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSGQSPGEYEEIVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCTVRSTCQRDTSASRWLSLGSGQQCIEFESIIPEKIPISELSHLHLIIRTLPEPFNAKYRCVFGNSTPIDAEILENGLGCATPPLDERPLIPTNTDHILVPLSVRSSETNKDFVSRNFAFFDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVPIEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTHEYQAKVVVTWNFQHYVDTAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWCSNSCVYNETCIADKNSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGIREEDVRGKIFIGSVPCELENYQISVKIECRTGASLYEMSAPIKVANDAGFTESSVQFHFKNVLLTGLYPTIGPRSGGTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTLECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIYLNSIQKPELEVFYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSFQTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNVQLVRNLNKYFHDIRSTIVYLADPKYLPFPNDGVKLYKGDSLVIEGELLNLAADEYDVNVTIGTSQCNITSLALNQLLCIPPEQQPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYDLNKPYVFSHALLVGILTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQAFAELQTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSPQTNYDAAMVQFEQLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASKHPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSLSEERLLHEQVTHSVVILHILQDDLDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNEVDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAVMSLIARQNDNYHIPYSKNQNSAPYHNFYFINNSQSHIIINNDIESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSPAFQSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTVNEELPPAVKWLFDLLDEAARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEHRLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKELYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDGDCTSNC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
68	N-linked_Glycosylation	STASSYGNRSIGNNI CCCHHHCCCCCCCCC	26.71	-
198	N-linked_Glycosylation	PLAANDENASTYAFV EEECCCCCCCCEEEE	41.89	-
276	N-linked_Glycosylation	VDYIYGFNSSEYAYF EEEEEECCCCCEEEE	40.02	-
400	N-linked_Glycosylation	ENIHLCFNGTTKDRN CCEEEEEECCCCCCC	46.00	-
455	N-linked_Glycosylation	HALFHFDNVSVTSVT EEEEEECCEEEEEEE	27.33	-
514	Phosphorylation	ILPNTMMSPKKDFLY CCCCCCCCCCCCEEH	23.81	22817900
541	N-linked_Glycosylation	EHCSVYTNCSACLES EECEEECCHHHHHHC	10.48	-
863	N-linked_Glycosylation	CSNSCVYNETCIADK ECCCCEECCEEEECC	20.08	-
1053	N-linked_Glycosylation	HLVIDGANRTLECQI EEEEECCCCEEEEEE	42.89	-
1092	N-linked_Glycosylation	RQPCSIFNYTQDPRI CCCCCCCCCCCCCCE	36.95	-
1140	N-linked_Glycosylation	FYDNERVNKTSCVVI EECCCCCCCCEEEEE	48.38	-
1181	N-linked_Glycosylation	DTELHLQNSSFQTET CCEEECCCCCCCCCH	46.08	-
1307	N-linked_Glycosylation	AADEYDVNVTIGTSQ CCCCCEEEEEECCCC	23.47	-
1316	N-linked_Glycosylation	TIGTSQCNITSLALN EECCCCCCHHHHHHH	32.70	-
1478	Phosphorylation	SDHPILNSPKFREGS CCCCCCCCCCCCCCC	26.48	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLXB_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLXB_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLXB_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHO1_DROME	Rho1	genetic	11604137
SEM2A_DROME	Sema-2a	genetic	17109838
RAC1_DROME	Rac1	genetic	11604137
SEM2A_DROME	Sema-2a	physical	16672342
RAC1_DROME	Rac1	physical	11267870
ITBX_DROME	mys	physical	26853303

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.